Endothelial injury is closely related to osteopontin and TNF receptor-mediated inflammation in end-stage renal disease

Batko, Krzysztof; Krzanowski, Marcin; Gajda, Mariusz; Dumnicka, Paulina; Fedak, Danuta; Woziwodzka, Karolina; Sułowicz, Władysław; Kuźniewski, Marek; Litwin, Jan A.; Krzanowska, Katarzyna

doi:10.1016/j.cyto.2019.05.016

Cited by 15 publications

(14 citation statements)

References 47 publications

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“…Currently, several SIR markers can be identified, the concentration of which in the blood is strongly linked to the dynamics of chronic renal failure in general. These factors include accumulation in the blood [ 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 ] of the following: various ROS; proinflammatory cytokines: TNF-α, IL-6, and IL-18; chemokines: IL-8 (CXCL8), IL-34, SDF1α (CXCL12), MCP-1 (CCL2), and MIP-1β (CCL4); growth factors: GM-CSF (granulocyte-macrophage colony-stimulating factor), FGF-23, and HGF (hepatocyte growth factor); soluble forms of receptors: sTNFR1 and sTNFR2, sCD40L, and sCD163 (SR-I3); cyclophilin A as an inducer of proinflammatory cytokines [ 186 ]. …”

Section: Systemic Inflammatory Processes In Esrdmentioning

confidence: 99%

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

Гусев

Соломатина

Zhuravleva

et al. 2021

IJMS

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Chronic kidney disease can progress to end-stage chronic renal disease (ESRD), which requires the use of replacement therapy (dialysis or kidney transplant) in life-threatening conditions. In ESRD, irreversible changes in the kidneys are associated with systemic changes of proinflammatory nature and dysfunctions of internal organs, skeletal muscles, and integumentary tissues. The common components of ESRD pathogenesis, regardless of the initial nosology, are (1) local (in the kidneys) and systemic chronic low-grade inflammation (ChLGI) as a risk factor for diabetic kidney disease and its progression to ESRD, (2) inflammation of the classical type characteristic of primary and secondary autoimmune glomerulonephritis and infectious recurrent pyelonephritis, as well as immune reactions in kidney allograft rejection, and (3) chronic systemic inflammation (ChSI), pathogenetically characterized by latent microcirculatory disorders and manifestations of paracoagulation. The development of ChSI is closely associated with programmed hemodialysis in ESRD, as well as with the systemic autoimmune process. Consideration of ESRD pathogenesis from the standpoint of the theory of general pathological processes opens up the scope not only for particular but also for universal approaches to conducting pathogenetic therapies and diagnosing and predicting systemic complications in severe nephropathies.

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Section: Systemic Inflammatory Processes In Esrdmentioning

confidence: 99%

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

Гусев

Соломатина

Zhuravleva

et al. 2021

IJMS

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“…Nonetheless, CAD patients were characterized by an increased oxidative stress status and impaired endothelial function associated with a NO bioavailability reduction ( Abdel-Azeez and Al-Zaky, 2010 ; Yang and Ming, 2013 ; Incalza et al, 2018 ). Recently some authors reported that high OPN levels could in some way interfere with vessel endothelial function ( Shemyakin et al, 2012 ; Batko et al, 2019 ; Maniatis et al, 2019 ). – In this study, we investigated the relationship between OPN, oxidative stress, and endothelial dysfunction taking into account the arginine metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…It has also been shown that increased levels of reactive oxygen species, in patients with CAD, lead to a progressive endothelial dysfunction ( Incalza et al, 2018 ). Furthermore, it has been shown that endothelial vascular function impairment is associated with high OPN levels ( Shemyakin et al, 2012 ; Schreier et al, 2016 ; Batko et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease

et al. 2020

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Introduction Osteopontin (OPN) is involved in ectopic calcification. Its circulating form is upregulated in coronary artery disease (CAD) patients. Circulating OPN levels positively correlate with oxidative stress, one of the major triggers of endothelial dysfunction. Endothelial dysfunction is, in turn, associated with reduced nitric oxide (NO) bioavailability due to the impaired arginine pathway. The aim of this study was to better understand the correlations between OPN, oxidative stress markers, and the arginine pathway metabolites. Methods and Results ELISA and mass spectrometry techniques have been used to evaluate circulating OPN and arginine pathway/oxidative stress metabolites, respectively, in twenty-five control subjects and thirty-three patients with overt atherosclerosis. OPN positively correlates with 2,3-dinor-8isoPGF2a levels ( p = 0.02), ornithine ( p = 0.01), ADMA ( p = 0.001), SDMA ( p = 0.03), and citrulline ( p = 0.008) levels only in CAD patients. In addition, citrulline positively correlated with ADMA ( p = 0.02) levels, possibly as result of other sources of citrulline biosynthetic pathways. Conclusion The association between OPN and impaired arginine/NO pathway could play a role in the inhibition of endothelial NO synthase (eNOS) and/or in the arginase activation in the context of CAD patients. However, further studies are needed to verify the cause-effect relationship between OPN, oxidative stress, and arginine/NO pathway dysregulation.

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“…This adds to our earlier report on the association between medial arterial calcification and SDF -1 and sTM levels. 6,23 The levels of SDF -1 and sTM were also shown to be positively correlated with matrix alterations (high grade of alcian blue staining). Thrombomodulin is a PG lining the endothelial…”

Section: Associations Between Histological Staining and Laboratory Mamentioning

confidence: 96%

Proteoglycan/glycosaminoglycan and collagen content in the arterial wall of patients with end-stage renal disease – new indicators for vascular disease

Batko

Krzanowski

Gajda

et al. 2019

Polish Archives of Internal Medicine

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INTRODUCTION The prevalence of cardiovascular (CV) comorbidity in patients with chronic kidney disease (CKD) is high, particularly in end-stage renal disease (ESRD). There is an ongoing search for novel biomarkers of CV disease in this population. OBJECTIVES We aimed to investigate the associations of matrix proteoglycans (PGs) and glycosaminoglycans (GAGs), collagen, and arterial calcifications with selected serum and plasma markers of endothelial dysfunction, inflammation, oxidative stress, and bone turnover in patients with ESRD. PATIENTS AND METHODS We enrolled 47 adult patients (32 men) with stage 5 CKD. The following parameters were investigated: fibrinogen, soluble thrombomodulin (sTM), plasminogen activator inhibitor 1 (PAI-1), stromal cell-derived factor 1α (SDF-1α), calcium (Ca), phosphate (Pi), intact parathormone, interleukin 6, high-sensitivity C-reactive protein (hs-CRP), ferric reducing ability of plasma, 2,2-diphenyl-1-picrylhydrazyl scavenging, ferric reducing ability of ascorbate in plasma, fetuin-A, fibroblast growth factor 23, osteopontin, osteoprotegerin, osteocalcin, transforming growth factor β (TGF-β), hepatocyte growth factor, secreted protein acidic and rich in cysteine, as well as matrix metalloproteinase 2. Radial artery specimens were stained with alizarin red for calcifications, alcian blue for PGs and GAGs, and sirius red for collagen. RESULTS We observed positive correlations between PG and GAG, collagen, and calcification staining. The most intense (grade 3) alcian blue staining was significantly correlated with diabetes as well as higher levels of Ca × Pi product, hs-CRP, fibrinogen, SDF-1α, PAI-1, and sTM. However, PAI-1 was the only significant predictor of grade 3 alcian blue staining in a multiple logistic regression model adjusted for hemodialysis, Ca× Pi product, and hs-CRP levels. CONCLUSIONS Coagulation disorders and endothelial dysfunction are the hallmarks of ESRD. The levels of SDF-1α, PAI-1, sTM, and fibrinogen may be novel predictors of early vascular wall alterations and may serve as CV risk markers.

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Endothelial injury is closely related to osteopontin and TNF receptor-mediated inflammation in end-stage renal disease

Cited by 15 publications

References 47 publications

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease

Proteoglycan/glycosaminoglycan and collagen content in the arterial wall of patients with end-stage renal disease – new indicators for vascular disease

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