Endothelial Microparticles Correlate with Endothelial Dysfunction in Obese Women

Abstract

EMP are elevated in obese women and independently involved in the pathogenesis of endothelial dysfunction. WHR is the anthropometric measure more closely related to EMP and endothelial dysfunction.

Microparticles as Biomarkers of Vascular Dysfunction in Metabolic Syndrome and its Individual Components

“…Multiple regression analysis showed also strong independent association between platelet-derived microparticle levels and BMI [16]. Previous work by Esposito and colleagues [67] characterized circulating levels of platelet-and endothelial-derived microparticles and FMD in 41 obese and 40 normal weight women. Obese women, when compared to lean controls, had increased circulating amounts of both platelet-and endothelial-derived microparticles and reduced values for FMD.…”

“…In that study, BMI did not correlate with either platelet-or endothelial-derived microparticles, while waist-to-hip ratio significantly correlated with both types of microparticles. The impairment of FMD in obese women demonstrated a robust correlation with both platelet-and endothelial-derived microparticles; however, multivariate analysis indicated that only endothelial microparticles were an independent predictor of impaired endothelium-dependent vasodilation [67]. Strategies to reduce weight have been shown to modulate the numbers of specific sub-populations of circulating microparticles that are increased in obese subjects, further indicating a link between overweight/obesity and the elevation of circulating microparticles.…”

Childhood obesity–related endothelial dysfunction: an update on pathophysiological mechanisms and diagnostic advancements

“…In the largest study to date, involving 844 adults without a history of cardiovascular disease, EMP counts strongly correlate with cardio-metabolic risk factors, in particular with dyslipidemia (69). Indeed in obese adults, numbers of EMP are increased and also negatively correlated with macrovascular endothelial function (70). Likewise, obese children have higher blood EMP than their normalweight counterparts (71).…”

Endothelial Dysfunction Caused by Circulating Microparticles from Patients with Metabolic Syndrome

“…23 According to Arteaga and colleagues, 19 the increase in endothelial MPs results from endothelial cell apoptosis but not activation among patients with MS. Endothelial MPs correlate with endothelial dysfunction appreciated by loss of endothelium-dependent flow-mediated vasodilatation in obese women but the mechanism involved has not been analyzed yet. 30 Endothelial dysfunction is the primary event leading to the failure of vasoactive, anti-coagulant, and anti-inflammatory effects of healthy endothelium. The most important mechanism for endothelial dysfunction is the decrease in NO availability.…”