Endotoxin induced production of interleukin-6 is enhanced by vitamin E deficiency and reduced by black tea extract

Abstract

Studies were performed to investigate the effect of a polyphenol rich extract from black tea and vitamin E on bacterial lipopolysaccharide (endotoxin) induced IL-6 production, alterations in liver glutathione and antioxidant acute phase protein (caeruloplasmin) concentration, in rats fed on a synthetic diet for 21 days. In the vitamin E sufficient group a significantly lower IL-6 concentration than in vitamin E deficient animals was observed. Addition of tea extract to the diet produced a similar reduction in IL-6, but no synergism occurred in the presence of both vitamin E and tea extract. However, a significantly lower caeruloplasmin and a significantly higher liver glutathione concentration was observed in rats fed both substances. It is suggested that consideration of dietary components which alter antioxidant/oxidant status may contribute towards treatment of inflammatory/autoimmune diseases.

Effects of Vitamin C or E on the Pro-inflammatory Cytokines, Heat Shock Protein 70 and Antioxidant Status in Broiler Chicks under Summer Conditions

“…In particular, IL-1β and IL-18, which belong to the IL-1 family of pro-inflammatory cytokines, are actively involved in an inflammatory response and the secretion of antibody under hyperthermia in animal models (Lin et al, 1994; Helwig and Leon, 2011). Similar to our observation, it has been reported that dietary supplementation of antioxidant vitamins decreased the expression of pro-inflammatory cytokines such as IL-6, IL-2 and TNF-α in rodents (Amarakoon et al, 1995; Yun et al, 2012). Yun et al (2012) also reported that in heat stressed rats dietary vitamin C supplementation produced significantly lower mRNA levels of hepatic IL-6 and TNF-α than controls.…”

Inhibition of Premature Death by Isothiocyanates through Immune Restoration in LP-BM5 Leukemia Retrovirus-Infected C57BL/6 Mice

“…It has also been reported that rats fed diets deficient in vitamin E after injections of endotoxin showed more anorexia and expressed higher IL-6 levels than animals consuming adequate amounts. 32) Lipid peroxidation was also found to be greater in the vitamin E-deficient animals in this study.…”

Toluene Diisocyanate Exposure Induces Laryngo-tracheal Eosinophilia, which can be Ameliorated by Supplementation with Antioxidant Vitamins in Guinea Pigs

“…Original magnifications: )/80. was correlated with increased production of the proinflammatory cytokine IL-6, as compared with vitamin E-replete controls (16,25). Vitamin E is capable of inhibiting the activation of a transcription factor required for the expression of many pro-inflammatory cytokine genes, such as tumor necrosis factor-a (16,25).…”

“…There have been some experimental studies on suppression of inflammation by vitamin E. Rats made deficient in vitamin E showed exaggerated inflammatory reactions (16). Experimental peritonitis was suppressed by vitamin E supplementation in rats (17).…”