Salvia miltiorrhiza Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress

Cheng, Yu‐Chen; Hung, I-Ling; Liao, Yen-Nung; Hu, Wen-Long; Hung, Yu‐Chiang

doi:10.3390/life11111257

Cited by 8 publications

(5 citation statements)

References 104 publications

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“…Zingiberis Rhizoma (Gan-Jiang) shows anti-fatigue effects by exciting the adrenal cortex system 41 and regulates the abundances and interactions in the gut microbiota 42 . Salviae Miltiorrhizae Radix et Rhizoma (Dan-Shen) protects endothelial dysfunction against mitochondrial oxidative stress, and exhibits cardiovascular and cerebrovascular protective actions 43 . Acori Tatarinowii Rhizoma (Shi-Chang-Pu) exerts regulatory effects on the neurotransmitter levels, antioxidant stress responses, oxygen free radical scavenging, downregulation of inflammatory mediators, inhibition of neuronal apoptosis, and modulation of neuroglial cells and blood-brain barrier permeability 44 .…”

Section: Discussionmentioning

confidence: 99%

Clinical effects of traditional Chinese herbal medicine management in patients with COVID-19 sequelae: A hospital-based retrospective cohort study in Taiwan

Hsieh,

Yu,

Tzeng

et al. 2024

Int. J. Med. Sci.

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Introduction: An estimated 43% of COVID-19 patients showed sequelae, including fatigue, neurocognitive impairment, respiratory symptoms, and smell or taste disorders. These sequelae significantly affect an individual's health, work capacity, healthcare systems, and socioeconomic aspects. Traditional Chinese herbal medicine (TCHM) management showed clinical benefits in treating patients with COVID-19 sequelae. This study aimed to analyze the effects of personalized TCHM management in patients with COVID-19 sequelae. Methods: After the COVID-19 outbreak in Taiwan, we recorded Chronic Obstructive Pulmonary Disease Assessment Tool (CAT), Chalder Fatigue Questionnaire (CFQ-11), and Brief Symptom Rating Scale (BSRS-5) to assess post-COVID respiratory, fatigue, and emotional distress symptoms, respectively. In this study, we retrospectively reviewed the medical records between July 2022 and March 2023. We analyzed the effects of TCHM administration after 14- and 28-days of treatment. Results: 47 patients were included in this study. The results demonstrated that personalized TCHM treatment significantly improved the CAT, CFQ-11, and BSRS-5 scores after 14 and 28 days. TCHM alleviated physical and psychological fatigue. In logistic regression analysis, there was no statistically significant differences in the severity of the baseline symptoms and TCHM administration effects concerning the duration since the initial confirmation of COVID-19, sex, age, or dietary preference (non-vegetarian or vegetarian). Conclusions: Our study suggested that personalized TCHM treatment notably reduced fatigue, respiratory and emotional distress symptoms after 14- and 28-days of treatment in patients with COVID-19 sequelae. We propose that TCHM should be considered as an effective intervention for patients with COVID-19 sequelae.

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Section: Discussionmentioning

confidence: 99%

Clinical effects of traditional Chinese herbal medicine management in patients with COVID-19 sequelae: A hospital-based retrospective cohort study in Taiwan

Hsieh,

Yu,

Tzeng

et al. 2024

Int. J. Med. Sci.

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“…When combined with A mongholicus Bunge, S miltiorrhiza Bunge can activate the PI3K/ AKT signaling pathway and inhibit the TLR4/nuclear factor κB signaling pathway, resulting in significant anti-inflammatory and antioxidant effects. [29,30] In this study, we identified 46 chemical constituents from the BATMAN-TCM database, including compounds such as neotanshinone C, tanshiquinone B, miltionone I, neocryptotanshinone II, and dihydrokaranone. It has been observed that the main chemical components can interact with other active compounds on multiple targets within the network.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology identifies the inhibitory effect of Yiqiyangyinquyu prescription on salivary gland inflammation in Sjögren’s syndrome

