EndoTOFPET-US: a novel multimodal tool for endoscopy and positron emission tomography

Aubry, Nicolas; Auffray, E.; Mimoun, F B; Brillouet, Nicolas; Bugalho, R.; Charbon, Edoardo; Charles, O; Cortinovis, Diego; Courday, P; Cserkaszky, Aron; Damon, C; Doroud, K.; Fischer, Jannis; Fornaro, Giulia Alice; Fourmigué, Jean-Marie; Frisch, B.; Furst, B.; Gardiazabal, José; Gadow, Karsten; Garutti, E.; Gaston, C; Gil-Ortiz, A; Guedj, Éric; Harion, Tobias; Jarron, P.; Kabadanian, J; Lasser, Tobias; Laugier, R.; Lecoq, P.; Lombardo, Diego; Mandai, Shingo; Mas, Eric; Meyer, T. C.; Mundler, O.; Navab, Nassir; Ortigao, Catarina; Paganoni, M.; Perrodin, D.; Pizzichemi, Marco; Prior, John O.; Reichl, Tobias; Reinecke, Mathias; Rolo, Manuel; Schultz-Coulon, Hans-Christian; Schwaiger, Markus; Shen, Wei; Silenzi, A.; Silva, J C; Silva, R; Schweiger, Ian Somlai; Stamen, R.; Traub, Joerg; Varela, J.; Veckalns, V.; Vidal, Vincent; Vishwas, J; Wendler, Thomas; Cheng, Xu; Ziegler, Sibylle; Zvolský, M.

doi:10.1088/1748-0221/8/04/c04002

Cited by 27 publications

(16 citation statements)

References 4 publications

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“…The cooled air flows over the copper plates of the DMs and stabilizes the temperature of the DMs to (19.0 ± 0.5) °C. The readout electronics is based on the TOF-PET Application Specific Integrated Circuit (ASIC) [2,3]. TOFPET ASIC is a low-noise and low-power 64-channel mixed-mode chip with fully digital output designed in 130 nm CMOS technology for SiPM readout, developed in the framework of the EndoTOFPET-US project [3].…”

Section: Description Of the Demonstratormentioning

confidence: 99%

“…The PET demonstrator has 16 compact Detector Modules (DM). Each DM has two ASICs reading 128 SiPM pixels in one-to-one coupling to 128 Lutetium Yttrium Orthosilicate (LYSO) crystals measuring 3.1x3.1x15 mm 3 each. The data acquisition system for the demonstrator has two Front End Boards type D (FEB/D), each collecting the data of 1'024 channels (8 DMs), and transmitting assembled data frames through a serial link (4.8Gbps), to a single Data Acquisition (DAQ) board plugged into the Peripheral Component Interconnect Express (PCIe) bus of the data acquisition PC.…”

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Validation of a highly integrated SiPM readout system with a TOF-PET demonstrator

et al. 2016

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We have developed a highly integrated, fast and compact readout electronics for Silicon Photomultiplier (SiPM) based Time of Flight Positron Emission Tomography (TOF-PET) scanners. The readout is based on the use of TOP-PET Application Specific Integrated Circuit (PETsys TOFPETl ASIC) with 64 channels, each with its amplifier, discriminator, Time to Digital Converter (TDC) and amplitude determination using Time Over Threshold (TOT). The ASIC has 25 ps r.m.s. intrinsic time resolution and fully digital output. The system is optimised for high rates, good timing, low power consumption and low cost. For validating the readout electronics, we have built a technical PET scanner, hereafter called "demonstrator", with 2'048 SiPM channels. The PET demonstrator has 16 compact Detector Modules (DM). Each DM has two ASICs reading 128 SiPM pixels in one-to-one coupling to 128 Lutetium Yttrium Orthosilicate (LYSO) crystals measuring 3.1x3.1x15 mm 3 each. The data acquisition system for the demonstrator has two Front End Boards type D (FEB/D), each collecting the data of 1'024 channels (8 DMs), and transmitting assembled data frames through a serial link (4.8Gbps), to a single Data Acquisition (DAQ) board plugged into the Peripheral Component Interconnect Express (PCIe) bus of the data acquisition PC. Results obtained with this PET demonstrator are presented.

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Section: Description Of the Demonstratormentioning

confidence: 99%

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confidence: 99%

Validation of a highly integrated SiPM readout system with a TOF-PET demonstrator

et al. 2016

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“…In order to obtain the intended image quality for early detections, the system user requirements cover several technological challenges: 1 mm image spatial resolution, unprecedented 200 ps coincidence time resolution (CTR) for enhanced background rejection, online tracking of both detectors and image reconstruction with partial volume information from an asymmetric geometry [3] [4].…”

Section: Introductionmentioning

confidence: 99%

Asymmetric Data Acquisition System for an Endoscopic PET-US Detector

Zorraquino

Bugalho

Rolo

et al. 2016

IEEE Trans. Nucl. Sci.

