Endothelial Dysfunction in HIV

High Levels of von Willebrand Factor and Low Levels of its Cleaving Protease, ADAMTS13, are Associated with Stroke in Young HIV-Infected Patients

“…At a certain critical prothrombotic level, this may precipitate strokes in susceptible individuals. Endothelial dysfunction is an important feature of HIV infection and becomes more severe in advanced HIV where it is associated with increased cardiovascular risk (11). VWF is released by platelets and endothelial cells.…”