Endothelial dysfunction in subjects with chronic cadmium exposure

Lukkhananan, Pinanong; Thawonrachat, Natthapong; Srihirun, Sirada; Swaddiwudhipong, Witaya; Chaturapanich, Ganyapong; Vivithanaporn, Pornpun; Unchern, Supeenun; Visoottiviseth, Pornsawan; Sibmooh, Nathawut

doi:10.2131/jts.40.605

Cited by 16 publications

(9 citation statements)

References 40 publications

(51 reference statements)

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“…The results of this study show a significant increase in ADMA after 5 weeks of Cd exposure that decreases over time until after withdrawal. This study supports evidence from clinical observations that subjects with prolonged heavy metal exposure exhibit endothelial dysfunction mediated by increased ADMA in circulation (Lukkhananan et al 2015;Ochoa-Martínez et al 2018).…”

Section: Discussionsupporting

confidence: 90%

“…Human population studies show inconsistent results. Chronic cadmium exposure in human subjects has been shown to induce endothelial impairment due to decreased nitric oxide bioavailability and increased asymmetric dimethylarginine (ADMA) (Lukkhananan et al 2015). Furthermore, human exposure to cadmium has been associated with hypertension and high cadmium body burden (Franceschini et al 2017;Garner and Levallois 2017;An et al 2017).…”

Section: Introductionmentioning

confidence: 99%

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Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine

Al‐Naemi

Das

2020

Environ Sci Pollut Res

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Cadmium (Cd) is a naturally occurring toxic heavy metal with no known essential biological functions. Exposure to Cd increases the risk of cardiovascular disease by disrupting vascular homeostasis at the endothelium. The aim of the study was to evaluate the effect of chronic low-dose Cd on vascular structure and function. Fifty adult male Sprague Dawley rats were grouped and assigned to one of two treatments for 14 weeks. The control group received normal water for 14 weeks while the Cd-treated group received 15 mg Cd/kg B.W. as CdCl 2 in water for 10 weeks. A subset of the Cd-treated group received 15 mg Cd/kg B.W. as CdCl 2 in water for 10 weeks followed by 4 weeks of normal water. Results show an overall decline in vascular function and structure. Withdrawal of Cd treatment showed a considerable restoration of vascular structure and vasorelaxation function. Additionally, asymmetric dimethylarginine (ADMA) bioavailability was found to be lowered over time. Interestingly, the expression of eNOS in the Cd-treated group was found to be significantly elevated during the exposure by more than 3-fold in comparison with that in the control group. This protein expression was similar to the control group after the withdrawal of Cd treatment. Taken together, the results suggest that ADMA, an eNOS inhibitor, may play a role in altering endothelial function in the presence of cadmium. In conclusion, the findings indicate that even at low doses, Cd leads to endothelial dysfunction mediated by ADMA.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine

Al‐Naemi

Das

2020

Environ Sci Pollut Res

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“…It has been thought Pb and Cd have role in atherosclerosis because they increase oxidative stress and inflammation, induces renal dysfunctions, effects endothelial functions and alter the nitric oxide synthesis regulation. High Pb and Cd level is also a risk factor in peripheral arterial diseases and other cardiovascular diseases [14,17,18,27].…”

Section: Discussionmentioning

confidence: 99%

Effects of age, gender, BMI, settlement and smoking on lead and cadmium accumulation in heart tissue

Dip¹,

İritaş²,

Mergen³

et al. 2017

Med-Science

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Cadmium (Cd) and lead (Pb) are well-known risk factors for peripheral arterial and some other cardiovascular diseases. The aim of the study was to determine the level of both toxic metals, in the human heart tissue and compare the accumulation to their age, gender, body mass index, living environment and smoking habit. Heart tissues of the 112 autopsy cases, representing a sample set of population living in capital city of Turkey: Ankara Province (both in city center and suburban), were collected from Turkey Ministry of Justice, Council of Forensic Medicine in Ankara Branch. Lead and cadmium analysis was carried out by Graphite Furnace Atomic Spectrometry technique. Cd/Pb results and individuals' information were assessed by SPSS statistically. Average value of Pb was found as 1374.99±237.01ppb and Cd was found as 287.54±66.43ppb in all heart tissue samples. Consideration of metal levels in autopsy heart tissues by age, statistically significant positive correlation in Cd was observed (p<0.05). There was no correlation found between metal levels with gender and BMI values. Both Pb and Cd levels of the samples who lived in urban was significantly greater than in suburban areas (p<0.05). Significant increase Cd level were observed in smokers' heart tissues (p<0.05), however, contrary to expectations, Pb has no statistically significant result.

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“…Supporting data also exist in humans. Women with high levels of B‐Cd (>5μg/L vs. <5μg/L) showed a clear indication of oxidative stress in terms of increased plasma levels of malondialdehyde [68]. In a population study, U‐Cd was associated with the same and other markers of oxidative stress [69].…”

Section: Part Ii: Cadmium and Ascvd: Underlying Mechanismsmentioning

confidence: 99%