Endothelial Dysfunction During Pregnancy: Prediction of the Child Morbidity

Abstract

Aim of the study to evaluate the impact of the maternal endothelial dysfunction during the first trimester of pregnancy on the health state of her infant. Material and methods. The study included 163 babies delivered by 163 pregnant women. In all pregnant women, during the first trimester of the pregnancy, the endothelial dysfunction was assessed by means of cytometric examination of desquamated endothelial cells in the peripheral blood. There were studied the somatic health state of pregnant women and their 163 babies during the first year of life. Results. In groups of children from mothers with detected endotheliopathy by a decrease in the average diameter of desquamated endothelial cells in the first trimester of pregnancy there were observed significantly more frequently encountered disorders of the central nervous system, a higher rate of psychomotor retardation. In babies from such mothers there were also often diagnosed infectious-inflammatory diseases in the first year of life and significantly increased the incidence of iron deficiency anemia. Discussion. Endothelial dysfunction at early pregnancy causes the impaired formation of the uterine-fetal relationship, which is reflected in the formation of organ systems of the fetus, and leads to the development of neonatal and pediatric pathology. Conclusion. Indices of desquamated endothelial cells in the peripheral blood of the mother during the first trimester of pregnancy correlate with the somatic health of the newborn that can be applied in the practice of medicine as an informative test for early diagnosis of neonatal and infant morbidity.