Endotoxemia is modulated by quantity and quality of dietary fat in older adults

López-Moreno, Javier; García‐Carpintero, Sonia; Gómez-Delgado, Francisco; Jiménez-Lucena, Rosa; Vals-Delgado, Cristina; Alcalá‐Díaz, Juan F.; Roncero-Ramos, Irene; Rangel‐Zúñiga, Oriol A.; Yubero‐Serrano, Elena M.; Malagón, Marı́a M.; Ordovás, José M.; Pérez-Martínez, Pablo; López‐Miranda, José; Camargo, Antonio

doi:10.1016/j.exger.2017.11.006

Cited by 14 publications

(25 citation statements)

References 33 publications

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“…In an intervention study, the increase in energy intake (+70 g fat for eight weeks) was associated with an acute rise in endotoxin levels in the postprandial state, but not in the fasting state [46] (Table 2). More recently, three weeks of an intervention based on a low-fat high-carbohydrate diet enriched in n-3 PUFA has been shown to increase the postprandial levels of LPS, but decrease the fasting levels of LPS, compared with a Mediterranean diet enriched in MUFA or a SFA-rich diet, among healthy older subjects [47]. Among 75 metabolically impaired subjects, adherence to a high-fat high-saturated-fatty acid diet for 12 weeks led to an increase in the postprandial levels of LPS, but not the fasting levels [48].…”

Section: Associations Between Long-term Dietary Interventions and Cirmentioning

confidence: 99%

Metabolic Endotoxemia: A Potential Underlying Mechanism of the Relationship between Dietary Fat Intake and Risk for Cognitive Impairments in Humans?

2019

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(1) Background: Nutrition is a major lifestyle factor that can prevent the risk of cognitive impairment and dementia. Diet-induced metabolic endotoxemia has been proposed as a major root cause of inflammation and these pathways emerge as detrimental factors of healthy ageing. The aim of this paper was to update research focusing on the relationship between a fat-rich diet and endotoxemia, and to discuss the potential role of endotoxemia in cognitive performances. (2) Methods: We conducted a non-systematic literature review based on the PubMed database related to fat-rich meals, metabolic endotoxemia and cognitive disorders including dementia in humans. A total of 40 articles out of 942 in the first screening met the inclusion criteria. (3) Results: Evidence suggested that a fat-rich diet, depending on its quality, quantity and concomitant healthy food components, could influence metabolic endotoxemia. Since only heterogeneous cross-sectional studies are available, it remains unclear to what extent endotoxemia could be associated or not with cognitive disorders and dementia. (4) Conclusions: A fat-rich diet has the capability to provide significant increases in circulating endotoxins, which highlights nutritional strategies as a promising area for future research on inflammatory-associated diseases. The role of endotoxemia in cognitive disorders and dementia remains unclear and deserves further investigation.

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Section: Associations Between Long-term Dietary Interventions and Cirmentioning

confidence: 99%

Metabolic Endotoxemia: A Potential Underlying Mechanism of the Relationship between Dietary Fat Intake and Risk for Cognitive Impairments in Humans?

2019

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“…It causes a low-grade transient inflammatory state that can be studied by measuring serum concentrations of markers such as IL-6 and high-sensitive C-reactive protein (hs-CRP). These postprandial changes have been associated with development of cardiovascular disease (Borén, Matikainen, Adiels, & Taskinen, 2014) and their magnitude seems to be related to metabolic status of individuals (Badoud et al, 2015) and intake content (López et al, 2018;Teeman et al, 2016). Saturated Fatty Acids (SFA) promote inflammatory reactions, while omega 3 (n3) polyunsaturated fatty acids (PUFA) and polyphenols cause the opposite effect, so their consumption is considered beneficial for health (Derosa, Cicero, D'Angelo, Borghi, & Maffioli, 2016;Guess, Perreault, Kerege, Strauss, & Bergman, 2016).…”

Section: Introductionmentioning

confidence: 99%

Metabolic status is related to the effects of adding of sacha inchi (Plukenetia volubilis L.) oil on postprandial inflammation and lipid profile: Randomized, crossover clinical trial

