Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease

Moschetta, Donato; Minno, Matteo Nicola Dario Di; Porro, Benedetta; Perrucci, Gianluca Lorenzo; Valerio, Vincenza; Alfieri, Valentina; Massaiu, Ilaria; Orekhov, Alexander N.; Minno, Alessandro Di; Songia, Paola; Cavalca, Viviana; Myasoedova, Veronika A.; Poggio, Paolo

doi:10.3389/fphys.2020.00982

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…The association between OPN and impaired nitric oxide (NO) bioavailability could play a role in the inhibition of endothelial NO synthase in coronary artery disease patients [ 31 ]. Serum OPN identifies progression of coronary artery calcium scanning in patients without known atherosclerotic cardiovascular disease at baseline after 4-year follow-up [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Cohort Study of the Association between Serum Osteopontin Levels and Aortic Stiffness in Hypertensive Patients

Chang

Tsai

Wang

et al. 2022

IJERPH

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By suppressing mineralization and preventing ectopic calcium deposits, osteopontin (OPN) has an inhibitory effect on vascular calcification. Also, there is an association between OPN and aortic stiffness (AS). We aimed to investigate the association between serum OPN levels and AS measured by carotid–femoral pulse wave velocity (cfPWV) in hypertensive patients. Baseline characteristics and fasting blood sampling of 120 participants with hypertension and 120 participants without hypertension were acquired. Serum OPN concentrations were determined by enzyme-linked immunosorbent assay. In total, 43 (35.9%) participants were assigned to the AS group with cfPWV of >10 m/s in hypertensive patients. There were more patients with diabetes mellitus, old age, high systolic blood pressure, high serum intact parathyroid hormone (iPTH), elevated C-reactive protein, and high OPN levels in the AS group compared with the control group in hypertensive participants. A multivariate logistic regression analysis discloses that age, SBP, serum OPN, and iPTH levels were independently associated with AS in hypertensive patients. Moreover, according to a multivariate forward stepwise linear regression analysis, OPN level is positively associated with cfPWV. In conclusion, serum OPN level is assumed to be a potential biomarker to predict AS and is positively associated with cfPWV in patients with hypertension.

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Section: Discussionmentioning

confidence: 99%

A Retrospective Cohort Study of the Association between Serum Osteopontin Levels and Aortic Stiffness in Hypertensive Patients

Chang

Tsai

Wang

et al. 2022

IJERPH

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show abstract

“…It is well known that the impairment of endothelial function reflects the early stage of atherosclerosis, where OPN could be harmful. OPN is related to decreased activity of NO synthase (NOS) within atherosclerotic lesions, contributing to endothelial dysfunction in patients with coronary artery disease (CAD) [30]. Another study demonstrated that an OPN deficiency attenuates angiotensin II-induced aortic aneurysm and atherosclerosis in animal models [31].…”

Section: Factors Regulating the Atherogenetic Action Of Opnmentioning

confidence: 99%

The Role of Osteopontin in Atherosclerosis and Its Clinical Manifestations (Atherosclerotic Cardiovascular Diseases)—A Narrative Review

Kadoglou,

Khattab,

Velidakis

et al. 2023

Biomedicines

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Atherosclerotic cardiovascular diseases (ASCVDs) are the most common and severe public health problem nowadays. Osteopontin (OPN) is a multifunctional glycoprotein highly expressed at atherosclerotic plaque, which has emerged as a potential biomarker of ASCVDs. OPN may act as an inflammatory mediator and/or a vascular calcification (VC) mediator, contributing to atherosclerosis progression and eventual plaque destabilization. In this article, we discuss the complex role of OPN in ASCVD pathophysiology, since many in vitro and in vivo experimental data indicate that OPN contributes to macrophage activation and differentiation, monocyte infiltration, vascular smooth muscle cell (VSMC) migration and proliferation and lipid core formation within atherosclerotic plaques. Most but not all studies reported that OPN may inhibit atherosclerotic plaque calcification, making it “vulnerable”. Regarding clinical evidence, serum OPN levels may become a biomarker of coronary artery disease (CAD) presence and severity. Significantly higher OPN levels have been found in patients with acute coronary syndromes than those with stable CAD. In limited studies of patients with peripheral artery disease, circulating OPN concentrations may be predictive of future major adverse cardiovascular events. Overall, the current literature search suggests the contribution of OPN to atherosclerosis development and progression, but more robust evidence is required.

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Serum osteopontin level is independently associated with arterial stiffness in patients on hemodialysis

Huang,

Hsu,

Wang

et al. 2024

Tzu Chi Medical Journal

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Objectives: Carotid–femoral pulse wave velocity (cfPWV) is an approach primarily adopted to define arterial stiffness (AS), which is one of the major contributors to unfavorable cardiovascular outcomes. Osteopontin (OPN), in addition to regulation of bone homeostasis, is an inflammatory mediator of atherosclerosis. We performed a research which estimated the correlation between blood OPN levels and AS in participants on maintenance hemodialysis (MHD). Materials and Methods: One hundred and twenty-six patients who received long-term MHD were included in the cross-sectional study. cfPWV values were calculated based on the carotid and femoral pulsation waveforms. Patients with cfPWV >10 m/s were categorized into the AS group. We utilized a commercially available enzyme-linked immunosorbent assay to check serum concentrations of OPN. Results: Study patients belonging to AS were found to be older, had significantly higher prevalence of underlying diabetes mellitus (DM) and hypertension, had higher systolic blood pressure, and had higher serum total calcium and OPN levels. After adjusting for these variables, multivariate logistic regression analysis disclosed that OPN levels, older age, DM, and total serum calcium levels were independently correlated with AS in patients on MHD. Multivariate analysis based on forward stepwise linear regression also showed that the logarithmically transformed OPN level was an independent correlate of cfPWV in these participants. Conclusion: Serum OPN concentrations had a positive correlation with cfPWV and were therefore related to AS in patients on MHD.

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Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease

Cited by 3 publications

References 37 publications

A Retrospective Cohort Study of the Association between Serum Osteopontin Levels and Aortic Stiffness in Hypertensive Patients

A Retrospective Cohort Study of the Association between Serum Osteopontin Levels and Aortic Stiffness in Hypertensive Patients

The Role of Osteopontin in Atherosclerosis and Its Clinical Manifestations (Atherosclerotic Cardiovascular Diseases)—A Narrative Review

Serum osteopontin level is independently associated with arterial stiffness in patients on hemodialysis

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