“…Increased levels of ET-1 are found in acute renal failure, hypertension, heart failure, ischemic heart disease, Prinzmetal angina, pulmonary hypertension, Raynaud's disease, subarachnoid hemorrhage, cerebral vasospasm, migraine and diabetes [5,9]. EG-1 is normally found in the eye, where it is produced by the non-pigmented ciliary epithelium and is released into the intraocular liquid [10]. Its receptors are expressed upon various structures, like iris, ciliary muscle, trabecular meshwork (TM), vasculature, retinal and optic nerve astrocytes, which determines the physiological role of ET-1 in the eye [11][12][13].…”