Endothelins and dopamine levels in tears for assessment of neurovascular disorders in glaucoma

Павленко, Т. А.; Kim, A. R.; Kurina, A.; Davydova, N G; Kolomojceva, E M; Чеснокова, Н. Б.; Ugrumov, M. V.

doi:10.17116/oftalma201813404141

Cited by 10 publications

(4 citation statements)

References 20 publications

(24 reference statements)

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“…3,[8][9][10][11] In a study analyzing the ET-1 levels in tears in patients with glaucoma, the mean ET-1, level was 2.74±0.99 pg/mL in healthy controls, which is similar to our findings. 26 In a rabbit study, the concentration of ET-like immunoreactivity was found to be 13.85±3.94 pg/mL and 15-fold higher than that in plasma. 27 Endothelium may secrete ET-1 in various tissues.…”

Section: Discussionmentioning

confidence: 91%

Could tear endothelin-1 levels be associated with disability in multiple sclerosis?

Mustafa çam,

Sehitoglu

2023

NeuroAsia

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Background: Endothelin-1 (ET-1) is a potent vasoconstrictor substance mainly secreted by endothelial cells. Increased ET-1 levels in plasma or cerebrospinal fluid (CSF) have been identified in multiple sclerosis (MS). We aimed to analyze tear ET-1 levels; visual evoked potential (VEP) and disability scores in patients with MS and in healthy controls. Methods: Adult patients (18-65 year-old) diagnosed with MS according to the McDonald criteria, and healthy controls were recruited for the study. Demographic features, VEP, and tear ET-1 levels were evaluated. Disability in the MS group was assessed and grouped by EDSS score (<3 vs. ≥3). The EDSS score in healthy controls was zero. Results: Both in the total number of patients overall and in the patients with EDSS score <3, tear ET-1 levels were higher in the MS group than that in the controls (p<0.001). In the MS group, the ET-1 level was higher in the patients with EDSS score ≥3 than in those with EDSS score <3 (p<0.001). The tear ET-1 level was positively correlated with age and EDSS score in the MS group (p<0.001). Conclusion: To the best of our knowledge, there is no study in the literature that measures tear ET-1 levels in MS and examines their relationship with EDSS score and VEP. Higher tear ET-1 levels seem to be associated with disability and abnormal VEP in MS. Tear ET-1 measurement may be a simple new noninvasive marker indicating the disability in the patients with MS in the future.

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Section: Discussionmentioning

confidence: 91%

Could tear endothelin-1 levels be associated with disability in multiple sclerosis?

Mustafa çam,

Sehitoglu

2023

NeuroAsia

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“…The risk of developing glaucoma by patients with PD increases by 30% [ 79 ]. The concentration of catecholamines, including dopamine, in aqueous humor and lacrimal fluid was found to be decreased in patients with glaucoma compared to healthy people, attesting to the fact that glaucoma causes a dysfunctioning of the dopaminergic system of the eye [ 79 , 104 ]. The etiology of glaucoma, as well as that of PD, is multifactorial.…”

Section: Eye Disorders During Pd (Glaucoma and Cataract): Clinicalmentioning

confidence: 99%

Molecular Mechanisms and Clinical Manifestations of Catecholamine Dysfunction in the Eye in Parkinson’s Disease As a Basis for Developing Early Diagnosis

et al. 2020

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This review provides information onthe non-motor peripheral manifestations of Parkinsons disease (PD) associated with a pathology of the visual analyzer and the auxiliary apparatus of the eye. The relationship between neurodegenerative processes that take place in the brain and in the eye opens new prospects to use preventive ophthalmologic examination todiagnose PD long before the characteristic motor symptoms appear. This will encourage the use of neuroprotective therapy, which stops, or at least slows down, neuronal death, instead of the current replacement therapy with dopamine agonists. Animportant result of an eye examination of patients with PD may be a non-invasive identification of new peripheral biomarkers manifesting themselvesas changes in the composition of the lacrimal fluid.

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“… 6 Numerous studies have confirmed the presence of symptoms of visual dysfunction in patients with PD. 7 − 9 Moreover, visual dysfunction has been reported as a potential biomarker with high specificity in the early stage of neurodegenerative diseases. 10 , 11 In recent years, retinal degeneration in patients with PD has received widespread research attention and has become one of the research hotspots in the field of neurodegenerative diseases.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Study of rd1Mouse Brain and Association with Parkinson’s Disease

Zhou,

Yang,

et al. 2024

ACS Omega

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Degeneration of the retina is intrinsically associated with the pathogenesis and progression of neurodegenerative diseases. However, the cellular and molecular mechanisms underlying the association between neurodegeneration and retinal degeneration are still under exploration due to the complexity of the connectivity network of the nervous system. In this study, RNA-seq data from the brains of model retinitis pigmentosa (RP) mice and previously studied Parkinson's disease (PD) mice were analyzed to explore the commonalities between retinal degenerative and neurodegenerative diseases. Differentially expressed genes in RP were compared with neurodegenerative disease-related genes and intersecting genes were identified, including Cnr1 and Septin14. These genes were verified by quantitative realtime reverse transcription PCR and Western blotting experiments. The key proteins CNR1 and SEPTIN14 were found to be potential cotherapeutic targets for retinal degeneration and neurodegenerative disease. In conclusion, understanding the commonalities between retinal degenerative diseases and neurodegenerative processes in the brain will not only facilitate the interpretation of the underlying pathomechanisms but also contribute to early diagnosis and the development of new therapeutic strategies.

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Endothelins and dopamine levels in tears for assessment of neurovascular disorders in glaucoma

Cited by 10 publications

References 20 publications

Could tear endothelin-1 levels be associated with disability in multiple sclerosis?

Could tear endothelin-1 levels be associated with disability in multiple sclerosis?

Molecular Mechanisms and Clinical Manifestations of Catecholamine Dysfunction in the Eye in Parkinson’s Disease As a Basis for Developing Early Diagnosis

Transcriptome Study of rd1Mouse Brain and Association with Parkinson’s Disease

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