Endotypes of chronic rhinosinusitis based on inflammatory and remodeling factors

Wang, Xiangdong; Sima, Yutong; Zhao, Yan; Zhang, Nan; Zheng, Ming; Du, Kun; Wang, Min; Wang, Yue; Hao, Yun; Liu, Ying; Liu, Manjiao; Piao, Yingshi; Liu, Chengyao; Tomassen, Peter; Zhang, Luo; Bachert, Claus

doi:10.1016/j.jaci.2022.10.010

Cited by 32 publications

(20 citation statements)

References 69 publications

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“…Our studies have classified three major endotypes in CRS as T1 (IFN-γ), T2 (IL-5, ECP, and CLC), and T3 (IL-17A), with a untypeable (Tun) endotype that lacks elevated T1, T2, and T3 [5,6]. Wang et al [7 ▪ ] identified five clusters based on 16 biomarkers of northern Chinese population: two clusters exhibit low IL-19 and IL-27 levels and are non-T2, while the other three show different T2 (IL-5, ECP, eotaxin, and IgE) levels, some with T3 and neutrophilic (IL-17, G-CSF, IL-8, and MPO) inflammation. Transcriptomic approaches have helped characterize endotypes at a detailed molecular level, revealing globally overlapping inflammatory molecules in both ECRS and NECRS through comparative studies between Asian and Western populations.…”

Section: Introductionmentioning

confidence: 95%

“…The T2 endotype has been associated with more severe clinical manifestations and poor outcomes including polyposis, asthma, AERD, anosmia, presence of allergic mucin, olfactory dysfunction, and disease recurrence [4,7 ▪ ,71]. IL-13 driven epithelial remodeling is correlated with sinus opacification observed on radiographic score [72], together with IL-5, correlated with olfaction [73].…”

Section: Endotypes and Their Association With Clinical Implicationsmentioning

confidence: 99%

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Endotypic heterogeneity and pathogenesis in chronic rhinosinusitis

Bai,

Tan,

Kato

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review This review aims to provide updates in realms of endotypic heterogeneity, pathogenesis at the molecular level, potential of biomarkers, and cutting-edge scope of biologics in CRS. Recent findings High-dimensional analyses, such as transcriptomes, and machine learning, have significantly enhanced CRS endotyping, uncovering diverse pathogenetic mechanisms contributing to its heterogeneity. The dynamic process of epithelial remodeling in CRS pathogenesis has gained more clarity and support as exemplified by IL-13 and oncostatin M (OSM) that are shown intricately linked to epithelial barrier dysfunction. Moreover, anti-dsDNA autoantibody, BAFF, periostin, and cystatin SN show promise as potentials biomarkers, offering diagnostic and prognostic value for CRS. Summary The identification of inflammatory molecules involved in endotype specific signaling pathways provides insights into the underlying mechanisms and verifiable biomarkers for diagnosis and prediction of disease severity. More comprehensive clinical studies should be conducted to facilitate biologics from bench to bedside in treating CRS.

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Section: Introductionmentioning

confidence: 95%

Section: Endotypes and Their Association With Clinical Implicationsmentioning

confidence: 99%

Endotypic heterogeneity and pathogenesis in chronic rhinosinusitis

Bai,

Tan,

Kato

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Research on the mechanism and treatment of non-type 2 immune response lags far behind that of type 2 immune responses [162]. Currently, no biologics targeting nontype 2 factors have been used in CRS [163][164][165]. The development of biologic therapies for non-type 2 inflammation seems to be more difficult than for type 2 inflammation [61].…”

Section: Biologic Therapiesmentioning

confidence: 99%

A Decade of Pathogenesis Advances in Non-Type 2 Inflammatory Endotypes in Chronic Rhinosinusitis: 2012–2022

