Endothelial Dysfunction and Microvascular Complications in Type 1 Diabetes Mellitus

Jin, Seon Mi; Noh, Chung Il; Yang, Sei Won; Bae, Eun Jung; Shin, Choong Ho; Chung, Hae Rim; Kim, You Yeh; Yun, Yong Soo

doi:10.3346/jkms.2008.23.1.77

Cited by 40 publications

(31 citation statements)

References 37 publications

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“…In the study of Jin and cols., forty-eight patients with T1DM and twenty two healthy individuals were compared in regard to FMD and intima carotid thickness. FMD was found significantly lower in diabetics, supporting our results (22). Lekakis and cols.…”

Section: Biochemical and Clinic Markers Of Ed In T1dmsupporting

confidence: 82%

Evaluation of biochemical and clinical markers of endothelial dysfunction and their correlation with urinary albumin excretion in patients with type 1 diabetes mellitus

Polat

Uğurlu

Aslan

et al. 2016

Arch. Endocrinol. Metab.

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Objective: Endothelial dysfunction (ED) plays an important role in the pathogenesis of diabetic nephropathy. The purpose of the study was to determine flow mediated endothelial dependent vasodilatation (FMD) measurements and serum soluble (s) endothelin-1 (ET-1), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) levels in patients with type 1 diabetes mellitus (T1DM) with or without increased urinary albumin excretion (UAE) and compare them with the healthy controls. Subjects and methods: Seventy three patients with T1DM were enrolled. Patients were divided into two subgroups according to microalbumin measurements in 24-hr urine collections. The diabetic patients without microalbuminuria (41 patients) were defined as Group I and those with microalbuminuria (32 patients) were defined as group II. A hundred age and sex matched healthy subjects participated as the control group (Group III). Serum sET-1, sICAM-1, sVCAM-1 levels and FMD measurements were determined in all participants. Results: Median FMD measurement was significantly lower in the diabetic groups compared with the control group (6.6, 6.4 and 7.8% in Group I, II and III, respectively) (p < 0.05). FMD was negatively correlated with age (p = 0.042). Median serum sICAM-1 level was higher in the patient groups compared to the control group (p < 0.05). Median serum sVCAM-1 level was higher in the group of patients with increased albuminuria compared to the normoalbuinuric and the control group (p < 0.05). Serum sVCAM-1 level was found to be positively correlated with degree of urinary albumin excretion (p < 0.001). Conclusion: We assume that sVCAM-1 may be used as a predictive marker for risk stratification for nephropathy development and progression. Arch Endocrinol Metab. 2016;60(2):117-24

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Section: Biochemical and Clinic Markers Of Ed In T1dmsupporting

confidence: 82%

Evaluation of biochemical and clinical markers of endothelial dysfunction and their correlation with urinary albumin excretion in patients with type 1 diabetes mellitus

Polat

Uğurlu

Aslan

et al. 2016

Arch. Endocrinol. Metab.

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“…There are some studies, not only in adults but also in children, which have previously demonstrated endothelial dysfunction using FMD evaluation with lower percentages of dilatation in T1D subjects in comparison with controls. [19][20][21][22][23][24] In addition, our paper is not the first to demonstrate a higher mean cIMT in subjects with T1D compared with a control group. 25,26 In a very recent paper, Sibal et al 27 showed impaired endothelial function (45% reduced) and increased cIMT in young people with T1D without macrovascular disease or microalbuminuria, but including 62% of subjects with retinopathy, 24% of smokers and a moderately poor average metabolic control (average HbA 1c of 8.5%).…”

Section: Discussioncontrasting

confidence: 63%

Preclinical arterial disease in patients with type 1 diabetes without other major cardiovascular risk factors or micro-/ macrovascular disease

Giménez

Gilabert

Lara

et al. 2010

Diabetes and Vascular Disease Research

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We aimed to investigate preclinical atherosclerosis in T1D and its relationship with glucose profile and endothelial/ inflammatory markers. Thirty-eight T1D patients without additional cardiovascular risk factors or micro-/macrovascular complications and 22 healthy matched subjects were included. FMD and cIMT/fIMT were performed in addition to 72-h continuous glucose monitoring and the measurement of endothelial/inflammatory markers. Lower FMD percentages and greater cIMT/fIMT were observed in patients with T1D in comparison with controls (FMD 7.0±3.1% vs. 9.6±2.2%; p<0.005; cIMT 0.523±0.091 mm vs. 0.471±0.061 mm; p<0.05 and fIMT 0.512±0.172mm vs. 0.394±0.061mm; p<0.01, for patients and controls, respectively). T1D subjects in the highest tertile of cIMT were older than those in the lowest group (39.9±9.5 vs. 29.6±4.7 years; p<0.005) and had a longer duration of the disease (18.7±5.4 years vs. 11.8±6.4 years). The higher the cIMT tertile, the greater the fIMT (0.397±0.114 mm vs. 0.431±0.082 mm vs. 0.583±0.197 mm; p<0.05). MAGE was negatively correlated to FMD (r=-0.328; p<0.05) and positively to cIMT (r=0.322; p<0.05). There were no differences between cIMT tertiles in terms of metabolic parameters or endothelial and inflammatory markers. Signals of preclinical atherosclerosis in T1D even in the absence of cardiovascular risk factors and micro-/ macrovascular disease are reported. Our findings suggest that daily glucose instability could negatively impact vascular function and structure.

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“…Low percentage of FMD was also found in patients with rheumatoid arthritis because 62 of chronic inflammation (17-18). Jin et al (19) found that FMD percentages were lower in patients with diabetes mellitus (DM) than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Relationship between endothelial dysfunction and microalbuminuria in familial Mediterranean fever

et al. 2016

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Objective: The aim of our study is to investigate the relationship between microalbuminuria and flow-mediated dilatation in familial Mediterranean fever (FMF) patients.Material and Methods: In our study, there were two groups consisting of 54 patients who were out of the attack period (43 of whom had no microalbuminuria and 11 of whom had microalbuminuria) and 40 healthy controls (M/F: 12/28).Results: There was no statistically difference between patient and control groups'age (25.06±8.07, 22.89±6.00 years, respectively).Flow-mediated dilatation (FMD) percentages were significantly different between the three groups (p=0.01). It was observed that there was a correlation between microalbuminuria and FMD percentage. Conclusion:Endothelial dysfunction and renal damage occurred as a result of low-grade chronic inflammation. Microalbuminuria, which is the indicator of renal damage and endothelial dysfunction, and FMD show that endothelial functions can be used in the following of early detection of renal damage and endothelial functions in FMF patients.

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Endothelial Dysfunction and Microvascular Complications in Type 1 Diabetes Mellitus

Cited by 40 publications

References 37 publications

Evaluation of biochemical and clinical markers of endothelial dysfunction and their correlation with urinary albumin excretion in patients with type 1 diabetes mellitus

Evaluation of biochemical and clinical markers of endothelial dysfunction and their correlation with urinary albumin excretion in patients with type 1 diabetes mellitus

Preclinical arterial disease in patients with type 1 diabetes without other major cardiovascular risk factors or micro-/ macrovascular disease

Relationship between endothelial dysfunction and microalbuminuria in familial Mediterranean fever

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