Endothelial Protection and Viscoelastic Retention During Phacoemulsification and Intraocular Lens Implantation

Glasser, David B.; Osborn, David; Nordeen, Joanne F.; Min, Yuan‐I

doi:10.1001/archopht.1991.01080100118055

Cited by 55 publications

(16 citation statements)

References 13 publications

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“…This difference in MT may depend on rheologic properties of the OVDs such as adhesion, retention, and temperature transmission. The findings in this study are supported by the finding of McDermott et al 12 that the amount of adherent OVD is highly dependent on its type and by the finding of Glasser et al 13 regarding the greater intraocular retentive tendency of Viscoat than of cohesive OVDs such as Provisc. Moreover, Viscoat has 3 negative charges per molecular unit that provide a greater neutralizing effect on positively charged ocular tissue, which better explains the coatability of the corneal endothelium.…”

Section: Discussionsupporting

confidence: 88%

Quantitative thermographic analysis of viscoelastic substances in an experimental study in rabbits

Jurowski

Goś

Kusmierczyk

et al. 2006

Journal of Cataract and Refractive Surgery

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Section: Discussionsupporting

confidence: 88%

Quantitative thermographic analysis of viscoelastic substances in an experimental study in rabbits

Jurowski

Goś

Kusmierczyk

et al. 2006

Journal of Cataract and Refractive Surgery

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“…Of note, the endothelial cell decreases for several OVDs are between 0.3% and 20.32%. Our results are comparable with those in other investigations published in the literature [3,5-9,16,20-25]. …”

Section: Discussionsupporting

confidence: 92%

“…Dispersive OVDs are expected to cause less endothelial cell loss, as they protect better the corneal endothelium. This is in line with Glasser et al who observed less endothelial cell loss in eyes receiving Viscoat than in those receiving 1% sodium hyaluronate (Healon ® OVD, AMO), a cohesive OVD [20]. On the contrary, Holzer et al suggested that 2.3% sodium hyaluronate (Healon ® 5, OVD, AMO) had lower mean endothelial cell loss in comparison with Viscoat, while Lane et al found similar amounts of endothelial cell loss in eyes receiving cohesive and dispersive OVDs [5,21].…”

Section: Discussionsupporting

confidence: 89%

Viscoat versus Visthesia during phacoemulsification cataract surgery: corneal and foveal changes

2011

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BackgroundOphthalmic viscosurgical devices (OVDs) are widely used in phacoemulsification cataract surgery to maintain adequate intraocular space, stabilize ocular tissue during the operation and decrease the possible damage of the corneal endothelium. Our study has the purpose to compare the corneal and foveal changes of Viscoat and Visthesia in patients undergoing uneventful phacoemulsification cataract surgery.MethodsParticipants in our study were 77 consecutive patients, who were randomized into two groups based on type of OVD used during phacoemulsification: Viscoat or Visthesia. All patients underwent a complete ophthalmological examination i.e., measurement of best corrected visual acuity (BCVA) by means of Snellen charts, intraocular pressure examination by Goldmann tonometry, slit lamp examination, fundus examination, optical coherence tomography, specular microscopy and ultrasound pachymetry preoperatively and at three time points postoperatively (day 3, 15, 28 postoperatively). The differences in baseline characteristics, as well as in outcomes between the two groups were compared by Mann-Whitney-Wilcoxon test and Student's t-test, as appropriate.ResultsIntraoperatively, there was no statistically significant difference in the duration of the ultrasound application between the two groups, while Viscoat group needed more time for the operation performance. It is also worthy to mention that Visthesia group exhibited less intense pain than patients in Viscoat group. Postoperatively, there was a statistically significant difference in central corneal thickness, endothelial cell count and macular thickness between the two groups, but BCVA (logMAR) did not differ between the two groups.ConclusionsOur study suggests that Viscoat is more safe and protective for the corneal endothelium during uneventful phacoemulsification cataract surgery, while Visthesia is in superior position regarding intraoperative pain. Patients of both groups acquired excellent visual acuity postoperative. Finally, this is the first study comparing OVDs in terms of macular thickness, finding that Visthesia cause a greater increase in macular thickness postoperatively than Viscoat, although it reaches normal ranges in both groups.

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“…1 The ability of an OVD to coat the surface of endothelial cells and adequately maintain anterior chamber space is considered critical for endothelial protection. [2][3][4][5] In a study of cataract surgery using rabbits, 2 corneal endothelial cell damage after phacoemulsification was significantly lower when the OVD was retained. In that study, the presence or absence of an OVD following cataract surgery was assessed subjectively.…”

mentioning

confidence: 99%

Quantitative assessment of ophthalmic viscosurgical device retention using in vivo confocal microscopy

Petroll¹,

Jafari²,

Lane³

et al. 2005

Journal of Cataract and Refractive Surgery

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Endothelial Protection and Viscoelastic Retention During Phacoemulsification and Intraocular Lens Implantation

Cited by 55 publications

References 13 publications

Quantitative thermographic analysis of viscoelastic substances in an experimental study in rabbits

Quantitative thermographic analysis of viscoelastic substances in an experimental study in rabbits

Viscoat versus Visthesia during phacoemulsification cataract surgery: corneal and foveal changes

Quantitative assessment of ophthalmic viscosurgical device retention using in vivo confocal microscopy

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