Cui,

Zhu,

Zhao

et al. 2023

Int Arch Allergy Immunol

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Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by localized inflammation of the upper airways. CRS includes two main phenotypes, namely, CRS with nasal polyps and CRS without nasal polyps. The phenotype-based classification method cannot reflect the pathological mechanism. The endotype-based classification method has been paid more and more attention by researchers. It is mainly divided into type 2 and non-type 2 endotypes. The mechanism driving the pathogenesis of non-type 2 inflammation is currently unknown. In this review, the PubMed and Web of Science databases were searched to conduct a critical analysis of representative literature works on the pathogenesis of non-type 2 inflammation in CRS published in the past decade. This review summarizes the latest evidence that may lead to the pathogenesis of non-type 2 inflammation. It is the main method that analyzing the pathogenesis from the perspective of immunology. Genomics and proteomics technique provide new approaches to the study of the pathogenesis. Due to differences in race, environment, geography, and living habits, there are differences in the occurrence of non-type 2 inflammation, which increase the difficulty of understanding the pathogenesis of non-type 2 inflammation in CRS. Studies have confirmed that non-type 2 endotype is more common in Asian patients. The emergence of overlap and unclassified endotypes has promoted the study of heterogeneity in CRS. In addition, as the source of inflammatory cells and the initiation site of the inflammatory response, microvessels and microlymphatic vessels in the nasal mucosal subepithelial tissue participate in the inflammatory response and tissue remodeling. It is uncertain whether CRS patients affect the risk of infection with SARS-CoV-2. In addition, the pathophysiological mechanism of non-type 2 CRS combined with COVID-19 remains to be further studied, and it is worth considering how to select the befitting biologics for CRS patients with non-type 2 inflammation.

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“…In addition, he constructed a decision tree model through the combination of nasal secretion biomarkers and clinical characteristics of CRS patients to accurately define type 2 CRSwNP patients in a non-invasive way to give more rational treatment to patients in the clinic [30] . Prof. Bachert Claus' group has focused on various directions, including endotypes clustering of CRS patients based on different molecules, surgery, biological therapies, pathophysiological mechanisms, and so on [28][29][30][31][32][33][34][35] . plasminogen activator, and oral CRTH2 antagonist [36][37][38] .…”

Section: Leading Experts and Related Directionsmentioning

confidence: 99%

Visual and bibliometric analysis of Chronic Rhinosinusitis and Nasal Polyps

Jiao

Liu

Yao

et al. 2023

Preprint

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Background: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by persistent sinonasal inflammation and sinus microbiome dysbiosis. Nasal polyps (NPs) is one of the main manifestations which cause diverse clinical symptoms of CRS. We conducted a bibliometric and visual analysis of CRS and NPs articles published between 2003 and 2022 to provide researchers with the current state of research and potential directions. Method: We used a systematic search strategy to search relevant articles in the databases of the Web of Science from 2003 to 2022. VOSviewers, Bibliometrix R package, and CiteSpace were used to perform the bibliometric analysis. Results: 3,907 publications, including 3,266 “articles” and 641 “reviews” were retrieved. The USA made the highest contributions to global research, followed by China; furthermore, Northwestern University, Capital Medical University, and Sun Yat-Sen University had the highest number of publications. A total of 12,894 authors participated in this research, with the most published author being Bachert C., followed by Schleimer Robert P. and Schlosser Rodney J.. And the authors with the most co-citations were Bachert C., Fokkens W.J., and Gevaert P. 428 journals had published the articles of this research. Moreover, the journal with the most publications was the International Forum Of Allergy & Rhinology and the Journal Of Allergy And Clinical Immunology received the most citations. “Covid-19”, “biologic”, and “type 2 inflammation” were the top current research hotspots. Conclusion: The United States and Northwestern University were the leading country and institution in researching CRS and NPs. And Bachert C. is the most influential expert. The International Forum Of Allergy & Rhinology published the most articles, and the Journal Of Allergy And Clinical Immunology got the highest number of citations. Moreover, “Covid-19”, “biologic”, and “type 2 inflammation” were the trending topics.

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Endotypes of chronic rhinosinusitis based on inflammatory and remodeling factors

Cited by 32 publications

References 69 publications

Endotypic heterogeneity and pathogenesis in chronic rhinosinusitis

Endotypic heterogeneity and pathogenesis in chronic rhinosinusitis

A Decade of Pathogenesis Advances in Non-Type 2 Inflammatory Endotypes in Chronic Rhinosinusitis: 2012–2022

Visual and bibliometric analysis of Chronic Rhinosinusitis and Nasal Polyps

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