Endothelin 1 Stimulates Ca2+-Sparks and Oscillations in Retinal Arteriolar Myocytes via IP3R and RyR-Dependent Ca2+Release

Tumelty, James; Hinds, Kevin; Bankhead, Peter; McGeown, Neil J.; Scholfield, C. Norman; Curtis, Tim M.; McGeown, J. Graham

doi:10.1167/iovs.10-6029

Cited by 17 publications

(27 citation statements)

References 46 publications

(65 reference statements)

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“…In contrast, IP 3 R inhibition elevated Ca 2ϩ spark frequency in vas deferens SMCs, although this may have occurred due to an [Ca 2ϩ ] SR elevation (233). Reports (190,218) ] i could be due to multiple factors, including differences in the amplitude of Ca 2ϩ signals generated, activation and contribution of other Ca 2ϩ channels, and regulation of IP 3 R activity by tissue-specific proteins. In summary, IP 3 R activation, sometimes with the involvement of other Ca 2ϩ channels, produces a wide variety of intracellular Ca 2ϩ signals, which control several physiological functions in SMCs.…”

Section: Cellular Regulators Of Smc Ip 3 R Activitymentioning

confidence: 95%

“…Ca 2ϩ puffs arise from the synchronous opening of ϳ30 IP 3 R channels distributed within a ϳ400-nm diameter cluster in Xenopus oocytes (170,194 (10,18,29,111,190). In isolated retinal arteriole SMCs, ET-1 increased Ca 2ϩ oscillation frequency and this elevation was inhibited by blockers of IP 3 Rs and RyRs, indicating that IP 3 R-RyR cross talk stimulates Ca 2ϩ oscillations (190,218 (249). Similarly, ANG II receptor antagonists abolished Ca 2ϩ ripples and reduced myogenic tone in tail arteries (9).…”

Section: Cellular Regulators Of Smc Ip 3 R Activitymentioning

confidence: 99%

“…Therefore, IP 3 Rmediated Ca 2ϩ ripples may be a Ca 2ϩ signal by which the local renin-angiotensin system in the arterial wall contributes to myogenic constriction (9,249 sparks, albeit in a small number of SMC types (116,190,218,252). RyR-and IP 3 R-mediated SR Ca 2ϩ release both stimulated Ca 2ϩ sparks in SMCs of choroidal and retinal arterioles, pulmonary artery, and trachea (116,190,218,252). In contrast, IP 3 R inhibition elevated Ca 2ϩ spark frequency in vas deferens SMCs, although this may have occurred due to an [Ca 2ϩ ] SR elevation (233).…”

Section: Cellular Regulators Of Smc Ip 3 R Activitymentioning

confidence: 99%

“…IP 3 R-mediated Ca 2ϩ oscillations induced airway and basilar artery contraction (10,18,67). Ca 2ϩ sparks generated by IP 3 R and RyR activation contributed to vasoconstriction in retinal and choroidal arterioles (190,218). Reports in mesenteric, pulmonary, and tail arteries, inferior vena cava, and portal vein proposed that IP 3 R-mediated Ca 2ϩ waves directly induce vasoconstriction (28, 42, 49, 76, 86, 104, 107, 108, 133, 184, 249).…”

Section: Ip 3 R Regulation Of Smc Physiological Functionsmentioning

confidence: 99%

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Inositol trisphosphate receptors in smooth muscle cells

Narayanan

Adebiyi

Jaggar

2012

American Journal of Physiology-Heart and Circulatory Physiology

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Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of tetrameric intracellular calcium (Ca2+) release channels that are located on the sarcoplasmic reticulum (SR) membrane of virtually all mammalian cell types, including smooth muscle cells (SMC). Here, we have reviewed literature investigating IP3R expression, cellular localization, tissue distribution, activity regulation, communication with ion channels and organelles, generation of Ca2+ signals, modulation of physiological functions, and alterations in pathologies in SMCs. Three IP3R isoforms have been identified, with relative expression and cellular localization of each contributing to signaling differences in diverse SMC types. Several endogenous ligands, kinases, proteins, and other modulators control SMC IP3R channel activity. SMC IP3Rs communicate with nearby ryanodine-sensitive Ca2+ channels and mitochondria to influence SR Ca2+ release and reactive oxygen species generation. IP3R-mediated Ca2+ release can stimulate plasma membrane-localized channels, including transient receptor potential (TRP) channels and store-operated Ca2+ channels. SMC IP3Rs also signal to other proteins via SR Ca2+ release-independent mechanisms through physical coupling to TRP channels and local communication with large-conductance Ca2+-activated potassium channels. IP3R-mediated Ca2+ release generates a wide variety of intracellular Ca2+ signals, which vary with respect to frequency, amplitude, spatial, and temporal properties. IP3R signaling controls multiple SMC functions, including contraction, gene expression, migration, and proliferation. IP3R expression and cellular signaling are altered in several SMC diseases, notably asthma, atherosclerosis, diabetes, and hypertension. In summary, IP3R-mediated pathways control diverse SMC physiological functions, with pathological alterations in IP3R signaling contributing to disease.