2018

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Sacha inchi oil (SIO) is an attractive source of polyunsaturated acids oil. A randomized crossover clinical trial was done to evaluate SIO effects on postprandial lipids and inflammatory state caused by a high‐fat intake. Twenty metabolically healthy (MH) and 22 metabolically unhealthy (MU) subjects consumed a high‐fat breakfast alone or supplemented with SIO. The biomarkers were measured in serum upon fasting, and after 1 and 4 hrs after breakfast. Interleukin‐6 (IL‐6) expression was determined in mononuclear cells. In the MH group, SIO reversed the cholesterol increase [iAUCHFM: 0.27 mmol/L/4 h (IQR: −0.07/0.81); iAUCHFM+S: −0.18 mmol/L/4 h (IQR: −0.49/0.31) p = 0.037] and decreased interleukin‐6 concentration. In MU group, SIO attenuated lipopolysaccharides increase and interleukin‐6 expression [(FCHFM = −1.19 (IQR: −1.72/1.93) and FCHFM+S = −1.83 (IQR: −4,82/−0.01), p = 0.017]. The effects of a high‐fat meal on postprandial lipids and inflammation could be modified by the addition of SIO, but the outcomes are depending on the metabolic individual status. Practical applications The seeds of Plukenetia volubilis L., also known as Sacha inchi, Sacha peanut or Inca peanut are an attractive vegetable source of oil which includes a high content of polyunsaturated fatty acids. Furthermore, the intake of Sacha inchi oil could improve the postprandial responses of a high‐fat intake, and could be able to help to prevent cardiovascular diseases. Our results contribute to know the effects of this oil on postprandial inflammation and lipids. In addition, establishing how a person’s basal metabolic status can determinate the metabolic response to this oil can help improve its use, and our results add evidence about the role of nutrition and diet in health and disease. At this time, the cultivation of Sacha inchi is being proposed as an agro‐industrial alternative for the improvement of quality of living in Colombian rural areas.

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“…An interesting interplay does exist between the prevalent consumption of specific dietary lipids, LPS plasma levels and risk of endotoxemia. In healthy elderly subjects, the consumption of a carbohydrate-based/PUFAs-enriched diet has been shown to be associated to lower fasting LPS plasma levels, while the ingestion of diets rich either of SFAs or MUFAs resulted in higher fasting endotoxemia [98]. The hierarchy of the impact on LPS plasma levels is better clarified by considering these results at the light of a previous study in which the consumption of a Mediterranean-like diet (e.g., MUFAs-enriched) decreases the postprandial pro-inflammatory response more than the consumption of PUFA diet and much more than SFA-based diet [99].…”

Section: Dietary Lipids: Fatty Acids Alteration Of Microbiota Diversmentioning

confidence: 99%

Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases

Marrone

Coccurello

2019

Biomolecules

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The gut-brain axis is a multimodal communication system along which immune, metabolic, autonomic, endocrine and enteric nervous signals can shape host physiology and determine liability, development and progression of a vast number of human diseases. Here, we broadly discussed the current knowledge about the either beneficial or deleterious impact of dietary fatty acids on microbiota-brain communication (MBC), and the multiple mechanisms by which different types of lipids can modify gut microbial ecosystem and contribute to the pathophysiology of major neuropsychiatric diseases (NPDs), such as schizophrenia (SCZ), depression and autism spectrum disorders (ASD).

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Endotoxemia is modulated by quantity and quality of dietary fat in older adults

Cited by 14 publications

References 33 publications

Metabolic Endotoxemia: A Potential Underlying Mechanism of the Relationship between Dietary Fat Intake and Risk for Cognitive Impairments in Humans?

Metabolic Endotoxemia: A Potential Underlying Mechanism of the Relationship between Dietary Fat Intake and Risk for Cognitive Impairments in Humans?

Metabolic status is related to the effects of adding of sacha inchi (Plukenetia volubilis L.) oil on postprandial inflammation and lipid profile: Randomized, crossover clinical trial

Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases

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