Endotoxemia in Psoriasis

Belew, Patricia W.

doi:10.1001/archderm.1982.01650150004006

Cited by 11 publications

(3 citation statements)

References 4 publications

(2 reference statements)

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“…There are many papers discussing microorganisms, including bacteria and fungi, in psoriasis (18–24). Particularly, early publications have discussed Streptococcus and psoriasis.…”

Section: Discussionmentioning

confidence: 99%

“…Tonsillitis and streptococcal infections have been reported as clinical associations of psoriasis, and tonsillectomy is clinically effective (25). There are a few articles considering gram‐negative organisms such as Proteus, Klebsiella and Serratia in psoriasis (20), and endotoxemia is present in psoriasis (18). With regard to yeasts, early investigators reported high occurrences of intestinal carriage of Candida in psoriatic patients.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, it has been repeatedly observed that systemic and focal microbial infections cause or exacerbate psoriatic lesions. Removal of these microbial foci can result in clearing of the disease (18–25). In addition, peripheral blood monocytes in psoriatic patients after a tonsillar provocation test increased the production of inflammatory cytokines such as TNF‐α, IL‐1β and IL‐8, and the cases which responded to tonsillectomy showed a significant decrease in monocyte cytokine production (11, 12).…”

Section: Introductionmentioning

confidence: 99%

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Increased Microorganisms DNA Levels in Peripheral Blood Monocytes from Psoriatic Patients Using PCR with Universal Ribosomal RNA Primers

Okubo

Oki

Takeda

et al. 2002

The Journal of Dermatology

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It has long been suspected that systemic and focal infections cause or exacerbate psoriatic lesions. We previously showed that peripheral blood monocytes in psoriatic patients are activated and overproduce inflammatory cytokines. In addition, it has been reported that macrophages activated by ingesting microorganisms release tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta. Therefore we hypothesized that the monocytes in psoriatic patients may be activated by ingesting microorganisms and overproduce inflammatory cytokines. We examined the detection of microorganism DNA in monocytes from 15 patients with psoriasis vulgaris and from 12 healthy controls. DNA was extracted from monocytes, and a polymerase chain reaction (PCR) assay was performed for the detection using universal primers from conserved regions of the bacterial 16S ribosomal RNA gene or the fungal 18S rRNA gene. At the same time, we calculated the psoriasis area and severity index (PASI) scores and analyzed their correlations with the microorganisms DNA levels. The results showed that bacterial 16S DNA levels in monocytes were significantly higher in psoriatic patients than in controls. The fungal 18S DNA levels were also higher in psoriatic patients than in controls, but the differences were not significant. Although the microorganisms DNA levels in monocytes of psoriatic patients were high, there was no correlation between the bacterial DNA levels in monocytes of the psoriatics and PASI scores. Our study suggests that monocytes in psoriatic patients engulf more bacteria than there in controls, causing an activation of monocytes and triggering the formation of new lesions in the initial stages of psoriasis.

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“…There are many papers discussing microorganisms, including bacteria and fungi, in psoriasis (18–24). Particularly, early publications have discussed Streptococcus and psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%