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Section: Cellular Regulators Of Smc Ip 3 R Activitymentioning

confidence: 95%

Section: Cellular Regulators Of Smc Ip 3 R Activitymentioning

confidence: 99%

Section: Cellular Regulators Of Smc Ip 3 R Activitymentioning

confidence: 99%

Section: Ip 3 R Regulation Of Smc Physiological Functionsmentioning

confidence: 99%

See 2 more Smart Citations

Inositol trisphosphate receptors in smooth muscle cells

Narayanan

Adebiyi

Jaggar

2012

American Journal of Physiology-Heart and Circulatory Physiology

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“…Confocal microscopy of intact blood vessels has shown that in many blood vessels in vitro and in situ, GPCR agonist-induced contractions are controlled mainly by asynchronous Ca 2+ wave-like oscillations. In individual myocytes, these [Ca 2+ ] i waves can be observed in Ca 2+ -free solution for a relatively long time (5-30 min) [12,13,14,15,76]. The asynchronous wave-like Ca 2+ oscillations are now recognized as a common mode of Ca 2+ signalling in the myocytes of arteries and arterioles [12,13,14,15,77].…”

Section: Ca2+ Signalling Induced By Gpcr Agonistsmentioning

confidence: 99%

Calcium Signalling in Pericytes

Burdyga

Borysova²

2014

J Vasc Res

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Recent advances in pericyte research have contributed to our understanding of the physiology and pathophysiology of microvessels. The microvasculature consists of arteriolar and venular networks located upstream and downstream of the capillaries. Arterioles are surrounded by a monolayer of spindle-shaped myocytes, while terminal branches of precapillary arterioles, capillaries and all sections of postcapillary venules are encircled by a monolayer of morphologically diverse pericytes. There are physiological differences in the response of pericytes and myocytes to vasoactive molecules, suggesting that these two vascular cell types could have different functional roles in the regulation of local blood flow. The contractile activity of pericytes and myocytes is controlled by changes of cytosolic free Ca²⁺ concentration. In this short review, we summarize our results and those of other authors on the contractility of pericytes and their Ca²⁺ signalling. We describe results regarding sources of Ca²⁺ and mechanisms of Ca²⁺ release and Ca²⁺ entry in control of the spatiotemporal characteristics of the Ca²⁺ signals in pericytes.

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Regulation of type 1 inositol 1,4,5‐triphosphate receptor by dopamine receptors in cocaine‐induced place conditioning

Kurokawa

Mizuno

Shibasaki

et al. 2011

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Recent study shows that type 1 inositol-1,4,5-triphosohate receptors (IP(3) Rs) may be involved in amphetamine-induced conditioned preference, but little is known about its role in psychological dependence on cocaine. This study investigated the role and regulation of IP(3) R-1 in mice with cocaine-induced place preference. The cocaine-induced place preference was dose-dependently inhibited by intracerebroventricular pretreatment with IP(3) R antagonists, 2-aminophenoxyethane-borate (2-APB), and xestospongin C. The levels of IP(3) R-1 in the frontal cortex and nucleus accumbens of cocaine-conditioned mice significantly increased, which was completely abolished by SCH23390 and sulpiride, selective dopamine D1 and D2 receptor antagonists, respectively. These findings suggest that IP(3) R-1-mediated intracellular signaling pathway may play an important role in the development of cocaine-induced place preference and that the expression of IP(3) R-1 is controlled by both dopamine D1 and D2 receptors in the frontal cortex and nucleus accumbens of mice with cocaine-induced place preference.

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Endothelin 1 Stimulates Ca²⁺-Sparks and Oscillations in Retinal Arteriolar Myocytes via IP₃R and RyR-Dependent Ca²⁺Release

Cited by 17 publications

References 46 publications

Inositol trisphosphate receptors in smooth muscle cells

Inositol trisphosphate receptors in smooth muscle cells

Calcium Signalling in Pericytes

Regulation of type 1 inositol 1,4,5‐triphosphate receptor by dopamine receptors in cocaine‐induced place conditioning

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