Endothelial Dysfunction, Nitric Oxide and Platelet Activation in Hypertensive and Diabetic Type II Patients

Ouviña, Susana María; Greca, Rodolfo D La; Zanaro, Noemí Luján; Palmer, Luis; Sassetti, Beatriz

doi:10.1016/s0049-3848(01)00237-7

Cited by 69 publications

(44 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Accumulating evidence suggests that NO formation catalyzed by iNOS is involved in insulin resistance. In diabetic patients, increased NO levels correlate with TNF-α, HbA1c, and platelet activation (21). The levels of nitrate, nitrite, nitrotyrosine, iNOS, and TNF-α are increased in the quadriceps muscle of type 2 diabetic patients (22).…”

Section: Discussionmentioning

confidence: 99%

Lack of Inducible Nitric Oxide Synthase Prevents Lipid-Induced Skeletal Muscle Insulin Resistance Without Attenuating Cytokine Level

et al. 2011

View full text Add to dashboard Cite

Abstract. We examined whether deletion of inducible nitric oxide synthase (iNOS) could prevent lipid infusion-induced insulin resistance in iNOS-knockout and wild-type mice with the in vivo euglycemic-hyperinsulinemic clamp technique. Plasma NO metabolites were increased in lipid-infused wild-type mice, while they were not increased in iNOS-knockout mice. Plasma tumor necrosis factor-α levels were increased in both wild-type and iNOS-knockout by lipid-infusion. Lipid infusion reduced glucose infusion rate (GIR) and whole body glucose uptake in wild-type mice, whereas iNOS-knockout mice displayed comparable GIR and whole body glucose uptake compared with the control. In the gastrocnemius, lipid infusion decreased glucose uptake and glycolysis that were accompanied with increased phosphorylation of c-Jun N-terminal kinase and reduced phosphorylation of phosphoinositide 3-kinases and serine/threonine kinase Akt. However, lipid infusion did not affect glucose uptake or phosphorylation of these proteins in iNOS-knockout mice. The mRNA levels of inflammatory cytokines were also increased in the gastrocnemis of wild-type and iNOS-knockout mice by lipid infusion. Nitrotyrosine level in the gastrocnemius was increased in lipid-infused wild-type mice but it was not increased in iNOS-knockout mice. These results suggest that lack of iNOS prevents lipid infusion-induced skeletal muscle insulin resistance without attenuating cytokine levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Lack of Inducible Nitric Oxide Synthase Prevents Lipid-Induced Skeletal Muscle Insulin Resistance Without Attenuating Cytokine Level

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Yugar-Toledo et al [36] found that patients with diabetes showed an increase in plasma nitrite/nitrate levels, suggesting an association with excessive production and/or inactivation of NO. Ouviña et al [37] analyzed endothelial dysfunction and NO levels in patients with hypertension and in patients who suffered from both hypertension and diabetes. They found an increase in the NO levels of patients with hypertension and diabetes together, hence indicating that there is increased release of NO but maybe, low NO bioavailability.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Jalali

Phadke

2011

Ind J Clin Biochem

View full text Add to dashboard Cite

Conditions like hypertension, atherosclerosis and diabetes are known to be the result of endothelial dysfunction which could begin early in the life of an individual. The markers of endothelial dysfunction studied in the present work are plasma hemoglobin, serum high sensitivity C-reactive protein (hsCRP) and plasma nitrite and nitrate. We studied the onset of endothelial dysfunction with increase in age as well as in disease condition like newly detected hypertensives and of hypertensive diabetic patients. The mean plasma hemoglobin and hsCRP values were found to increase with age. hsCRP and plasma hemoglobin levels were significantly higher in patient groups as compared to aged-matched controls. On the other hand nitrate and nitrite was significantly higher in patients who suffered from both diabetes and hypertension together and nitrate values were significantly lower in patients who suffered from hypertensive alone. Plasma hemoglobin and hsCRP are associated with endothelial dysfunction and increases both with age as well as in disease condition.

