Endothelial dysfunction and restenosis following percutaneous coronary intervention

Thanyasiri, Panuratn; Kathir, Krishna; Celermajer, David S.; Adams, Mark

doi:10.1016/j.ijcard.2006.08.015

Cited by 29 publications

(23 citation statements)

References 23 publications

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“…Nitric oxide inhibits vascular smooth muscle cell proliferation and prevents neointimal hyperplasia. Thanyasiri et al (4) showed that endotheliumdependent coronary artery dilatation was reduced in subjects with restenosis after percutaneous coronary intervention. It has also been shown that the NO prevents the development of restenosis after percutaneous transluminal coronary angioplasty (PTCA) by inhibiting the formation of mitogenic substances resulted from injured endothelial tissue and the adhesion of leukocyte and thrombocytes (5,6).…”

Section: Introductionmentioning

confidence: 99%

Could plasma asymmetric dimethylarginine level be a novel predictor beyond the classic predictors of stent restenosis?

Bal¹,

Yı́ldı́rı́r²,

Aydınalp³

et al. 2014

Anadolu Kardiyol Derg

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Objective: The aim of this study was to investigate the factors associated with coronary stent restenosis and if there is an association between plasma asymmetric dimethylarginine (ADMA) levels and stent restenosis. Methods: Ninety-one patients, who had a history of coronary bare metal stent implantation due to any cause in the last one year period, were admitted to this observational cross-sectional study. Coronary angiography was performed to all patients and quantitative angiography was used to determine the presence of stent restenosis. Laboratory parameters and angiographic features that contribute to stent restenosis were evaluated. Plasma ADMA levels were measured by using high performance liquid chromatography. Logistic regression analysis was used to determine the independent factors of stent restenosis. Results: Angiographic restenosis was found in 35 patients (38.5%). Stent diameter (p=0.038) and left ventricular ejection fraction (p=0.023) were lower and stent implantation history due to acute coronary syndrome (p=0.029), plasma ADMA level (5.0±1.8x10 -4 mmol/L vs. 3.9±1.0x10 -4 mmol/L, p=0.001), C-reactive protein concentration (p=0.016), white blood cell count (p=0.044) and stent length (p=0.005) were higher in patients with restenosis. Plasma ADMA level (β=0.536; OR: 1.710; CI: 1.022-2.861; p=0.041), C-reactive protein concentration (β=0.062; OR: 1.064; CI: 1.003-1.129; p=0.041), stent diameter (β=-3.047; OR: 0.048; CI: 0.007-0.313; p=0.002) and length (β=0.165; OR: 1.179; CI: 1.036-1.343; p=0.013) were found to be the independent predictors of stent restenosis in logistic regression analysis. Conclusion: We conclude that plasma ADMA levels may be used as a novel marker for stent restenosis beyond the classic stent restenosis markers. (Anadolu Kardiyol Derg 2014; 14: 491-7)

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Section: Introductionmentioning

confidence: 99%

Could plasma asymmetric dimethylarginine level be a novel predictor beyond the classic predictors of stent restenosis?

Bal¹,

Yı́ldı́rı́r²,

Aydınalp³

et al. 2014

Anadolu Kardiyol Derg

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show abstract

“…20,21 ). Previous reports showed an association between ISR and vasodilator dysfunction in forearm resistance vessels 18,21,22 , and several small studies have reported an association between ISR and increased plasma ADMA levels 17,18,20 . In contrast to the previous studies, we did not find a link between increased ADMA and the risk of ISR.…”

Section: Matrix Metalloproteinases (Mmps) Comprise a Family Of Zinc-dmentioning

confidence: 97%

Increased levels of MMP-3, MMP-9 and MPO represent predictors of in-stent restenosis, while increased levels of ADMA, LCAT, ApoE and ApoD predict bare metal stent patency

