Endothelial inclusions in dermatomyositis.

Norton, Walter L.; Velayos, Edward E.; Robison, Leslie L.

doi:10.1136/ard.29.1.67

Cited by 81 publications

(26 citation statements)

References 8 publications

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“…They have also been observed in sarcoplasmic nuclei, macrophages and muscle capillary endothelial cell cytoplasm of patients with polymyositis (9,10). In the studies of Chou (9), the intranuclear structures seen were smaller than the inclusions reported in the present study.…”

Section: Discussioncontrasting

confidence: 48%

Glomerular cytoplasmic tubular structures in renal biopsies of patients with systemic lupus erythematosus and other diseases

Hurd

Eigenbrodt

Worthen

et al. 1971

Arthritis & Rheumatism

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Virus-like structures were present in all of 42 renal biopsies from 35 patients with SLE, five of whom had normal kidney tissue by light microscopy. Structures were also present in biopsies from 24 of 113 patients with renal disease other than SLE who had been selected at random. Fourteen of these were children, and three had normal kidney tissue by light microscopy. In biopsies from eight normal volunteers, there was no evidence of the structures. Although the structures were uniformly present in the kidneys of patients with SLE, they were not specific for SLE.Myxovirus-like tubular structures have been reported with great frequency in the tissues of patients with systemic lupus erythematosus (SLE). They were first report-

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Section: Discussioncontrasting

confidence: 48%

Glomerular cytoplasmic tubular structures in renal biopsies of patients with systemic lupus erythematosus and other diseases

Hurd

Eigenbrodt

Worthen

et al. 1971

Arthritis & Rheumatism

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“…TIs were described in patients with SLE and were called lupus inclusions 40 before their recognition in patients with DM. 41 TIs correlate with increased serum interferon-␣ levels in patients with SLE and other disorders, 42,43 and they are associated with interferon-␣ treatment. 44 TIs develop in vascular endothelial cells exposed to interferon-␣ in vitro.…”

Section: Fig 5 Plasmacytoid Dendritic Cells (Pdcs) In Dermatomyositimentioning

confidence: 94%

Interferon‐α/β–mediated innate immune mechanisms in dermatomyositis

Greenberg

Pinkus

et al. 2005

Annals of Neurology

527

480

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Dermatomyositis has been modeled as an autoimmune disease largely mediated by the adaptive immune system, including a local humorally mediated response with B and T helper cell muscle infiltration, antibody and complement-mediated injury of capillaries, and perifascicular atrophy of muscle fibers caused by ischemia. To further understand the pathophysiology of dermatomyositis, we used microarrays, computational methods, immunohistochemistry and electron microscopy to study muscle specimens from 67 patients, 54 with inflammatory myopathies, 14 with dermatomyositis. In dermatomyositis, genes induced by interferon-alpha/beta were highly overexpressed, and immunohistochemistry for the interferon-alpha/beta inducible protein MxA showed dense staining of perifascicular, and, sometimes all myofibers in 8/14 patients and on capillaries in 13/14 patients. Of 36 patients with other inflammatory myopathies, 1 patient had faint MxA staining of myofibers and 3 of capillaries. Plasmacytoid dendritic cells, potent CD4+ cellular sources of interferon-alpha, are present in substantial numbers in dermatomyositis and may account for most of the cells previously identified as T helper cells. In addition to an adaptive immune response, an innate immune response characterized by plasmacytoid dendritic cell infiltration and interferon-alpha/beta inducible gene and protein expression may be an important part of the pathogenesis of dermatomyositis, as it appears to be in systemic lupus erythematosus.

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“…More than 25 years ago, tubuloreticular inclusions (also known as lupus inclusions), a unique pathological lesion in DM muscle endothelial cells, 11,12 were recognized as a downstream marker of type 1 IFN signaling. Tubuloreticular inclusions develop in patients treated with IFN-a 13,14 and in cultured endothelial and other cells directly in response to IFN-a and IFN-b, 15--17 but not IFN-g. 14 More recently, cytokine-inducible gene transcripts detected by microarrays 18--21 have been utilized as downstream markers of cytokine stimulation.…”

Section: Introductionmentioning

confidence: 99%