Endothelial and inducible nitric oxide synthases in oocytes of cattle

Pires, Pedro Ratto Lisboa; Santos, Nilton Pedro dos; Adona, Paulo Roberto; Natori, Mariene Miyoko; Schwarz, Kátia Regina Lancellotti; De, Tiago Henrique Camara; Leal, Cláudia Lima Verde

doi:10.1016/j.anireprosci.2009.02.019

Cited by 35 publications

(21 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As well as in porcine oocytes, nitric oxide synthases (NOS) were detected in bovine oocytes [38]. Oocyte maturation was noticeably inhibited by the use of NOS inhibitors [39], which strengthens the hypothesis that NO plays a role during oocyte meiosis in this model.…”

Section: No In Bovine Oocytes Eggs and Embryossupporting

confidence: 59%

From Nitric Oxide Toward S-Nitrosylation: Expanding Roles in Gametes and Embryos

Ješeta¹,

Sedmı́ková²,

Bodart³

2017

Nitric Oxide Synthase - Simple Enzyme-Complex Roles

View full text Add to dashboard Cite

Nitric oxide (NO) is a gasotransmitter involved in various aspects of reproduction. The observational data from different species, such as sea urchin, ascidians, amphibians, rodents, porcine, bovine, and human, suggest that NO might have a significant role in reproduction through several mechanisms. This proposed role might appear preserved through evolution; however, the effects of NO also depend on the species or stages considered. There has been debate over the physiological relevance of NO, though the benefits of its use in assisted reproduction are now widely recognized. Over the past years, S-nitrosylation has provided a new angle to decipher the mechanisms through which NO exerts its actions. This chapter summarizes, in a nonexhaustive manner, research that explores the role of NO in gametes and embryos.

show abstract

Section: No In Bovine Oocytes Eggs and Embryossupporting

confidence: 59%

From Nitric Oxide Toward S-Nitrosylation: Expanding Roles in Gametes and Embryos

Ješeta¹,

Sedmı́ková²,

Bodart³

2017

Nitric Oxide Synthase - Simple Enzyme-Complex Roles

View full text Add to dashboard Cite

show abstract

“…In fact, whereas eNOS mRNA was detected in both theca and granulosa cell layers, the protein was immunolocalized only in the theca, and exclusively in the blood vessels of developing preovulatory and postovulatory healthy follicles (Grazul-Bilska et al, 2006). As in sheep (Grazul-Bilska et al, 2007;Pires et al, 2009), in cows we found eNOS protein localized in endothelial cells of theca blood vessels. Moreover, we observed a greater eNOS protein expression in follicles from Hi ovaries when compared with follicles from Lo ovaries.…”

Section: Discussionmentioning

confidence: 67%

The endothelial nitric oxide synthase/nitric oxide system is involved in the defective quality of bovine oocytes from low mid-antral follicle count ovaries1

Tessaro

Luciano

Franciosi

et al. 2011

Journal of Animal Science

View full text Add to dashboard Cite

“…In a study on the effect of varying NO concentrations on bovine oocyte nuclear maturation, Bilodeau-Goeseels (2007) reported that germinal vesicle breakdown in cumulus-enclosed oocytes was prevented or stimulated by high or low doses of the NO donor SNP respectively. These observations would suggest that NO reduction, possibly linked to transcript reduction in eNOS, is necessary for germinal vesicle breakdown (Tesfaye et al 2006, Pires et al 2009) and meiosis resumption.…”

Section: No In Oocyte Competencementioning

confidence: 99%

“…eNOS and iNOS expression has been documented in mammalian oocytes (mice: Mitchell et al and their presence was confirmed throughout folliculogenesis and follicle maturation (Chmelíková 00000000000et al 2009, Pires et al 2009). As for nNOS, its presence in oocytes has been documented only in the pig (Chmelíková et al 2009), and its mRNA in the mouse (Abe et al 1999).…”

Section: No In Oocyte Competencementioning

confidence: 99%

“…In the bovine, Pires et al (2009) demonstrated that eNOS is detectable in theca, granulosa, surface epithelium, and corpus luteum, and that NO is necessary for follicle development. In addition, Moonmanee et al (2013) pointed out a relationship among eNOS expression, vascularization, and mitotic activity in the first follicular wave, thus suggesting a role for eNOS in selection of nonovulatory dominant follicles.…”

Section: Regulation Of No Productionmentioning

confidence: 99%

See 1 more Smart Citation

Nitric oxide in follicle development and oocyte competence

Basini

Grasselli

2015

Reproduction

View full text Add to dashboard Cite

Apart from its well-known role in regulating endothelial function, in mammals, nitric oxide (NO) is an important signaling molecule involved in many processes, regulating different biological functions. It has been demonstrated that NO plays a role in the physiology of the reproductive system, where it acts in controlling the activity of reproductive organs in both sexes. In the female of several animal species, experimental data suggest the presence of an intraovarian NO-generating system, which could be involved in the control of follicular development. The role of NO in regulating follicular atresia by apoptosis is still controversial, as a dual action depending mostly on its concentration has been documented. NO also displays positive effects on follicle development and selection related to angiogenic events and it could also play a modulatory role in steroidogenesis in ovarian cells. Both in monovulatory and poliovulatory species, the increase in PGE 2 production induced by NO via a stimulatory effect on COX-2 activity appears to be a common ovulatory mechanism. Considerable evidence also exists to support an involvement of the NO/NO synthase system in the control of meiotic maturation of cumulus-oocyte complexes.Reproduction (2015) 150 R1-R9

show abstract

Endothelial and inducible nitric oxide synthases in oocytes of cattle

Cited by 35 publications

References 48 publications

From Nitric Oxide Toward S-Nitrosylation: Expanding Roles in Gametes and Embryos

From Nitric Oxide Toward S-Nitrosylation: Expanding Roles in Gametes and Embryos

The endothelial nitric oxide synthase/nitric oxide system is involved in the defective quality of bovine oocytes from low mid-antral follicle count ovaries1

Nitric oxide in follicle development and oocyte competence

Contact Info

Product

Resources

About