Pleva¹,

Kušnierová²,

Plevová³

et al. 2015

BIOMED PAP

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Aims. We sought to identify biochemical predictors that indicate susceptibility to in-stent restenosis (ISR) after coronary artery bare-metal stenting. Methods. A total of 111 consecutive patients with post-percutaneous coronary intervention (PCI) in-stent restenosis of a target lesion within 12 months were matched for age, sex, vessel diameter, and diabetes with 111 controls without post-PCI ISR. Plasma or serum levels of biochemical markers were measured: matrix metalloproteinases (MMP) 2, 3, 9; myeloperoxidase (MPO); asymmetric dimethylarginine (ADMA); lipoprotein (a) (Lp[a]); apolipoproteins E and D (ApoE and D); and lecitin-cholesterol acyltransferase (LCAT). Multivariable logistic regression association tests were performed. Results. Increased plasma MMP-3 (OR: 1.013; 95% CI: 1.004-1.023; P = 0.005), MMP-9 (OR: 1.014; 95% CI: 1.008-1.020; P < 0.0001) or MPO (OR: 1,003; 95% CI: 1.001-1.005; P = 0.002) was significantly associated with increased risk of ISR. Increased levels of ADMA (OR: 0.212; 95% CI: 0.054-0.827; P = 0.026), ApoE (OR: 0.924; 95% CI: 0.899-0.951; P < 0.0001), ApoD (OR: 0.919; 95% CI: 0.880-0.959; P = 0.0001), or LCAT (OR: 0.927; 95% CI: 0.902-0.952; P < 0.0001) was associated with risk reduction. No correlation was found between plasma MMP-2 or Lp (a) and ISR risk. Conclusions. Increased levels of MMP-3, MMP-9, and MPO represent predictors of ISR after bare-metal stent implantation. In contrast, increased ADMA, LCAT, and Apo E and D indicate a decreased in-stent restenosis occurrence.

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“…Despite that, the presence of intimal regeneration does not necessarily mean in stent endothelial recovery of function. In fact, in stent atherosclerosis and restenosis processes are strongly associated with impaired endothelial function [7]. Furthermore, in iliac artery rabbit study, Joner et al [8] found that, despite varying degrees of endothelial coverage, the staining of thrombomodulin, a physiologically relevant regulator of platelets and coagulation, was absent or only weakly expressed in 14-and 28-day DES, and was even reduced in BMS control stents compared with non-stented segments.…”

Section: Introductionmentioning

confidence: 99%

A Case of Very Late Bare-Metal Coronary Stent Thrombosis Two Weeks after Aspirin Discontinuation, Histopathologic Thrombus Findings and Clinical Considerations

Tanzilli¹,

Viceconte²,

Truscelli³

et al. 2017

J Clin Exp Cardiolog

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There have been consistent evidences that atherosclerotic changes occur inside bare metal stents (BMS) during an extended period after implantation. This report describes the histopathologic features of aspirated material harvested from a patient with definite very late stent thrombosis of a BMS implanted 18 years prior. The patient presented with a recurrent anterior acute myocardial infarction 14 day after aspirin discontinuation. We suggest that vulnerable neointimal tissue inside the stent struts of BMS may be one potential trigger of thrombosis when the protection of aspirin treatment is ceased.

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Endothelial dysfunction and restenosis following percutaneous coronary intervention

Cited by 29 publications

References 23 publications

Could plasma asymmetric dimethylarginine level be a novel predictor beyond the classic predictors of stent restenosis?

Could plasma asymmetric dimethylarginine level be a novel predictor beyond the classic predictors of stent restenosis?

Increased levels of MMP-3, MMP-9 and MPO represent predictors of in-stent restenosis, while increased levels of ADMA, LCAT, ApoE and ApoD predict bare metal stent patency

A Case of Very Late Bare-Metal Coronary Stent Thrombosis Two Weeks after Aspirin Discontinuation, Histopathologic Thrombus Findings and Clinical Considerations

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