Endothelial cells in dengue hemorrhagic fever

Abstract

Therapies to prevent or reverse endothelial dysfunction and vascular leak found in dengue hemorrhagic fever (DHF) have not been identified. In this review we summarize dengue viruses and the spectrum of human disease and highlight evidence of endothelial cell dysfunction in DHF based on studies in patients and mouse and tissue culture models. Evidence suggests that both virus antigen and host immune response, can cause endothelial cell dysfunction and weaken endothelial barrier integrity. We suggest possible therapeutic interventions and highlight how therapies targeting altered endothelial function might be evaluated in animal models and in patients with DHF.

Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care

“…Later, however, virus can also be detected in endothelia and might then contribute to vascular leak syndrome. 13 The endovascular permeability failure in vascular leak syndrome can lead to the loss of intravascular proteins such as coagulation factors, and cellular defi cits such as thrombocytopenia. 14 The shift of intravasal fl uids can cause fatal lung oedema and the need to ventilate the patient mechanically, often requiring high inspirational peak and positive end-expiratory pressures.…”

Reguladores de integridad endotelial como posibles predictores de la gravedad en casos de dengue

“…Sin embargo, la detección oportuna de quién va a desarrollar la fuga plasmática y cómo tratarla sigue siendo un reto (21).…”

Severe dengue in the early postoperative period after kidney transplantation: two case reports from Hospital Geral de Fortaleza

“…There is some evidence that changes in the complement system that culminate in the formation of immune complexes favor such events (5) . While changes in endothelial cells are studied most extensively, immune mediators of the adaptive response are produced chiefl y by T cells.…”