Endothelial dysfunction links erectile dysfunction to heart disease

Kirby, Martha; Jackson, Graham; Simonsen, Ulf

doi:10.1111/j.1742-1241.2005.00453.x

Cited by 121 publications

(106 citation statements)

References 33 publications

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“…[18][19][20][21][22] Endothelial dysfunction occurs when the inner lining of the blood vessels is damaged by 23 reported that brachial artery flowmediated vasodilation (endothelium-dependent) was reduced in patients with ED (1.3%) versus those patients without ED (2.4%; P ¼ 0.014). Also, vasodilation to nitroglycerin (endothelium-independent) was reduced in ED patients (13.0%) versus non-ED patients (17.8%; Po0.05).…”

Section: Mechanisms For Links Between Ed and Coronary Artery Diseasementioning

confidence: 99%

Erectile dysfunction as a predictor of cardiovascular disease

Kloner

2008

Int J Impot Res

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Although it has been recognized that erectile dysfunction (ED) and coronary artery disease share many of the same risk factors-smoking, dyslipidemia, diabetes and hypertension-just in the past few years several new studies now suggest that ED is an important early marker of the presence of coronary artery disease. Recent analyses suggest that ED symptoms occur prior to coronary artery disease symptoms and may be a predictor of future major cardiovascular events. Some of these new studies also suggest that ED is an independent risk factor for predicting cardiovascular events-that is independent of other well-established risk factors. Taken together, these new studies suggest that when a patient presents with ED, the patient should be questioned about cardiac health and cardiovascular risk factors. If cardiovascular risk factors are identified, they should be worked up and aggressively treated-as treatment of these risk factors may be life-saving.

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Section: Mechanisms For Links Between Ed and Coronary Artery Diseasementioning

confidence: 99%

Erectile dysfunction as a predictor of cardiovascular disease

Kloner

2008

Int J Impot Res

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“…13 The role of endothelial dysfunction is well established in coronary artery disease and its risk factors. 14,15 Normal erectile function is primarily a vascular event that relies heavily on vasodilation, which occurs largely due to endothelially derived nitric oxide (NO).…”

Section: Introductionmentioning

confidence: 99%

Linking erectile dysfunction and coronary artery disease

2005

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Coronary artery disease (CAD) and erectile dysfunction (ED) are both highly prevalent conditions that frequently coexist. Additionally, they share mutual vascular risk factors, suggesting that they are both manifestations of systemic vascular disease. The role of endothelial dysfunction in CAD is well established. Normal erectile function is primarily a vascular event that relies heavily on endothelially derived, nitric oxide-induced vasodilation. Accordingly, endothelial dysfunction appears to be a common pathological etiology and mechanism of disease progression between CAD and ED. The risk factors of diabetes mellitus, hypertension, hyperlipidemia, obesity and tobacco abuse contribute to endothelial dysfunction. This article reviews the role of vascular endothelium in health, the abnormalities resulting from vascular risk factors, and clinical trials evaluating the role of endothelial dysfunction in ED.

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“…[1][2][3] One common denominator for these diseases is vascular endothelial dysfunction, and ED may be a marker for the potential development of vascular disease including myocardial infarction. [4][5][6] Vascular endothelium plays a pivotal role in pathogenesis of numerous thrombotic and inflammatory disorders. 7 In recent years, the interest for endothelial cell-derived submicroscopic membranous vesicles, termed microparticles, has substantially increased, not only because of their procoagulant properties but also because of their putative role in inflammatory processes and their ability to directly affect endothelial functions.…”

Section: Introductionmentioning

confidence: 99%

Endothelial microparticles correlate with erectile dysfunction in diabetic men

et al. 2006

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Cell-derived microparticles are supposed to be involved in endothelial dysfunction and atherogenesis. This study aimed to evaluate circulating microparticles in diabetic subjects with erectile dysfunction (ED) and their relation with endothelial dysfunction. Thirty diabetic men with ED and 20 age-matched control subjects without ED were assessed for circulating microparticles and endothelial dysfunction. Flow cytometry was used to assess microparticles by quantification of circulating endothelial (EMP, CD31 þ /CD42b À ) and platelet (PMP, CD31 þ /CD42b þ ) microparticles in peripheral blood. Endothelium-dependent flow-mediated dilation (FMD) was evaluated in the right brachial artery after reactive hyperemia. Compared with non-diabetic subjects, diabetic men presented significantly higher numbers of EMP (P ¼ 0.001), and reduced FMD (P ¼ 0.01), with a significant inverse correlation between the number of circulating EMP and the International Index of Erectile Function (IIEF) score (r ¼ À0.457, P ¼ 0.01). Multivariate analysis correcting for age, anthropometric indices, glucose and lipid parameters, FMD and PMP identified EMP as the only independent predictor for IIEF score (P ¼ 0.03). EMP are elevated in impotent diabetic subjects and independently involved in the pathogenesis of ED.

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Endothelial dysfunction links erectile dysfunction to heart disease

Cited by 121 publications

References 33 publications

Erectile dysfunction as a predictor of cardiovascular disease

Erectile dysfunction as a predictor of cardiovascular disease

Linking erectile dysfunction and coronary artery disease

Endothelial microparticles correlate with erectile dysfunction in diabetic men

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