Endothelin Plasma Levels in Burn Patients

McMillen, Marvin A.

doi:10.1001/archsurg.136.9.1084

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…In this study, improved tissue survival correlated with increased Na-KATPase decreased malondialdehyde/oxidative damage and reduced inflammation in the zone of stasis [ 46 ]. Other agents have been studied to target endothelin, a vasoconstrictor peptide that regulates systemic blood flow and is elevated in severe burns, causing ischemia and subsequent tissue necrosis [ 47 ]. TAK-044, a nonselective endothelin A, and endothelin B receptor antagonist were explored in a rat burn model in 1997 [ 48 ], and one administration of TAK-044 (1 mg/kg) significantly reduced the area of necrosis [ 48 ].…”

Section: Ischemiamentioning

confidence: 99%

Therapeutic Strategies to Reduce Burn Wound Conversion

et al. 2022

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Burn wound conversion refers to the phenomenon whereby superficial burns that appear to retain the ability to spontaneously heal, convert later into deeper wounds in need of excision. While no current treatment can definitively stop burn wound conversion, attempts to slow tissue damage remain unsatisfactory, justifying the need for new therapeutic interventions. To attenuate burn wound conversion, various studies have targeted at least one of the molecular mechanisms underlying burn wound conversion, including ischemia, inflammation, apoptosis, autophagy, generation of reactive oxygen species, hypothermia, and wound rehydration. However, therapeutic strategies that can target various mechanisms involved in burn wound conversion are still lacking. This review highlights the pathophysiology of burn wound conversion and focuses on recent studies that have turned to the novel use of biologics such as mesenchymal stem cells, biomaterials, and immune regulators to mitigate wound conversion. Future research should investigate mechanistic pathways, side effects, safety, and efficacy of these different treatments before translation into clinical studies.

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Section: Ischemiamentioning

confidence: 99%

Therapeutic Strategies to Reduce Burn Wound Conversion

et al. 2022

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“…Endothelins are vasoconstrictor peptides (produced by vascular endothelial cells) that regulate the systemic blood circulation. Plasma levels of endothelins are increased by burn injury [95], leading to progressive ischemia and necrosis. Battal et al tested whether a nonselective endothelin receptor antagonist, TAK-044 could restore blood flow and reduce secondary tissue damage [96].…”

Section: Agents That Increase Perfusionmentioning

confidence: 99%

Novel pharmacotherapy for burn wounds: what are the advancements

Hamblin

2018

Expert Opinion on Pharmacotherapy

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Introduction:The prognosis for severe burns has improved significantly over the past 50 years. Meanwhile, burns have become an affliction mainly affecting the less well-developed regions of the world. Early excision and skin grafting has led to major improvements in therapeutic outcomes. Areas covered:The purpose of this article is to survey the use of pharmacotherapy to treat different pathophysiological complications of burn injury. The author, herein, discusses the use of drug treatments for a number of systemic metabolic disturbances including hyperglycemia, elevated catabolism, and gluconeogenesis. Expert opinion:Advancements in personalized and molecular medicine will make an impact on burn therapy. Similarities between severe burns and other critically ill patients will lead to crossfertilization between different medical specialties. Furthermore, advances in stem cells and tissue regeneration will lead to improved healing and less lifelong disability. Indeed, research in new drug therapy for burns is actively progressing for many different complications.

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The burned trachea

Paul

Bueno

2003

Chest Surgery Clinics of North America

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Endothelin Plasma Levels in Burn Patients

Cited by 3 publications

References 6 publications

Therapeutic Strategies to Reduce Burn Wound Conversion

Therapeutic Strategies to Reduce Burn Wound Conversion

Novel pharmacotherapy for burn wounds: what are the advancements

The burned trachea

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