Hong,

Chen,

Ren

et al. 2023

Medicine

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This study aimed to explore the mode of action of Yiqiyangyinquyu prescription (YP) against Sjögren’s syndrome (SS) by combining network pharmacology with molecular docking techniques. YP’s active components and target proteins were identified using the BATMAN-traditional Chinese medicine database. Concurrently, targets associated with SS were extracted from databases, including Genecards, Online Mendelian Inheritance in Man, and Therapeutic Target Database. The standard targets were then imported into the STRING database to construct a protein-protein interaction network. We then conducted gene ontology and Kyoto encyclopedia of genes and genomes enrichment analyses, which were succeeded by molecular docking studies to validate core active components and key targets. Finally, in vitro experiments and molecular dynamics simulation were conducted to substantiate the therapeutic efficacy of YP in treating SS. A total of 206 intersection targets and 46 active compounds were identified. Gene ontology analysis unveiled that YP targets were primarily enriched in cellular responses to chemical stress, inflammation, and cell proliferation. Key enriched signaling pathways encompassed the interleukin 17, hypoxia-inducible factor-1, tumor necrosis factor (TNF-α), and advanced glycation end products-receptor for AGEs (AGE-RAGE) signaling pathways. Molecular docking results demonstrated high-affinity between neotanshinone C, tanshiquinone B, miltionone I, TNF-α, interleukin 1 beta (IL-1β), and interleukin 6 (IL-6). Noteworthy, TNF-α, considered the most important gene in YP against SS, binds to YP most stably, which was further validated by molecular dynamics simulation. In vitro experiments confirmed YP’s capacity to reduce TNF-α, IL-1β, and IL-6 expression, effectively alleviating SS-related inflammation. YP demonstrated a significant anti-inflammatory effect by suppressing inflammatory cytokines (TNF-α, IL-6, and IL-1β), providing experimental evidence for its clinical application in treating SS.

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“…Among the various components extracted from S. miltiorrhiza , DHT is a fat-soluble compound that exhibits anti-inflammatory effects. It is well established that DHT shows strong anti-oxidative and anti-inflammatory properties in inflammation and various other diseases 28 , 36 . In the current study, in vitro experiments demonstrated that DHT mitigates IL-1β-induced damage to human primary chondrocytes.…”

Section: Discussionmentioning

confidence: 99%

Dihydrotanshinone I protects human chondrocytes and alleviates damage from spontaneous osteoarthritis in a guinea pig model

Zhang,

Wei,

et al. 2023

Sci Rep

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Osteoarthritis (OA) is the most common degenerative joint disease. Currently, no satisfactory pharmacological treatment exists for OA. The potential anti-inflammatory properties of Dihydrotanshinone I (DHT) have been reported, but its effects on OA are unclear. In this study, we assess the impact of DHT on the viability of human chondrocytes in vitro. We then use a guinea pig model to investigate the effects of DHT on knee osteoarthritis progression. Twelve-week-old Dunkin Hartley guinea pigs spontaneously developing OA were intraperitoneally injected with different doses of DHT for eight weeks. Micro-CT analysis was performed on the subchondral bone in the knee, and histological assessment of the knee joint was done using stained sections, the ratio of hyaline to calcified cartilage, and Mankin scores. DHT successfully restored IL-1β-induced decreases in cell viability in human primary chondrocytes. In the guinea pig model, intraperitoneal injections of DHT ameliorated age-induced OA, effectively reduced the expression level of two cartilage metabolism-related genes (ADAMTS4 and MMP13) and decreased the inflammatory biomarker IL-6 in the serum of guinea pigs developing spontaneous osteoarthritis. These findings demonstrate DHT’s protective effects on chondrocytes and suggest that it alleviates cartilage degradation and proteoglycan loss in OA.

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Salvia miltiorrhiza Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress

Cited by 8 publications

References 104 publications

Clinical effects of traditional Chinese herbal medicine management in patients with COVID-19 sequelae: A hospital-based retrospective cohort study in Taiwan

Clinical effects of traditional Chinese herbal medicine management in patients with COVID-19 sequelae: A hospital-based retrospective cohort study in Taiwan

Network pharmacology identifies the inhibitory effect of Yiqiyangyinquyu prescription on salivary gland inflammation in Sjögren’s syndrome

Dihydrotanshinone I protects human chondrocytes and alleviates damage from spontaneous osteoarthritis in a guinea pig model

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