Regulation of type 1 inositol 1,4,5‐triphosphate receptor by dopamine receptors in cocaine‐induced place conditioning

Abstract

Recent study shows that type 1 inositol-1,4,5-triphosohate receptors (IP(3) Rs) may be involved in amphetamine-induced conditioned preference, but little is known about its role in psychological dependence on cocaine. This study investigated the role and regulation of IP(3) R-1 in mice with cocaine-induced place preference. The cocaine-induced place preference was dose-dependently inhibited by intracerebroventricular pretreatment with IP(3) R antagonists, 2-aminophenoxyethane-borate (2-APB), and xestospongin C. The levels of IP(3) R-1 in the frontal cortex and nucleus accumbens of cocaine-conditioned mice significantly increased, which was completely abolished by SCH23390 and sulpiride, selective dopamine D1 and D2 receptor antagonists, respectively. These findings suggest that IP(3) R-1-mediated intracellular signaling pathway may play an important role in the development of cocaine-induced place preference and that the expression of IP(3) R-1 is controlled by both dopamine D1 and D2 receptors in the frontal cortex and nucleus accumbens of mice with cocaine-induced place preference.

Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor–inositol 1,4,5-trisphosphate–transient receptor potential canonical channel pathways

“…σ 1 R activation potentiates not only IP 3 R-mediated Ca 2+ release from the ER [24], but also IP 3 formation [38, 39]. IP 3 R blockade at central levels inhibits cocaine-induced place preference in mice [40]. Cocaine binds to σ 1 Rs with a 2 μM affinity [9].…”

Possible involvement of type 1 inositol 1,4,5-trisphosphate receptors up-regulated by dopamine D1 and D2 receptors in mouse nucleus accumbens neurons in the development of methamphetamine-induced place preference

“…Recent investigation demonstrates that enhancement of dopaminergic neurons in rat ventral tegmental area by IP 3 Rs-1 is an essential step for consequent behavioral changes and that this step may be involved in amphetamine-induced conditioned preference (Ahn et al, 2010). In addition, we have recently reported that intracerebroventricular injection of IP 3 R antagonists blocks the initiation of cocaine-induced place preference and that expression of IP 3 R-1 is controlled by both D1-like and D2-like dopamine receptors (D1 and D2 DRs) in the frontal cortex and limbic forebrain including the NAcc of mice (Kurokawa et al, 2012b). However, there is little data as to the role and dynamics of IP 3 Rs-1 in the NAcc and prefrontal cortex in the development of METH-induced place.…”

Regulatory Mechanisms and Pathophysiological Significance of IP3 Receptors and Ryanodine Receptors in Drug Dependence

“…In addition, a previous study demonstrated that enhancement of activity of dopaminergic neurons in the rat ventral tegmental area by IP 3 R-1 stimulation is an essential step for subsequent behavioral changes and that this step probably is involved in amphetamine-induced rewarding effect (22). Similarly, our recent studies show that both methamphetamine and cocaine, well known psychostimulants, upregulate IP 3 Rs-1 in association with strengthening of their rewarding effect and that the increases of the rewarding effect in response to both agents were significantly suppressed by the IP 3 Rs antagonists 2-aminoethoxydiphenyl borate (2-APB) and xestospongin C. In addition, both events, IP 3 R-1 upregulation and the increase of the rewarding effect, were significantly suppressed by antagonists selective to dopamine D 1 -and D 2 -like receptors (23,24). Taken together these data indicates that IP 3 R-1 upregulation in NAcc and cortex via dopamine D 1 -and D 2 -like receptors is likely to be one of the mechanisms responsible for the rewarding effect.…”