Endothelial dysfunction and oxidative stress in children with sleep disordered breathing: Role of NADPH oxidase

Loffredo, Lorenzo; Zicari, Anna Maria; Occasi, Francesca; Perri, Ludovica; Carnevale, Roberto; Angelico, Francesco; Ben, Maria Del; Martino, Francesco De; Nocella, Cristina; Savastano, Vincenzo; Marcelli, Azzurra Cesoni; Duse, Marzia

doi:10.1016/j.atherosclerosis.2015.03.024

Cited by 48 publications

(38 citation statements)

References 39 publications

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“…Increased levels of inflammation have been found in children with OSAS (11), linking cardiovascular pathologies with secondary oxidative stress and intermittent hypoxia (12).…”

Section: Introductionmentioning

confidence: 99%

Indoor/outdoor not-voluptuary-habit pollution and sleep-disordered breathing in children: a systematic review

et al. 2017

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Background: Exposure to environmental pollutants is advocated to be a major risk factor, with increased morbidity and mortality in humans due to acute and chronic airway inflammation. The aim of the present review is to show the literature research regarding the link between the sleep-disordered breathing and exposure to indoor/outdoor pollution in children. We hypothesized that environmental air pollution can play a role in childhood sleep-disordered breathing. Methods:We conducted an electronic search in Medline (with PubMed interface), Scopus and the ISI Web of Science using the keywords "sleep" or "sleep apnea" or "sleep disordered breathing" and "pollution" and "children" in "Title/Abstract/Keywords", with language restriction (non-English paper) and no date limitation to present. The tobacco smoke pollution is well established linking and is not considered for the present subject. We examined the strength of the evidence according to the Oxford Centre for Evidence- Results: A total of 105 articles were identified, but 97 of these had to be excluded after an accurate reading of the title, abstract or full text. In the end, eight studies were selected for our analysis for a total of a total of 5,826 children. The results suggest an involvement (grade C) of environmental (not from voluptuary habits) pollution in the worsening of sleep-disordered breathing in children.Conclusions: To date, some studies reported significant differences between areas with higher and lower pollutants and the interventions on indoor pollution reduced sleep-disordered breathing in children.Therefore, although the relevance of the argument is high, the number of studies and the interest in the subject seems at this time quite limited.

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“…Increased levels of inflammation have been found in children with OSAS (11), linking cardiovascular pathologies with secondary oxidative stress and intermittent hypoxia (12).…”

Section: Introductionmentioning

confidence: 99%

Indoor/outdoor not-voluptuary-habit pollution and sleep-disordered breathing in children: a systematic review

et al. 2017

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“…Oxidized fatty acids and lysophosphatidylcholine stimulate expression of adhesion molecules and inflammatory cytokines by endothelial cells, promoting the adhesion and migration monocytes/macrophages to the subendothelial space where they become activated and transform into foam cell macrophages . Evidence for some of these events has been previously reported in pediatric OSA, further attesting to the systemic and widespread impact of the disease on the vasculature . Furthermore, Lp‐PLA2 activity can also directly decrease the ability of the endothelium to generate nitric oxide .…”

Section: Discussionmentioning

confidence: 72%

Endothelial Dysfunction in Children With Obstructive Sleep Apnea Is Associated With Elevated Lipoprotein‐Associated Phospholipase A2 Plasma Activity Levels

Kheirandish‐Gozal

Philby

Qiao

et al. 2017

JAHA

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Background--Obstructive sleep apnea (OSA) is a highly prevalent condition, especially in obese children, and has been associated with increased risk for endothelial dysfunction and dislipidemia, which are precursors of atherosclerosis. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is recognized as an independent risk factor for cardiovascular risk and atheromatous plaque activity. We hypothesized that Lp-PLA2 levels would be elevated in children with OSA, particularly among obese children who also manifest evidence of endothelial dysfunction.

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“…Endothelial dysfunction represents one of the major and early determinants for the development of atherosclerosis and its complications [2]. FMD is a first-line noninvasive method to assess endothelial function in different cardiovascular diseases [4][5][6]. Nevertheless, we agree with Balta and colleagues that FMD is a technique that needs further standardization before being routinely used in clinical practice.…”

Section: Dear Editormentioning

confidence: 68%

Reply to “The relation between flow mediated dilation and atrial fibrillation” by S. Balta

Perri

Pastori

Pignatelli

et al. 2015

International Journal of Cardiology

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Endothelial dysfunction and oxidative stress in children with sleep disordered breathing: Role of NADPH oxidase

Cited by 48 publications

References 39 publications

Indoor/outdoor not-voluptuary-habit pollution and sleep-disordered breathing in children: a systematic review

Indoor/outdoor not-voluptuary-habit pollution and sleep-disordered breathing in children: a systematic review

Endothelial Dysfunction in Children With Obstructive Sleep Apnea Is Associated With Elevated Lipoprotein‐Associated Phospholipase A2 Plasma Activity Levels

Reply to “The relation between flow mediated dilation and atrial fibrillation” by S. Balta

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