Endothelial dysfunction in type-2 diabetics with early diabetic nephropathy is associated with low circulating adiponectin

Yılmaz, Mahmut İlker; Sağlam, Mutlu; Qureshi, Abdul Rashid; Carrero, Juan Jesús; Çağlar, Kayser; Eyıleten, Tayfun; Sönmez, Alper; Çakır, Erdinç; Oğuz, Yusuf; Vural, Abdülgaffar; Yenicesu, Müjdat; Stenvinkel, Peter; Lindholm, Bengt; Axelsson, Jonas

doi:10.1093/ndt/gfm828

Cited by 103 publications

(82 citation statements)

References 31 publications

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“…In the present study, we showed that ezetimibe treatment improved hyperlipidemia, albuminuria, and glomerular hypertrophy in db/db mice, implying a beneficial role of ezetimibe in early diabetic nephropa- Several human and animal studies have reported that hypoadiponectinemia is associated with renal dysfunction [21][22][23] . In the present study, we observed the improvement of hypoadiponectinemia by ezetimibe treatment in db/db mice; however, we did not find a correlation between the effect of ezetimibe on albuminuria and on adiponectin in db/db mice (data not shown), suggesting that improvement of hypoadiponectinemia may not be responsible for the renoprotective effect of ezetimibe in db/db mice.…”

Section: Discussionsupporting

confidence: 57%

Ezetimibe Ameliorates Early Diabetic Nephropathy in db/db Mice

Tamura

Murayama

Minami

et al. 2012

JAT

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Aim: Lipid-lowering medications have been suggested to have a potential benefit in the treatment of chronic kidney disease (CKD) such as diabetic nephropathy. Although ezetimibe has been widely used to lower serum cholesterol levels, the effect of this drug on diabetic nephropathy remains unclear. In the present study, therefore, we examined the protective effect of ezetimibe on diabetic nephropathy in db/db mice. Method: Db/db mice were fed a standard diet with 0.01% (w/w) of ezetimibe for 8 weeks from 8 weeks of age. Results: Treatment with ezetimibe did not affect food intake, body weight gain, adiposity, or blood pressure in db/db mice. Ezetimibe also had no effect on glucose metabolism such as fasting plasma glucose and insulin; however, it markedly reduced plasma lipid levels and hepatic lipid contents and reduced the urinary excretion of albumin by 50% in db/db mice, suggesting the effect of ezetimibe on diabetic nephropathy. Furthermore, ezetimibe improved glomerular hypertrophy. Although ezetimibe had no effect on oxidative stress measured by urinary 8-OHdG in db/db mice, the plasma adiponectin level was normalized, and the expression of adiponectin receptor 1 in the kidney was increased by ezetimibe treatment. Conclusion: Our data suggest that ezetimibe can improve early diabetic nephropathy through its hypolipidemic effect, and the amelioration of adiponectin resistance may also be responsible for the renoprotective effect of ezetimibe as its underlying mechanism. J Atheroscler Thromb, 2012; 19:608-618.

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Section: Discussionsupporting

confidence: 57%

Ezetimibe Ameliorates Early Diabetic Nephropathy in db/db Mice

Tamura

Murayama

Minami

et al. 2012

JAT

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show abstract

“…These results agreed with the results of Julie et al [21] and these of Ran J.et al [22] who have concluded a higher serum adiponectin concentration which was associated with reduced renal function in type 2 diabetics as the kidney was involved in the degradation and/or elimination of adiponectin, although it was unlikely to be the sole mechanism. Yilmaz et al reported that vascular endothelial dysfunction existed in untreated early diabetic nephropathy patients with severe proteinuria and decreased plasma adiponectin concentration, which was contradictory to our results.…”

Section: Methodssupporting

confidence: 93%

“…Elevated glucose levels could promote inflammation by increased oxidative stress. [22,23,24] Another possibility is that inflammatory response is a result of vascular complications following diabetes. The acute-phase response refers to a non specific and complex reaction of the individual that occurs shortly after a tissue injury.…”

Section: Methodsmentioning

confidence: 99%

Role of Adiponectin in Development and Progression of Diabetic Complications

Ismail¹

2016

jmscr

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“…However, Xiang et al (19) did not find any relation between plasma osteoprotegerin and BMI, total cholesterol, triglycerides, LDLcholesterol, or HDL-cholesterol. In contrast, OPG was positively correlated with insulin resistance in an obese population (30) and in men with T2DM. (31) Regarding ghrelin in this study, it was significantly lower in diabetic patients compared to healthy individuals.…”

Section: Discussionmentioning

confidence: 76%