1991
DOI: 10.1507/endocrj1954.38.339
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Endothelin-1 and Endothelin-3 Stimulate Prostaglandin E2 Secretion from the Rat Median Eminence.

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Cited by 3 publications
(1 citation statement)
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“…It has been reported that specific binding sites for ET-1 are coupled to phosphoinositides with consequent intracellular accumulation of inositol triphosphate and diacylglycerol and protein kinase C activation (Resink et al 1989;Marsden et al 1989). According to these findings recent reports indicate that ET-1 is able to stimulate the release of eicosanoids from the rat median eminence (Osuga et al 1991) (1990), observing that IND suppressed -1-induced corticosteroid secretion from the adrenal gland, suggested that in adrenocortical cells prostanoids may be involved in the action of ET. Data obtained in the present study showing that ET-1 stimulates PGE release by rat Leydig cells confirm the stimulatory effect of such a peptide on the metabolism of eicosanoids observed in other target cells.…”
Section: Discussionmentioning
confidence: 97%
“…It has been reported that specific binding sites for ET-1 are coupled to phosphoinositides with consequent intracellular accumulation of inositol triphosphate and diacylglycerol and protein kinase C activation (Resink et al 1989;Marsden et al 1989). According to these findings recent reports indicate that ET-1 is able to stimulate the release of eicosanoids from the rat median eminence (Osuga et al 1991) (1990), observing that IND suppressed -1-induced corticosteroid secretion from the adrenal gland, suggested that in adrenocortical cells prostanoids may be involved in the action of ET. Data obtained in the present study showing that ET-1 stimulates PGE release by rat Leydig cells confirm the stimulatory effect of such a peptide on the metabolism of eicosanoids observed in other target cells.…”
Section: Discussionmentioning
confidence: 97%