show abstract

“…8,16 All of the patients in this study had endothelial cell dysfunction at baseline as a result of hypertension, as has been demonstrated in previous reports. 6,7 However, endothelial cell dysfunction significantly improved in approximately half of the patients after treatment. Moreover, the low-dose perindopril-indapamide combination improved left ventricular diastolic function parameters (ie, IVRT and EDT).…”

Section: Discussionmentioning

confidence: 99%

Effects of low-dose combination therapy with an angiotensin-converting enzyme inhibitor and a diuretic on flow-mediated vasodilation in hypertensive patients: a 6-month, single-center study

Seküri

Bayturan

Göçer

et al. 2003

Current Therapeutic Research

View full text Add to dashboard Cite

Background: Combination therapy with an angiotensin-converting enzyme (ACE) inhibitor and a diuretic has been shown to be highly effective in hypertension. Clinical trials have demonstrated that ACE inhibitors may improve endothelial cell dysfunction in hypertension. However, the effectiveness of the combination treatment in endothelial cell dysfunction is unknown.Objective: This study investigated the effects of a new low-dose combination, perindopril 2 mg plus indapamide 0.625 mg, on brachial artery flow-mediated vasodilation (FMD) and left ventricular diastolic function in hypertension.Methods: Patients aged 18 to 75 with newly diagnosed stage I or II hypertension were eligible. Endothelium-dependent brachial artery FMD and endotheliumindependent vasodilation were assessed at baseline. Patients were treated with oral perindopril 2 mg plus indapamide 0.625-mg tablets once daily for 6 months. FMD measurements were then repeated. Percentage changes in FMD from baseline to 6 months, as well as left ventricular diastolic function parameters (isovolumic relaxation time [IVRT] and mitral diastolic E-wave deceleration time [EDT]), indicated the effectiveness of the intervention.Results: Twenty-nine Turkish patients were enrolled (17 women, 12 men; mean [SD] age, 54.5 [9.5] years [range, 38-75 years]). The mean (SD) baseline FMD was 7.00% (2.39%) (endothelial cell dysfunction) and increased significantly to 8.68% (2.78%) at 6 months (P ϭ 0.02); FMD improved in 15 patients (51.7%). At baseline and 6 months of therapy, mean (SD) IVRT was 101.7 (12.4) ms and 95.5 (7.7) ms, respectively (P Ͻ 0.001), and EDT was 234.7 (33.9) ms and 217.9 (25.6) ms, respectively (P Ͻ 0.001).Conclusions: In this small sample of hypertensive patients, a low-dose combination ACE inhibitor and diuretic significantly improved brachial artery FMD Accepted for publication October 16, 2003October 16, . doi:10.1016October 16, /j.curtheres.2003.005 Reproduction in whole or part is not permitted.0011-393X/03/$19.00Copyright ą 2003 Excerpta Medica, Inc. CURRENT THERAPEUTIC RESEARCHand left ventricular diastolic function. The improvement in FMD values was independent of the stage of hypertension. These findings suggest a relationship between improvement in endothelial cell function and diastolic function. (Curr Ther Res Clin Exp. 2003;64:715-724)

show abstract

Endothelial Dysfunction, Nitric Oxide and Platelet Activation in Hypertensive and Diabetic Type II Patients

Cited by 69 publications

References 31 publications

Lack of Inducible Nitric Oxide Synthase Prevents Lipid-Induced Skeletal Muscle Insulin Resistance Without Attenuating Cytokine Level

Lack of Inducible Nitric Oxide Synthase Prevents Lipid-Induced Skeletal Muscle Insulin Resistance Without Attenuating Cytokine Level

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Effects of low-dose combination therapy with an angiotensin-converting enzyme inhibitor and a diuretic on flow-mediated vasodilation in hypertensive patients: a 6-month, single-center study

Contact Info

Product

Resources

About