Endovascular Repair of Thoracic Aortic Aneurysm in Dogs: Evaluation of a Nitinol-Polyester Self-Expanding Stent-Graft

Formichi, Maxime; Marois, Yves; Roby, Patrice; Маринов, Г.; Stroman, Patrick W.; King, Martin W.; Douville, Yvan; Guidoin, Robert

doi:10.1177/152660280000700108

Cited by 23 publications

(21 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the thoracic aorta was completely clamped in the surgical procedure of other aneurismal models. [14][15][16] That may increase the risk of distal infarction. We clamped the anterolateral wall of the thoracic aorta.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the aneurismal model suitable for the research of branched stent graft should be adjacent to or involve the left subclavian artery. Recently, all the animal models of thoracic aortic aneurysm were situated in the medial segment of the descending thoracic aorta, [14][15][16] while the average distance between our aneurismal model and the left subclavian artery was 8.29 ± 0.91 mm. Thus, the aneurismal model is suitable for the research of new branched stent grafts.…”

Section: Discussionmentioning

confidence: 99%

“…Formichi et al created animal models of thoracic aortic aneurysms in mongrel dogs using polyester patches. 14) Ikonomidis et al used calcium chloride to create thoracic aortic aneurysms in mice. 15) Kajimoto et al used jugular vein patches to create thoracic aortic aneurysms in beagles.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the prosthetic polyester patch used by Formichi et al could not imitate the structure of natural aortic aneurysm. 14) We created the aneurismal model by using autologous pericardium patch. Light photomicrography showed that the aneurismal wall was much thinner than the thoracic aorta; the pericardium patch was covered with mechanocyte and collagenous fiber; the inner surface of the aneurismal wall was covered with endotheliocyte.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A Canine Model of Proximal Descending Thoracic Aortic Aneurysm Created with an Autologous Pericardial Patch

et al. 2013

ATCS

View full text Add to dashboard Cite

Objectives: To establish an animal model of proximal descending thoracic aortic aneurysm for the study of branched stent grafts. Materials and Methods: Eleven mongrel dogs underwent the surgical procedure during which an autologous pericardial patch was sewn onto a longitudinal incision in the anterolateral wall of the thoracic aorta near the left subclavian artery to create an artificial thoracic aortic aneurysm. Results: All eleven animals survived the surgical procedure. One animal died from rupture at the surgical site during the first week after surgery. The distance between the artificial aneurysm and the left subclavian artery was 8.29 ± 0.91 mm. The average diameter of the artificial aneurysms did not significantly change over the 4-month follow-up period. Conclusion: A canine model for proximal descending thoracic aortic aneurysm can be achieved using a safe and convenient method. The model can be used in the study of new branched stent graft applied to the aortic arch.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Canine Model of Proximal Descending Thoracic Aortic Aneurysm Created with an Autologous Pericardial Patch

et al. 2013

ATCS

View full text Add to dashboard Cite

show abstract

“…As analytical modeling and computational fluid dynamics (CFD) of aneurysmal aorta fitted with an endovascular graft is still in its infancy [44], it is of particular importance to understand the long-term behavior of an aneurysmal sac in terms of biomechanics. The endovascular graft must behave in a predictable way [45]. There have been several endovascular devices with early failure performances.…”

Section: Discussionmentioning

confidence: 99%

MRI Virtual Biopsies: Analysis of an Explanted Endovascular Device and Perspectives for the Future

Guidoin¹,

Zhang²,

Douville³

et al. 2006

Artificial Cells, Blood Substitutes, and Biotechnology

View full text Add to dashboard Cite

Information that can be obtained by magnetic resonance imaging (MRI) of explanted endovascular devices must be validated as this method is non-destructive. Histology of such a device together with its encroached tissues can be elegantly performed after polymethymethacrylate (PMMA) embedding, but this approach requires destruction of the specimen. The issue is therefore to 241 determine if the MRI is sufficient to fully validate an explanted device based upon the characterization of an explanted specimen.An AneuRx device deployed percutaneously 25 months earlier in a 75-yearold patient was removed en bloc at autopsy together with the surrounding aneurysmal sac and segments of the upstream and downstream arteries. Macroscopic pictures were taken and a slice of the cross-section was processed for histology after polymethylmethacrylate (PMMA) embedding. For the magnetic resonance imaging investigation, the device was inserted in a Biospec 4.7 T MRI system with a 20 mm diameter birdcage resonator used for both emission and reception. A Spin-Echo (SE) was used to acquire both T1 proton density (PD) and T2 weighted images. A gradient-echo (GE) sampling of a free induction decay (GESFID) was used to generate multiple GE images using a single excitation pulse so that four images at different TE were obtained in the same acquisition.The selected explanted device was outstandingly well-healed compared to most devices harvested from humans. No inflammatory process was observed in contact or at distance of the materials. In MRI T1 images display no specific contrast and were homogeneous in the different tissues. The contrast was improved on proton density weighed images. On the T2 weighed images, the different areas were well indentified. The diffusion images displayed in the surrounding B region had the greatest diffusion coefficient and the greatest anisotropy.The MRI analysis of the explanted AneuRx device illustrates the possibilities of this technique to characterize the interaction of the endovascular graft with the surrounding tissues. MRI is a breakthrough to investigate explanted medical devices but it also can be advantageously used in vivo to obtain virtual biopsies, because real biopsies to determine the 3 Bs (biocompatibility, biofunctionality and bioresilience) cannot be carried out as they could obviously initiate infection and degradation of the foreign materials.

show abstract

Biodegradable membrane‐covered stent from chitosan‐based polymers

Thierry

Merhi

Silver³

et al. 2005

J Biomedical Materials Res

View full text Add to dashboard Cite

Membrane-covered devices could help treat disease of the vasculature such as aneurysm, rupture, and fistulas. They are also investigated to reduce embolic complication associated with revascularization of saphenous vein graft. The aim of this study is to design a clinically applicable biodegradable membrane-covered stent based on the natural polysaccharide chitosan, which has been developed. The mechanical properties of the membrane is optimized through blending with polyethylene oxide (70:30% Wt CH:PEO). The membrane was able to sustain the mechanical deformation of the supporting self-expandable metallic stents during its deployment. The membrane was demonstrated to resist physiological transmural pressure (burst pressure resistance >500 mm Hg) and presented a high-water permeation resistance (1 mL/cm(2) min(-1) at 120 mmHg). The CH-PEO membrane showed a good hemocompatibility in an ex vivo assay. Heparin and hyaluronan surface complexation with the membrane further reduced platelet adhesion by 50.1 and 63% (p = 0.05). The ability of the membrane-covered devices to be used as a drug reservoir was investigated using the nitric oxide donor sodium nitroprusside (SNP). SNP-loaded membranes displayed significantly reduced platelet adhesion.

show abstract

Endovascular Repair of Thoracic Aortic Aneurysm in Dogs: Evaluation of a Nitinol-Polyester Self-Expanding Stent-Graft

Abstract: This short-term in vivo study of a nitinol-polyester self-expanding endograft demonstrated the effective exclusion of thoracic aneurysms with a satisfactory healing response and no excessive tissue or inflammatory reactions.

Cited by 23 publications

References 31 publications

A Canine Model of Proximal Descending Thoracic Aortic Aneurysm Created with an Autologous Pericardial Patch

A Canine Model of Proximal Descending Thoracic Aortic Aneurysm Created with an Autologous Pericardial Patch

MRI Virtual Biopsies: Analysis of an Explanted Endovascular Device and Perspectives for the Future

Biodegradable membrane‐covered stent from chitosan‐based polymers

Contact Info

Product

Resources

About