Endothelial function testing and cardiovascular disease: focus on peripheral arterial tonometry

Bruno, Rosa Maria; Gori, Tommaso; Ghiadoni, Lorenzo

doi:10.2147/vhrm.s44471

Cited by 43 publications

(25 citation statements)

References 66 publications

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“…To calculate the RHI, the ratio of the results of the recovery (cuff deflated) and baseline periods for the test arm (A/B) was divided by the ratio of the results of the recovery and baseline periods for the control arm (C/D), and then multiplied by the baseline correction factor [RHI = (A/B)/(C/D) x baseline correction factor] (Additional file 1: Figure S3). According to the manufacturer’s recommendation, values below 1.67 or 0.51 for the RHI or its natural logarithm of the reactive hyperemia index (LnRHI), respectively, characterize endothelial dysfunction [23]. These values are still not available in the literature for the pediatric population.…”

Section: Methodsmentioning

confidence: 99%

Vascular function in asthmatic children and adolescents

et al. 2017

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BackgroundEpidemiological studies have demonstrated an increased incidence of cardiovascular events in patients with bronchial asthma, but little is known about the relationship between asthma and vascular function. The purpose of this study was to evaluate endothelial function and arterial stiffness in children and adolescents with asthma.MethodsA cross-sectional controlled study was designed. Measurements of endothelial function and arterial stiffness in asthmatic (13.6 ± 0.6 years) and control groups (14.9 ± 0.7 years) were taken by the non-invasive peripheral arterial tonometry (EndoPAT2000) determined by using the natural logarithm of the reactive hyperemia index (LnRHI) and the augmentation index (AIx@75%), respectively. Patients with asthma were also administered two questionnaires to evaluate asthma control and quality of life. Exercise functional capacity was evaluated using the Shuttle Walking Test (SWT). Only male participants were included in the present study.ResultsLnRHI and the walked distance during the SWT were similar between groups (p = 0.23 and p = 0.50, respectively). AIx@75% was significantly higher in the asthmatic group (-7.75 ± 1.7) compared to the control group (-15.25 ± 1.8), p < 0.04. In the control group, the LnRHI correlated positively with baseline systolic blood pressure (r = 0.53, p = 0.02) and mean arterial pressure (r = 0.50, p = 0.03), age (r = 0.61, p = 0.007), weight (r = 0.63, p = 0.004) and height (r = 0.56, p = 0.015). Besides that LnRHI correlated with FVC (r = 0.69, p = 0.002), FEV1, (r = 0.53, p = 0.03) and negatively with Tiffeneau index (FEV1/FVC%, r = −0.49 p = 0.04). The LnRHI of the asthmatic group did not correlate with the different variables evaluated.ConclusionThe increased AIx@75% without changes in LnRHI in asthmatic patients could mean that an early detection of vascular impairment may precede endothelial dysfunction, and that different mechanisms may contribute to the pathogenesis and progression of cardiovascular events in this population. A large prospective and randomized controlled study should be done to evaluate the physiopathological mechanisms underlying the association between arterial stiffness and asthma.Electronic supplementary materialThe online version of this article (doi:10.1186/s12931-016-0488-3) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Vascular function in asthmatic children and adolescents

et al. 2017

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“…In addition, changes in FA appear to precede the manifestation of irreversible WM lesions (de Groot et al, 2013 ; Pelletier et al, 2015 ), and are predictive of future cerebrovascular incidents (Evans et al, 2016 ). Despite this evidence, less is known about the relationship between these neuroimaging predictors and early detectors of cardiovascular disease, such as endothelial function (Bruno et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Endothelial Function Is Associated with White Matter Microstructure and Executive Function in Older Adults

Johnson

Gold

Brown

et al. 2017

Front. Aging Neurosci.

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Age-related declines in endothelial function can lead to cognitive decline. However, little is known about the relationships between endothelial function and specific neurocognitive functions. This study explored the relationship between measures of endothelial function (reactive hyperemia index; RHI), white matter (WM) health (fractional anisotropy, FA, and WM hyperintensity volume, WMH), and executive function (Trail Making Test (TMT); Trail B − Trail A). Participants were 36 older adults between the ages of 59 and 69 (mean age = 63.89 years, SD = 2.94). WMH volume showed no relationship with RHI or executive function. However, there was a positive relationship between RHI and FA in the genu and body of the corpus callosum. In addition, higher RHI and FA were each associated with better executive task performance. Tractography was used to localize the WM tracts associated with RHI to specific portions of cortex. Results indicated that the RHI-FA relationship observed in the corpus callosum primarily involved tracts interconnecting frontal regions, including the superior frontal gyrus (SFG) and frontopolar cortex, linked with executive function. These findings suggest that superior endothelial function may help to attenuate age-related declines in WM microstructure in portions of the corpus callosum that interconnect prefrontal brain regions involved in executive function.

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“…Blood vessels and their unique structure, including the endothelium and muscular layer, are considered as a separate organ because of their ability to contract, relax, and change permeability in response to systemic and local stimulants instead of functioning as a simple tubular system. 5 , 6 Because of the effects of endothelium on vascular tonus, this condition is important in microvascular surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Blood vessels provide metabolites for cell oxygenation and nutrition and respond to both physical and chemical stimulants by changing the vessel tonus and permeability. 5 , 6 …”

mentioning

confidence: 99%

Evaluation of the Effects of Bile on the Arterial Tonus in a Rabbit Model

Temiz

Mezili

Tiftikçioğlu

et al. 2015

Plastic and Reconstructive Surgery - Global Open

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Background:Hepatic artery anastomosis is an essential part of live-donor liver transplantation, and during this anastomosis, an unusual contact between bile and vessel ends is observed. In this study, the effects of this nonphysiological contact in a rabbit model were evaluated.Methods:The study was designed in 2 steps—in vitro and in vivo. Three groups were established for the in vitro study. In the first group, vessels were incubated in Krebs solution with 5% bile for 1 minute. In the second group, vessels were kept in Krebs solution with 5% bile for 5 minutes. Vessels in the control group were kept in Krebs solution without bile. All groups were examined for responses to vasodilator and vasoconstrictor agents in organ bath system. The specimens were evaluated immunohistochemically and histopathologically. In the in vivo step, microvascular anastomosis was performed bilaterally. Right carotid artery was anastomosed during bile contamination as study group, and left carotid artery was anastomosed without bile contamination as control group. Blood flow indexes were measured.Results:The results of the in vitro study revealed decreased responses to contractile and relaxing agents in the first study group compared with that of the control group (P < 0.0001). There was no response obtained in the second study group. The Doppler ultrasound results revealed no difference between preoperative and postoperative flow indexes (P > 0.05). There was no postoperative spasm in the study group. However, there was significant vasospasm in the control group (P < 0.05).Conclusions:Vessels exposed to bile have decreased contractile and relaxing responses, and this effect increases with exposure duration.

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Endothelial function testing and cardiovascular disease: focus on peripheral arterial tonometry

Cited by 43 publications

References 66 publications

Vascular function in asthmatic children and adolescents

Vascular function in asthmatic children and adolescents

Endothelial Function Is Associated with White Matter Microstructure and Executive Function in Older Adults

Evaluation of the Effects of Bile on the Arterial Tonus in a Rabbit Model

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