Endotoxemia and acute-phase proteins in major abdominal surgery

Buttenschoen, Klaus; Buttenschoen, Daniela Carli; Berger, D.; Vasilescu, C; Schafheutle, S.; Goeltenboth, Bettina; Seidelmann, M.; Beger, Hans G.

doi:10.1016/s0002-9610(00)00534-1

Cited by 75 publications

(46 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These concentrations of the cytokines and acute-phase proteins after endotoxin were within the ranges reported in acute inflammatory disease (3,4,25).…”

Section: Cytokines Cortisol Saa and Crpsupporting

confidence: 83%

“…Six normal volunteers (three males, three females, ages [23][24][25][26][27][28][29][30][31][32][33][34][35] were admitted to The Rockefeller University Clinical Research Center in a random-order cross-over design twice for 8 days with a 6 week washout period between admissions. After a diet stabilization period, they received either a single iv dose of endotoxin or saline.…”

Section: Subjectsmentioning

confidence: 99%

See 1 more Smart Citation

A single intravenous dose of endotoxin rapidly alters serum lipoproteins and lipid transfer proteins in normal volunteers

Hudgins

Parker

Levine

et al. 2003

Journal of Lipid Research

119

103

View full text Add to dashboard Cite

“…These concentrations of the cytokines and acute-phase proteins after endotoxin were within the ranges reported in acute inflammatory disease (3,4,25).…”

Section: Cytokines Cortisol Saa and Crpsupporting

confidence: 83%

Section: Subjectsmentioning

confidence: 99%

A single intravenous dose of endotoxin rapidly alters serum lipoproteins and lipid transfer proteins in normal volunteers

Hudgins

Parker

Levine

et al. 2003

Journal of Lipid Research

119

103

View full text Add to dashboard Cite

“…First, the effect of the operation and the subsequent healing process might be a possible explanation for the enhanced inflammatory state during the first 6 months postoperatively. However, various studies demonstrate that the highest CRP levels occur 12-48 h after surgery (40 -42) and will remain elevated only for a period of maximum 12 d postoperatively (42). Second, a nonalcoholic steatohepatitis might be an explanation for the sustained elevation of inflammatory mediators.…”

Section: Discussionmentioning

confidence: 99%

Macrophage Inhibitory Factor, Plasminogen Activator Inhibitor-1, Other Acute Phase Proteins, and Inflammatory Mediators Normalize as a Result of Weight Loss in Morbidly Obese Subjects Treated with Gastric Restrictive Surgery

Dielen¹,

Buurman²,

Hadfoune³

et al. 2004

The Journal of Clinical Endocrinology & Metabolism

136

View full text Add to dashboard Cite

Obesity is demonstrated to be associated with an enhanced inflammatory state, which is suggested to be a cause for the development of obesity-related morbidity. It was hypothesized that a decrease in body weight in morbid obese subjects would lead to a reduction of the inflammatory state in these subjects.Weight loss was achieved by gastric restrictive surgery in 27 morbidly obese patients. Preoperative as well as 3-, 6-, 12-, and 24-month postoperative plasma concentrations of inflammatory mediators macrophage inhibitory factor, plasminogen activator inhibitor-1, lipopolysaccharide binding protein, ␣-1 acid glycoprotein, C-reactive protein, soluble TNF␣ receptors 55 and 75, and leptin were measured.Macrophage inhibitory factor levels remained low normal for 6 months, during weight loss, after which they significantly increased to normal levels at 24 months postoperatively. The other inflammatory mediators remained elevated up to minimally 3 months postoperatively; thereafter they decreased significantly. Both TNF␣ receptors remained elevated up to at least 12 months postoperatively to decrease significantly at 2 yr postoperatively.This study demonstrates that during weight loss, after gastric restrictive surgery, inflammatory mediators remain elevated for at least 3 months postoperatively, suggesting initially an ongoing inflammatory state. However, 2 yr after surgery, the inflammatory mediators reach near normal values.These findings may be an explanation for the reduced comorbidity seen in morbidly obese patients after gastric restrictive surgery. (J Clin Endocrinol Metab 89: [4062][4063][4064][4065][4066][4067][4068] 2004)

show abstract

“…Ceruloplasmin increases LDL oxidation in cell-free systems as well as in cultured cell lines, suggesting a prooxidant role (283,284). In contrast, transferrin levels decrease during infection (285). Transferrin, which binds iron, may be antioxidant, as removal of HDL particles that contain transferrin activity reduces the ability of HDL to protect against LDL oxidation (280).…”

Section: Hdl Metabolismmentioning

confidence: 99%

Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host

Khovidhunkit

Kim

Memon

et al. 2004

Journal of Lipid Research

1,291

1,200

View full text Add to dashboard Cite

Endotoxemia and acute-phase proteins in major abdominal surgery

Cited by 75 publications

References 32 publications

A single intravenous dose of endotoxin rapidly alters serum lipoproteins and lipid transfer proteins in normal volunteers

A single intravenous dose of endotoxin rapidly alters serum lipoproteins and lipid transfer proteins in normal volunteers

Macrophage Inhibitory Factor, Plasminogen Activator Inhibitor-1, Other Acute Phase Proteins, and Inflammatory Mediators Normalize as a Result of Weight Loss in Morbidly Obese Subjects Treated with Gastric Restrictive Surgery

Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host

Contact Info

Product

Resources

About