Novel pharmacotherapy for burn wounds: what are the advancements

Hamblin, Michael R.

doi:10.1080/14656566.2018.1551880

Cited by 26 publications

(19 citation statements)

References 199 publications

(187 reference statements)

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“…89 The treatment of each type of these burn injuries may be affected by their specific features such as degree of burn, cause of the burn, patient's general condition, and preexisting comorbidities. 91 The wound healing process is an attempt to restore the disturbed anatomical and functional integrity of the epidermis, dermis, and underlayers, which damaged by an injury. The healing of skin wounds is a complex physiological process that is governed by multiple cell types and chemical mediators.…”

Section: Structure and Functions Of The Skinmentioning

confidence: 99%

Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing

Mehrabi

Mesgar

Mohammadi

2020

ACS Biomater. Sci. Eng.

112

108

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The morbidity, mortality, and burden of burn victims and patients with severe diabetic wounds are still high, which leads to an extensively growing demand for novel treatments with high clinical efficacy. Biomaterial-based wound treatment approaches have progressed over time from simple cotton wool dressings to advanced skin substitutes containing cells and growth factors; however, no wound care approach is yet completely satisfying. Bioactive glasses are materials with potential in many areas that exhibit unique features in biomedical applications. Today, bioactive glasses are not only amorphous solid structures that can be used as a substitute in hard tissue but also are promising materials for soft tissue regeneration and wound healing applications. Biologically active elements such as Ag, B, Ca, Ce, Co, Cu, Ga, Mg, Se, Sr, and Zn can be incorporated in glass networks; hence, the superiority of these multifunctional materials over current materials results from their ability to release multiple therapeutic ions in the wound environment, which target different stages of the wound healing process. Bioactive glasses and their dissolution products have high potency for inducing angiogenesis and exerting several biological impacts on cell functions, which are involved in wound healing and some other features that are valuable in wound healing applications, namely hemostatic and antibacterial properties. In this review, we focus on skin structure, the dynamic process of wound healing in injured skin, and existing wound care approaches. The basic concepts of bioactive glasses are reviewed to better understand the relationship between glass structure and its properties. We illustrate the active role of bioactive glasses in wound repair and regeneration. Finally, research studies that have used bioactive glasses in wound healing applications are summarized and the future trends in this field are elaborated.

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Section: Structure and Functions Of The Skinmentioning

confidence: 99%

Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing

Mehrabi

Mesgar

Mohammadi

2020

ACS Biomater. Sci. Eng.

112

108

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“…The search for effective treatment of burns has continued for many years [10]. Since the ancient times, means for local application, which still remain an important component of a comprehensive program of health care for patients with similar injuries, are mentioned as available materials.…”

Section: Resultsmentioning

confidence: 99%

Clinical and Microbiological Substantiation of Topical Application of Sorption Hydrophilic/Hydrophobic Composition Based on Nanosilica in the Treatment of Patients With Burns

et al. 2021

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Relevance.One of the promising methods of treatment of patients with burns is the local use of sorption agents with antimicrobial properties. Objective: experimental study of antimicrobial properties and clinical evaluation of the effectiveness of local use of a new sorption composition based on nanosilica in the complex treatment of patients with burns. Materials and methods. The suggested sorption nanocomposition included highly dispersed silicon dioxide, polymethylsiloxane, decamethoxine, metronidazole. The experimental study involved the study of the antimicrobial properties of the sorption nanocomposition and antimicrobial agents which are part of it. The clinical material consisted of the results of examination of 42 patients with IIab-III degree burns with an area of 10-30% of the body surface. Depending on the tactics of local treatment, patients were divided into 2 groups: after early necrectomy, xenodermoplasty, the wound surface of the patients in the main group (n = 20) was treated with a solution of decamethoxine in combination with the same sorption powder. Treatment in the comparison group (n = 22) was similar except the use of sorption drugs. The examination included visual inspection of the injured area in combination with microbiological monitoring of the wound contents on the 3rd,7th,14th day. Results. The obtained results confirmed the sufficient antimicrobial potential of the studied sorption nanocomposition, the properties of which are not inferior to the existing antiseptics for museum and clinical strains of microorganisms and fungi. Signs of a more favorable wound healing process of the patients in the main group were observed: faster wound cleaning, less inflammatory reactions and much shorter preparation of wounds for grafting. Conclusions. The obtained results convincingly indicate the effectiveness of a multicomponent composite based on nanosilica with antimicrobial components in a comprehensive treatment of patients with burns.

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“…In addition, advances in stem cells and tissue reconstruction will enhance recovery and prevent disability during life. Moreover, pharmaceutical research aimed at preventing various effects of burn is continuously advancing 33. Participants in this qualitative study also called for proper treatment at the right time.…”

Section: Discussionmentioning

confidence: 99%

<p>Comprehensive physical domain care needs of burn patients: a qualitative study</p>

Mohammadhossini¹,

Ahmadi²,

Gheibizadeh³

et al. 2019

CCID

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IntroductionBurn patients have various physical needs. To provide full care for such patients, we need a broad range of services. The current study aims at showing the physical needs of burn patients.MethodsThe current qualitative study has been done through content analysis. The data were collected from 20 in-depth, unstructured individual interviews with hospitalized patients with burns on more than 25% of their body, nurses, physiotherapists, and psychologists. The participants were selected by purposive sampling. The data were analyzed with a conventional content analysis approach using the Elo and Kyngas method.ResultsBy analyzing the data, 7 main categories were obtained from 932 primary codes: the necessity to provide optimal physiotherapy, the necessity of the patient’s overall physical assessment, the necessity of monitoring and coordination in care, healthy nutrition for burn patients, the need for pharmacotherapy, the need for pain reliefs, and finally the theme for comprehensive physical care needs in burn patients.ConclusionAccording to the findings, by applying the extracted categories, it is possible to provide quality care based on the patient’s individual needs. This can help speed up the treatment and shorten the length of hospitalization significantly.

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Novel pharmacotherapy for burn wounds: what are the advancements

Cited by 26 publications

References 199 publications

Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing

Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing

Clinical and Microbiological Substantiation of Topical Application of Sorption Hydrophilic/Hydrophobic Composition Based on Nanosilica in the Treatment of Patients With Burns

<p>Comprehensive physical domain care needs of burn patients: a qualitative study</p>

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