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According to current prognosis studies of pancreatic cancer, survival rate nowadays is still as low as 6% mainly due to late detections. Taking into account the location of the disease within the body and making use of the level of miniaturization in radiation detectors that can be achieved at the present time, EndoTOFPET-US collaboration aims at the development of a multimodal imaging technique for endoscopic pancreas exams that combines the benefits of high resolution metabolic information from Time-Of- Flight (TOF) Positron Emission Tomography (PET) and anatomical information from ultrasound (US). A system with such capabilities calls for an application-specific high-performance Data Acquisition System (DAQ) able to control and readout data from two different detectors

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“…In order to obtain the intended image quality for early detections, the system user requirements cover several technological challenges: 1 mm image spatial resolution, unprecedented 200 ps Coincidence Time Resolution (CTR) for enhanced background rejection, online tracking of both detectors and image reconstruction with partial volume information from an asymmetric geometry [3][4].…”

Section: Introductionmentioning

confidence: 99%

“…1). Similar US endoscopic systems in combination with PET scanners are under investigation [2], nevertheless ENDOTOFPET-US is the first scanner that miniaturizes a PET detector to introduced it inside the patient body to cope with the image quality requirements of the application.In order to obtain the intended image quality for early detections, the system user requirements cover several technological challenges: 1 mm image spatial resolution, unprecedented 200 ps Coincidence Time Resolution (CTR) for enhanced background rejection, online tracking of both detectors and image reconstruction with partial volume information from an asymmetric geometry [3][4].A system with such characteristics demands a highperformance application-specific Data Acquisition (DAQ) system able to configure, control and readout data simultaneously from two different detectors. …”

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Asymmetric Data Acquisition System for an endoscopic PET-US detector

Zorraquino

Bugalho

Rolo

et al. 2014

2014 19th IEEE-NPSS Real Time Conference

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Abstract-According to current prognosis studies of pancreatic cancer, survival rate nowadays is still as low as 6% mainly due to late detections. Taking into account the location of the disease within the body and making use of the level of miniaturization in radiation detectors that can be achieved at the present time, EndoTOFPET-US collaboration aims at the development of a multimodal imaging technique for endoscopic pancreas exams that combines the benefits of high resolution metabolic information from Time-Of-Flight (TOF) Positron Emission Tomography (PET) with anatomical information from ultrasound (US). A system with such capabilities calls for an application-specific high-performance Data Acquisition System (DAQ) able to control and readout data from different detectors. The system is composed of two novel detectors: a PET head extension for a commercial US endoscope placed internally close to the Region-Of-Interest (ROI) and a PET plate placed over the patient's abdomen in coincidence with the PET head. These two detectors will send asymmetric data streams that need to be handled by the DAQ system. The approach chosen to cope with these needs goes through the implementation of a DAQ capable of performing multi-level triggering and which is distributed across two different on-detector electronics and the off-detector electronics placed inside the reconstruction workstation.This manuscript provides an overview on the design of this innovative DAQ system and, based on results obtained by means of final prototypes of the two detectors and DAQ, we conclude that a distributed multi-level triggering DAQ system is suitable for endoscopic PET detectors and it shows potential for its application in different scenarios with asymmetric sources of data. I. INTRODUCTIONOTIVATED by the high mortality rates for pancreatic cancer, the location of the organ under study (close to an open cavity) and current possibilities on detector radiation miniaturization, the EndoTOFPET-US collaboration conceived to create an endoscopic PET scanner in order to provide to physicians with a tool to study newest specific biomarkers for pancreatic and prostatic cancer. This novel scanner aims to push current limitations of whole body PET detectors, making possible detections of millimetric lesions. The standout characteristic of this system is its Region-OfInterest (ROI) specific configuration, which breaks with the traditional whole body scheme thanks to the incorporation of a PET detector head in an endoscopic probe (see Fig. 1). Similar US endoscopic systems in combination with PET scanners are under investigation [2], nevertheless ENDOTOFPET-US is the first scanner that miniaturizes a PET detector to introduced it inside the patient body to cope with the image quality requirements of the application.In order to obtain the intended image quality for early detections, the system user requirements cover several technological challenges: 1 mm image spatial resolution, unprecedented 200 ps Coincidence Time Resolution (CTR) for enhanced back...

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EndoTOFPET-US: a novel multimodal tool for endoscopy and positron emission tomography

Abstract: To cite this article: N Aubry et al 2013 JINST 8 C04002 View the article online for updates and enhancements.

Cited by 27 publications

References 4 publications

Validation of a highly integrated SiPM readout system with a TOF-PET demonstrator

Validation of a highly integrated SiPM readout system with a TOF-PET demonstrator

Asymmetric Data Acquisition System for an Endoscopic PET-US Detector

Asymmetric Data Acquisition System for an endoscopic PET-US detector

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