Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta

Ushida, Yusuke; Matsui, Toshiro; Tanaka, Mitsuru; Matsumoto, Kiyoshi; Hosoyama, Hirokazu; Mitomi, Atsuhiro; Sagesaka, Yuko M.; Kakuda, Takami

doi:10.1016/j.jnutbio.2007.09.005

Cited by 38 publications

(23 citation statements)

References 27 publications

(33 reference statements)

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“…Pre-incubation of THP-1 cells with VPP significantly decreased the PMA-induced adhesion of THP-1 cells to HUVECs. In addition, buckwheat and safflower seed extracts have been evaluated for their potential vasorelaxation action (Ushida et al, 2008;Koyama et al, 2009). Comparison with these food components suggests that CCH is useful, not only as a supplement, but also in daily foods, such as easily cooked stews and soups.…”

Section: Methodsmentioning

confidence: 99%

Chicken Collagen Hydrolysate-derived Peptides Inhibit Tumor Necrosis Factor-α-induced Inflammatory Response in Endothelial Cells

Kouguchi

Ito

Iwai

et al. 2012

FSTR

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Novel peptides derived from chicken collagen hydrolysate (CCH) were confirmed to have a vasoprotective effect after ingestion and absorption to vessels; however, their endovascular mechanism of action required clarification. Therefore, using human umbilical vein endothelial cells (HUVECs), in which inflammation had been induced by tumor necrosis factor-α (TNF-α), we investigated the mechanism by which CCH-derived peptides inhibited the vascular inflammatory response. Expression of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and interleukin-8 (IL-8) in HUVECs was increased significantly by the addition of TNF-α, whereas treatment with proline-hydroxyproline (Pro-Hyp) and hydroxyproline-glycine (Hyp-Gly), which are present in human peripheral blood after ingestion of CCH, inhibited these increases. These peptides also reduced the mRNA expression of inducible nitric oxide synthase (iNOS) up-regulated by TNF-α. These results suggest that the vasoprotective effect of CCH-derived peptides is due to inhibition of endothelial inflammation.

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Section: Methodsmentioning

confidence: 99%

Chicken Collagen Hydrolysate-derived Peptides Inhibit Tumor Necrosis Factor-α-induced Inflammatory Response in Endothelial Cells

Kouguchi

Ito

Iwai

et al. 2012

FSTR

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“…It has been demonstrated that the bark, fruits, seeds or leaves of this plant collected from various regions of the world and administered in different pharmaceutical preparations (e.g. tinctures and aqueous extracts) decrease blood glucose levels in diabetic animals [42] and that polyphenolic compounds, including flavonoids and phenolic acids have various physiological functions, such as antioxidant, antihyperglycemic and antihypertensive properties [43].…”

Section: Introductionmentioning

confidence: 99%

<i>Syzygium cumini</i> Extract Decrease Adenosine Deaminase, 5′Nucleotidase Activities and Oxidative Damage in Platelets of Diabetic Patients

Bona

Bellé

Sari

et al. 2010

Cell Physiol Biochem

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Diabetes mellitus, a chronic metabolic disorder, has assumed epidemic proportions and its long-term complications can have devastating consequences. The oxidative stress in diabetes was greatly increased due to prolonged exposure to hyperglycemia and impairment of oxidant/antioxidant equilibrium. Syzygium cumini is being widely used to treat diabetes by the traditional practitioners over many centuries. Adenosine deaminase (ADA) and 5′-Nucleotidase (5′NT) are enzymes of purine nucleoside metabolism that play an important role in the regulation of adenosine (Ado) levels. In this study, we investigated the effect of Syzygium cumini aqueous leaves extract (ASc) on ADA and 5′NT activities and on parameters of oxidative stress under in vitro conditions, using platelets of patients with Type 2 diabetes mellitus. Platelet-Rich Plasma (PRP) was assayed by ADA, 5′NT, Catalase (CAT), Superoxide Dismutase (SOD) activities and Thiobarbituric acid reactive substances (TBARS) levels. We observed that ADA, 5′NT activities and TBARS levels were significantly higher when compared to the control group, and ASc (100 and 200 µg/mL) prevented these effects. Our study demonstrates that ASc was able to remove oxidant species generated in diabetic conditions and modulates in the Ado levels. Then, ASc may promote a compensatory response in platelet function, improving the susceptibility-induced by the diabetes mellitus.

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“…[1] Recent studies on polyphenolic compounds, including flavonoids and phenolic acids, have shown diverse functions, including antioxidant, antiulcer, antihyperglycemic, and antihypertensive properties. [2] Flavonoids are one of the important groups of polyphenolic substances that are abundantly distributed in the plant kingdom and have shown their potential to act in the gastrointestinal tract as antiulcer, antispasmodic, antisecretory or antidiarrheal agents. [3] Flavonoids in different studies have been seen to inhibit the enzyme activity of histidine decarboxylase, and thus, decrease the formation of histamine in the gastric mucosa.…”

mentioning

confidence: 99%

Rutin exerts antiulcer effect by inhibiting the gastric proton pump

Dubey¹,

Ganeshpurkar²,

Shrivastava³

et al. 2013

Indian J Pharmacol

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Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta

Cited by 38 publications

References 27 publications

Chicken Collagen Hydrolysate-derived Peptides Inhibit Tumor Necrosis Factor-α-induced Inflammatory Response in Endothelial Cells

Chicken Collagen Hydrolysate-derived Peptides Inhibit Tumor Necrosis Factor-α-induced Inflammatory Response in Endothelial Cells

<i>Syzygium cumini</i> Extract Decrease Adenosine Deaminase, 5′Nucleotidase Activities and Oxidative Damage in Platelets of Diabetic Patients

Rutin exerts antiulcer effect by inhibiting the gastric proton pump

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