Endothelium-Derived Factors Influence Differentiation of Fat-Derived Stromal Cells Post-Exercise in Subjects with Prediabetes

Kundu, Nabanita; Domingues, Cleyton C.; Nylen, Eric; Paal, Edina; Kokkinos, Peter; Sen, Sabyasachi

doi:10.1089/met.2018.0121

Cited by 13 publications

(6 citation statements)

References 19 publications

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“…Adipose tissue also harbors fat-derived mesenchymal stem cells which experimentally have the capacity to modify mRNA expression contributing to IR [79]. Moreover, abdominal fat and fat-derived mesenchymal stem cells are responsive to physical activity; both high-intensity aerobic and resistance training decrease visceral fat effectively [80] while the molecular expression of fat-derived mesenchymal stem cells is significantly altered with exercise preventing adipogenesis [81].…”

Section: Mechanisms Underlying the Metabolic Syndrome And Implicatmentioning

confidence: 99%

Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome

Myers

Kokkinos²,

Nyelin³

2019

Nutrients

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390

225

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Both observational and interventional studies suggest an important role for physical activity and higher fitness in mitigating the metabolic syndrome. Each component of the metabolic syndrome is, to a certain extent, favorably influenced by interventions that include physical activity. Given that the prevalence of the metabolic syndrome and its individual components (particularly obesity and insulin resistance) has increased significantly in recent decades, guidelines from various professional organizations have called for greater efforts to reduce the incidence of this condition and its components. While physical activity interventions that lead to improved fitness cannot be expected to normalize insulin resistance, lipid disorders, or obesity, the combined effect of increasing activity on these risk markers, an improvement in fitness, or both, has been shown to have a major impact on health outcomes related to the metabolic syndrome. Exercise therapy is a cost-effective intervention to both prevent and mitigate the impact of the metabolic syndrome, but it remains underutilized. In the current article, an overview of the effects of physical activity and higher fitness on the metabolic syndrome is provided, along with a discussion of the mechanisms underlying the benefits of being more fit or more physically active in the prevention and treatment of the metabolic syndrome.

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Section: Mechanisms Underlying the Metabolic Syndrome And Implicatmentioning

confidence: 99%

Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome

Myers

Kokkinos²,

Nyelin³

2019

Nutrients

Self Cite

390

225

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“…The process will help to identify genes and cell differentiation pathways that may change fat derived stem cell differentiation, following exercise training in the elderly and the young subject cohorts, which will subsequently influence the mesenchymal *Address all correspondence to: ssen1@gwu.edu structures of our body. Our study [25] appears to indicate that exercise promotes osteogenic differentiation but not myogenic differentiation in the middle-aged veteran population with mean age of 51 years. However, whether osteogenic differentiation of adipose tissue derived mesenchymal stromal cells (MSCs) also occurs in young and the elderly is unknown.…”

Section: Endothelium and Endothelial Progenitor Cellsmentioning

confidence: 49%

The Role of Physical Activity on Insulin Resistance-Associated Endothelial Dysfunction

Gandhi¹,

Nylen²,

Sen³

2020

Vascular Biology - Selection of Mechanisms and Clinical Applications

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Enhanced physical activity and cardiorespiratory fitness significantly impact morbidity and mortality across the spectrum of noncommunicative chronic illnesses experienced by modern lifestyles. Physical activity itself prompts an intricate interplay of physiological responses across vital organ systems including microvascular adaptations to optimize nutrient, oxygen, and hormone delivery, some of which involves insulin-mediated regulation. Insulin has been known to act on the vasculature in multiple ways by its effects on endothelium and skeletal muscle blood flow. This is important to understand as it has implications for conditions associated with insulin resistance (IR) such as obesity, metabolic syndrome, prediabetes, diabetes, and polycystic ovarian syndrome among others. These conditions are associated with increased morbidity and mortality contributed by endothelial dysfunction via increased atherosclerosis, hypertension, and increased free fatty acid levels. In this chapter, we will discuss the effects of insulin on the vasculature, IR on the endothelium, and lastly, what impact physical activity may have on such processes.

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“…This mechanism averts the risk of metabolic syndrome and was supported by the Diabetes Prevention Program study ( 55 ). Physical activity is also reported to enhance the adipose fuel metabolism because abdominal fat and fat-derived mesenchymal stem cells are more responsive to physical activity, preventing adipogenesis ( 56 ). More such evidence-based intervention planning needs to be generated through large-scale longitudinal studies and genome-wide association studies.…”

Section: Discussionmentioning

confidence: 99%

Association Between Anthropometric Risk Factors and Metabolic Syndrome Among Adults in India: A Systematic Review and Meta-Analysis of Observational Studies

et al. 2022

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Introduction Several studies have explored the effect of anthropometric risk factors on metabolic syndrome. However, no systematic effort has explored the effect of overweight and obesity on the prevalence of metabolic syndrome in India. Thus, we undertook a meta-analysis to estimate the effect of anthropometric risk factors on the prevalence of metabolic syndrome. Methods We searched databases PubMed Central, EMBASE, MEDLINE, and Cochrane library and search engines ScienceDirect and Google Scholar, from January 1964 through March 2021. We used the Newcastle–Ottawa scale to assess the quality of published studies, conducted a meta-analysis with a random-effects model, and reported pooled odds ratios (OR) with 95% CIs. Results We analyzed 26 studies with a total of 37,965 participants. Most studies had good to satisfactory quality on the Newcastle–Ottawa scale. Participants who were overweight (pooled OR, 5.47; 95% CI, 3.70–8.09) or obese (pooled OR, 5.00; 95% CI, 3.61–6.93) had higher odds of having metabolic syndrome than those of normal or low body weight. Sensitivity analysis showed no significant variation in the magnitude or direction of outcome, indicating the lack of influence of a single study on the overall pooled estimate. Conclusion Overweight and obesity are significantly associated with metabolic syndrome. On the basis of evidence, clinicians and policy makers should implement weight reduction strategies among patients and the general population.

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Endothelium-Derived Factors Influence Differentiation of Fat-Derived Stromal Cells Post-Exercise in Subjects with Prediabetes

Cited by 13 publications

References 19 publications

Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome

Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome

The Role of Physical Activity on Insulin Resistance-Associated Endothelial Dysfunction

Association Between Anthropometric Risk Factors and Metabolic Syndrome Among Adults in India: A Systematic Review and Meta-Analysis of Observational Studies

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