Glomerular cytoplasmic tubular structures in renal biopsies of patients with systemic lupus erythematosus and other diseases

Hurd, Eric R.; Eigenbrodt, Edwin H.; Worthen, Howard G.; Strunk, Stanley S.; Ziff, Morris

doi:10.1002/art.1780140414

Cited by 32 publications

(16 citation statements)

References 31 publications

(7 reference statements)

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“…All authors insist upon the high prevalence or even the constancy of the inclusions in the renal biopsies of patients with SLE (Gy6rkey, 1969;Norton, 1969;Kawano, Miller, and Kimmelstiel, 1969;Bariety and Milliez, 1970b;Haas and Yunis, 1970;Grausz, Earley, Stephens, Lee, and Hopper, 1970;Bloodworth and Shelp, 1970;Hurd, Eigenbrodt, Worthen, Strunk, and Ziff, 1971;Garancis, Komorowski, Bernhard, and Straumfjord, 1971;Tisher, Kelso, Robinson, Gunnells, and Burkholder, 1971). In the patients with SLE, identical structures were also described in the endothelial cytoplasm of muscular (Norton, 1969;Feorino, Hierholzer, and Norton, 1970), dermal (Norton, 1969;Haas and Yunis, 1970;Feorino et al, 1970;Prunieras, Grupper, Durepaire, Beltzer-Garelly, and Regnier, 1970), and synovial capillaries (Schumacher, 1970) in the lymph node tissue (Haas and Yunis, 1970) and in the cytoplasm of mononuclear cells of peripheral blood (Bariety, Amor, Kahan, Balafrej, and Delbarre, 1971;Gyorkey and Sinkovics, 1971).…”

Section: Degree Of Specificity Of the Inclusionsmentioning

confidence: 99%

Frequency of intraendothelial `virus-like' particles: An electron microscopy study of 376 human renal biopsies

et al. 1973

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SYNOPSis Intraendothelial 'virus-like' particles were found in all cases requiring a renal biopsy: in 89 % of patients with systemic lupus erythematosus (SLE), in 73 % of those receiving renal transplants more than one year before, and in 24' 5 % of all other renal biopsies.The exact nature of the intraendothelial 'virus-like' inclusions detected in the renal biopsies of patients with SLE and their degree of specificity remain highly controversial. In the present paper we hope to provide further insight into the relationship between the prevalence and the occurrence of such particles and the various conditions for which the renal biopsies were performed.

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Section: Degree Of Specificity Of the Inclusionsmentioning

confidence: 99%

Frequency of intraendothelial `virus-like' particles: An electron microscopy study of 376 human renal biopsies

et al. 1973

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“…MTS, which is reported to exist in nearly all SLE patients (98%-100%), [7][8][9] was not observed in our patient by EM, although the absence of MTS does not necessarily rule out SLE. Polyclonal B-cell activation is observed in SLE, but there is no report of elevated ASO in SLE patients.…”

Section: Discussionmentioning

confidence: 51%

Patient with diffuse mesangial and endocapillary proliferative glomerulonephritis with hypocomplementemia and elevated anti-streptolysin O treated with prednisolone, angiotensin-converting enzyme inhibitor, and angiotensin II receptor antagonist

