Endothelial Dysfunction of Vessels at Lung Cancer

Abstract

Aim: To evaluate changes in indicators of endothelial function and their relationship with morphological forms of disease, stage of pathological process and tumor markers, by analysis the peripheral blood of lung cancer (LC) patients. Materials and Methods: 38 LC patients without metastases (mean age — 57 years) prior chemo- and radiotherapy were included in the study. The duration of the disease manifestation was 18 months. 21% of patients had small cell LC, and the rest — non-small cell LC. The ratio of patients with stages IA, IB, IIA, IIB, IIIA and IIIB LC was 1 : 3 : 3 : 4 : 4 : 4. The enzyme immunoassay, spectrophotometry, and statistical data analysis were used. Results: Endothelial dysfunction of vessels was characterized by increased blood levels of vascular endothelial growth factor (VEGF), endothelin-1 (ET1), homocysteine (HCys), cyclic guanosine monophosphate (cGMP), P-selectin (PSel) and nitrites (NO2) and simultaneously by decreased values of prostacyclin (PgI2). Those were observed in 100; 90; 76; 71; 50; 53 and 79% of LC cases, respectively. Disturbances of vascular endothelial function were associated with patient’s age, disease duration, and morphological form and LC stage. Such changes were observed in women with higher prevalence. The studied indices correlated with tumor markers, namely transforming growth factor beta (TGFβ1), fibronectin and osteopontin. Conclusion: Indices of vascular endothelial dysfunction in LC can be of diagnostic and prognostic value.

The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from Healthy Subjects

“…It was shown that the use of these tools could provide fast and reliable diagnosis of di erent types of cancers in clinical settings. Another study [13] obtained similar results, where increased P-selectin value di ered signi cantly from the levels in healthy individuals. e carcinoma mucin induces microthrombi formation and triggers platelet activation and [22,23].…”

“…It was recognized that P-selectin may be a candidate involved in the metastatic process [8][9][10]. ere are studies reporting that P-selectin plays a functional role in metastasis formation in breast, colon [11,12], and lung cancers [10,13]. ere was a study which explained a deeper role of P-selectin.…”

Salvia miltiorrhiza Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress

“…These indices of increasing VEGF and ET-1 and decreasing PGI2 were observed in most lung cancer cases. Disturbances of vascular endothelial function were associated with the patient's age, disease duration, morphological form, and lung cancer stage [60]. Angiotensin II (Ang II), as a powerful vasoconstrictor for controlling blood pressure and vascular remodeling, has also been shown to have important inflammatory and oxidative actions in the endothelium [61,62].…”

Platelets in aging and cancer—“double-edged sword”

“…TxA 2 in turn promotes metastasis of various tumor models by increasing TCIPA, endothelial cell activation, and recruitment of innate immune cells, all contributing to creating a pre-metastatic niche [178]. Targeting COX1/TxA 2 appears efficient to reduce tumor cell metastasis [179,180]. Conversely, prostacyclin, one of the most potent platelet inhibitors, prevents metastasis in a melanoma model [176,178].…”