Endovascular Creation of an in Vivo Bifurcation Aneurysm Model in Rabbits

Cloft, Harry J.; Altes, T. A.; Marx, William F.; Raible, R J; Hudson, Sarah B.; Helm, Gregory A.; Mandell, James W.; Jensen, Mary E.; Dion, Jacques E.; Kallmes, David F.

doi:10.1148/radiology.213.1.r99oc15223

Cited by 88 publications

(66 citation statements)

References 12 publications

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“…Unfortunately, most existing animal models for cerebral aneurysms are inappropriate for this purpose because they are not "grown" but rather surgically created. 9,10 An exception is the induction of cerebral aneurysms in the circle of Willis in rodents by increased flow and hypertension. 11 These aneurysms are morphologically similar to human saccular cerebral aneurysms.…”

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confidence: 99%

Complex Hemodynamics at the Apex of an Arterial Bifurcation Induces Vascular Remodeling Resembling Cerebral Aneurysm Initiation

Meng

Wang

Hoi

et al. 2007

Stroke

520

476

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Background and Purpose-Arterial bifurcation apices are common sites for cerebral aneurysms, raising the possibility that the unique hemodynamic conditions associated with flow dividers predispose the apical vessel wall to aneurysm formation. This study sought to identify the specific hemodynamic insults that lead to maladaptive vascular remodeling associated with aneurysm development and to identify early remodeling events at the tissue and cellular levels. Methods-We surgically created new branch points in the carotid vasculature of 6 female adult dogs. In vivo angiographic imaging and computational fluid dynamics simulations revealed the detailed hemodynamic microenvironment for each bifurcation, which were then spatially correlated with histologic features showing specific tissue responses. Results-We observed 2 distinct patterns of vessel wall remodeling: (1) hyperplasia that formed an intimal pad at the bifurcation apex and (2) destructive remodeling in the adjacent region of flow acceleration that resembled the initiation of an intracranial aneurysm, characterized by disruption of the internal elastic lamina, loss of medial smooth muscle cells, reduced proliferation of smooth muscle cells, and loss of fibronectin. Conclusions-Strong localization of aneurysm-type remodeling to the region of accelerating flow suggests that a combination of high wall shear stress and a high gradient in wall shear stress represents a "dangerous" hemodynamic condition that predisposes the apical vessel wall to aneurysm formation.

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mentioning

confidence: 99%

Complex Hemodynamics at the Apex of an Arterial Bifurcation Induces Vascular Remodeling Resembling Cerebral Aneurysm Initiation

Meng

Wang

Hoi

et al. 2007

Stroke

520

476

View full text Add to dashboard Cite

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“…8,[16][17][18][19] (For a review, see Massoud et al 1994. 20 ) The elastase-induced aneurysm model, most frequently used in rabbits, 21,22 has been modified in various ways. 23,24 Our aim was to review in the literature the main features of these models and their strengths and weaknesses in an effort to identify those that could serve as the most appropriate final assessor of new aneurysm devices immediately before clinical use.…”

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confidence: 99%

In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Bouzeghrane

Naggara

Kallmes³

et al. 2009

AJNR Am J Neuroradiol

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SUMMARY: Animal models are necessary to develop and test innovations in aneurysm therapy before clinical introduction. This review aims at identifying the most likely candidates for standardizing preclinical testing of aneurysm devices. We systematically searched electronic databases for publications on animal aneurysm models from 1961-2008 to assess the methodologic quality of the studies and collect data on the patency and angiographic and pathologic outcomes of treatments. There has been a steady increase in the annual number of publications with time. Species that were most frequently used were dogs, rabbits, and rodents, followed by swine. Most publications are single-laboratory studies with variables and poorly validated outcome measures, a small number of subjects, and limited standardization of techniques. The most appropriate models to test for recurrences after endovascular occlusion were the surgical bifurcation model in dogs, and the elastase-induced aneurysm model in rabbits. A standardized multicenter study is needed to improve the preclinical evaluation of endovascular devices in aneurysm therapy.

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“…Elastase-induced aneurysms have previously been created from the LCCA, 18 in which the aneurysms were created by using transfemoral endovascular means with distal LCCA occlusion by using detachable balloons or coils; elastase injury was achieved from an endovascular approach that was time-consuming and associated with substantial morbidity. The current study offers a practical, simple direct surgical exposure method, which is similar to that widely applied for RCCA aneurysm creation.…”

Section: Discussionmentioning

confidence: 99%

Creation of Bifurcation-Type Elastase-Induced Aneurysms in Rabbits

Ding¹,

Kadirvel²,

Dai³

et al. 2011

AJNR Am J Neuroradiol

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SUMMARY:Elastase incubation was performed in the LCCA in 13 New Zealand white rabbits. Three weeks after incubation, DSA demonstrated that 10 (10/13, 77%) bifurcation-type aneurysms at the origin of the LCCA were present; mean aneurysm neck, width, and height values were 3.7 Ϯ 1.1, 3.8 Ϯ 0.9, and 8.7 Ϯ 2.3 mm, respectively. The LCCA can be used to create bifurcation aneurysms in rabbits. ABBREVIATIONS:DSA ϭ digital subtraction angiography; IADSA ϭ intra-arterial digital subtraction angiography; IVDSA ϭ intravenous digital subtraction angiog-

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Endovascular Creation of an in Vivo Bifurcation Aneurysm Model in Rabbits

Abstract: This aneurysm model re-created the hemodynamic forces and size of human cerebral bifurcation aneurysms and maintained the integrity of the endothelium. The creation of the aneurysms was rapid, reliable, and reproducible.

Cited by 88 publications

References 12 publications

Complex Hemodynamics at the Apex of an Arterial Bifurcation Induces Vascular Remodeling Resembling Cerebral Aneurysm Initiation

Complex Hemodynamics at the Apex of an Arterial Bifurcation Induces Vascular Remodeling Resembling Cerebral Aneurysm Initiation

In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Creation of Bifurcation-Type Elastase-Induced Aneurysms in Rabbits

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