Ito

Kuriyama

Iino

et al. 2003

Clinical and Experimental Nephrology

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A 24-year-old woman was admitted to Toyosaka Hospital with proteinuria, hematuria, lymphopenia, hypocomplementemia, positive anti-nuclear antibody (ANA), and elevation of anti-streptolysin O (ASO). Renal biopsy specimen revealed diffuse mesangial and endocapillary glomerulonephritis with crescent formation and duplication of the capillary loop on light microscopic examination. Mild to moderate proliferation of mesangial matrix and cells were observed. On immunofluorescence (IF) examination, deposition of IgG, IgA, IgM, C1q, C3, and C4 to the mesangium and capillary wall were observed. By electron microscopy (EM), mesangial, subendothelial, and subepithelial deposits were recognized. However, microtubular structure in glomerular endothelial cells, fingerprint structures, and circumferential mesangial interposition were not observed by EM. The patient was referred to our hospital, but there was no change in her proteinuria 3 weeks after admission. The elevation of ASO, hypocomplementemia, and endocapillary proliferation suggested acute glomerulonephritis, while lymphocytopenia, positive ANA, the persistent hypocomplementemia, and various deposits detected by IF and EM suggested lupus nephritis; however, she did not fulfill the classification criteria of systemic lupus erythematosus. We started prednisolone (40 mg/day) with the diagnosis of chronic glomerulonephritis revealing diffuse mesangial and endocapillary proliferative glomerulonephritis, but it was not effective for the proteinuria. Quinapril (10 mg/day) and losartan (25 to 50 mg/day) were administered and the proteinuria decreased. It is possible that this use of an angiotensin converting-enzyme inhibitor and an angiotensin II receptor antagonist was effective in reducing the proteinuria in this patient.

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“…T h e involvement of lymphocytes in 2 cases of chronic discoid lupus accords with other systemic features of this apparently localized and relatively benign disease. The frequency of vascular involvement in SLE or discoid lupus may approach 100% (6,8,22) and is probably significantly greater than in other diseases (3,4,22,23). Nevertheless, T R S have also been identified in the glomeruli of some children with nephrotic syndrome (23) and in vessels supplying neoplastic tissue (24) among other conditions reviewed previously (25,26).…”

Section: Clinical Specificity and Significance Of Trsmentioning

confidence: 95%

Abnormal Structures in Circulating Lymphocytes from Patients with Systemic Lupus Erythematosus and Related Diseases

Grimley

Decker

Michelitch

et al. 1973

Arthritis & Rheumatism

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A prospective electron microscopic study, incorporating blind controls, demonstrated tubuloreticular structures (TRS) in the buffy coat lymphocytes of 32 patients with connective tissue disease. From 1 to 8% of the lymphocyte sections were involved. The abnormal structures consisted of interwoven, electron-dense tubules (220 to 280 A diameter) which were located within the endoplasmic reticulum. Tubuloreticular structures were found in lymphocytes from 20 of 30 patients with systemic lupus erythematosus (SLE), 2 of 4 with discoid lupus erythematosus, 8 of 20 with other connective tissue disease and none of 22 control cases. Clinical evaluation of the patients with SLE disclosed no specific differences between those with TRS-positive or TRS-negative lymphocytes; there were some indications of greater disease activity in the TRS-positive group. The biologic nature of TRS is unknown, but they have been linked to virus infection under both clinical and experimental conditions. systemic lupus erythematosus (SLE) (3-6) and many patients with related diseases of connective tissues (7-9). We now report a significant frequency of morphologically identical structures in the circulating lymphocytes of such patients.T h e tubules in question have been distinguished by their ultrastructural appearance. They are relatively electron-dense and measure in the range of 220 to 280 A in diameter. They are interwoven within membrane-limited compartments which can often be identified as dilatations of the endoplasmic reticulum or perinuclear space. T h e biologic nature of these structures is still unknown, and we have adopted the description tu buloreticular struclures (TRS) also proposed by Dalton (1 0).T h e possibility of finding T R S in circulating cells was suggested by electron microscopic examination of a skin biopsy from a 24-year-old man with SLE with subcutaneous nodules and histologic evidence of chronic vasculitis. Thin

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Glomerular cytoplasmic tubular structures in renal biopsies of patients with systemic lupus erythematosus and other diseases

Cited by 32 publications

References 31 publications

Frequency of intraendothelial `virus-like' particles: An electron microscopy study of 376 human renal biopsies

Frequency of intraendothelial `virus-like' particles: An electron microscopy study of 376 human renal biopsies

Patient with diffuse mesangial and endocapillary proliferative glomerulonephritis with hypocomplementemia and elevated anti-streptolysin O treated with prednisolone, angiotensin-converting enzyme inhibitor, and angiotensin II receptor antagonist

Abnormal Structures in Circulating Lymphocytes from Patients with Systemic Lupus Erythematosus and Related Diseases

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