Endothelial alterations in 712 keratoconus patients

Goebels, S.; Eppig, Timo; Seitz, Berthold; Szentmáry, Nóra; Cayless, Alan; Langenbucher, Achim

doi:10.1111/aos.13471

Cited by 25 publications

(31 citation statements)

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“…Previous studies have found that the corneal ECD and morphology are important factors affecting different stages of KCN. 24 , 25 We designed this study in order to evaluate and compare the morphology and characteristics of corneal endothelial cell in bilateral KCN patients with and without Vogt's striae using the Topcon SP2000P non-contact specular microscope.…”

Section: Discussionmentioning

confidence: 99%

“…argued that the presence of KCN did not affect the ECD, 18 while Goebels and colleagues emphasizes that as the severity of KCN increase, ECD decreases and CV increases. 24 Also, Timocin et al. conducted a research study to assess the ECD in keratoconic eyes and indicated that the change in ECD did not depend on the CCT and different stages of KCN.…”

Section: Discussionmentioning

confidence: 99%

“…Many articles have evaluated the corneal endothelial cell layer in KCN eyes, 24 , 25 , 26 but no study has assessed the corneal ECD and morphology in Vogt's striae using the specular microscopy. The aim of this contralateral eye study was to compare corneal endothelial cell properties measured with the Topcon SP2000P non-contact specular microscope in patients with bilateral KCN with unilateral Vogt's striae.…”

Section: Introductionmentioning

confidence: 99%

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A contralateral eye study comparing characteristics of corneal endothelial cells in bilateral keratoconus patients with unilateral corneal Vogt's striae

Ostadimoghaddam

Sedaghat

Rakhshandadi

et al. 2018

Journal of Current Ophthalmology

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PurposeThe aim of this study was to analyze and compare corneal endothelial cell morphology and characteristics in bilateral keratoconus (KCN) patients with unilateral Vogt's striae.MethodsFifty patients aged 20–38 years were recruited in this cross-sectional contralateral eye study. In this study, corneal endothelial cell parameters were evaluated in patients with bilateral KCN and unilateral Vogt's striae using the Topcon SP2000P specular microscope (Topcon, Tokyo, Japan).ResultsIn the current study, there were no significant differences in corneal endothelial cell parameters including endothelial cell density (ECD), hexagonal cell ratio (HEX), and coefficient of variance of cell size (CV) between the KCN groups with and without Vogt's striae, [(2968.34 ± 276.65 vs. 2980.05 ± 253.30, P = 0.618), (51.88 ± 13.57 vs. 53.24 ± 9.31, P = 0.658), and (32.50 ± 5.40 vs. 32.97 ± 4.07, P = 0.467), respectively]. Also, among study groups with and without Vogt's striae, ECD did not correlate with anterior chamber depth (ACD) [(P = 0.564, r = 0.09), (P = 0.219, r = −0.18), respectively], maximum keratometry (Kmax) [(P = 0.215, r = 0.18), (P = 0.898, r = 0.02), respectively], and central corneal thickness (CCT) [(P = 0.989, r = −0.02), (P = 0.643, r = −0.07), respectively].Our results showed significant differences in corrected and uncorrected distance visual acuity (UDVA), cycloplegic refractive error components (calculated by vectorial analysis), CCT, and Kmax between two study groups (all P < 0.05) except for J45 (Jackson cross cylinder, axes at 45 and 135°) (P = 0.131).ConclusionsWe were not able to find the statistically significant differences in ECD, HEX, and CV between KCN eyes with and without Vogt's striae. Despite clinical and tomographic results, it seems that Vogt's striae cannot cause deterioration in the corneal endothelial morphology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A contralateral eye study comparing characteristics of corneal endothelial cells in bilateral keratoconus patients with unilateral corneal Vogt's striae

Ostadimoghaddam

Sedaghat

Rakhshandadi

et al. 2018

Journal of Current Ophthalmology

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“…10 Goebels et al observed that ECD decreased and CV increased with the progression of keratoconus in their work containing 712 KC cases. 9 Our study comprised only those patients who had not undergone a surgical procedure previously and had no contact lens use history. When the participants were classi ed according to the KC stage, the number of patients in the severe stages was lower.…”

Section: Discussionmentioning

confidence: 99%

“…Some publications reported lower endothelial cell density (ECD) compared to healthy eyes, whereas others observed no signi cant change. [9][10][11][12] Similarly, several publications in the literature report a decrease in the hexagonal cell percentage (HCP) and an increase in the coe cient of variation (CV) in KC cases, while some studies report no change. [9][10][11][12] Reasons for the different results may be related to the number of patients included in the studies, the distribution of the age range of the patients, the stages of keratoconus, and the previous treatment approaches.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Corneal Endothelium in Middle-Aged Keratoconus Eyes

Dogan¹,

Çakır²,

Aksoy³

et al. 2021

Preprint

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Purpose To investigate the corneal endothelial cell parameters and to evaluate the correlation with corneal topographic parameters in middle-aged non-treated keratoconus (KC) patients. Materials and Methods Thirty-six eyes of 21 KC patients in the middle decade (4th-5th) and age-gender matched 36 healthy eyes were included. Topographic parameters [(K1, K2 Sim K, central, thinnest pachymetry, anterior chamber depth (ACD)] were obtained with Galillei double scheimpflug analyzer. Patients were divided into stages according to mean keratometric values (Mild < 45D,Moderate 45-52D, Severe > 52D, Advanced > 62 D). Endothelial cell density (ECD), coefficient of variation (CV) of cell areas and hexagonal cell percentage (HCP) obtained with specular microscopy were recorded.Corneal topography and specular microscopy parameters were compared between KC and healthy eyes. The correlation between topographic and specular microscopy parameters were analyzed. Results The mean age of the patients was 38.6 ± 6.0 and 37.8 ± 4.2 years in the KC and control group, respectively. Age and gender were statistically similar between the groups. ECD was 2772 ± 17 in the KC group and 2741 ± 30 cells / mm2 in the control group, and there was no statistical difference between the groups (p: 0.621). HCP was 63.5 ± 7.2, 67.4 ± 5.2 in KC and healthy eyes, respectively (p: 0.014); CV was 30.7 ± 5.2 and 28.6 ± 3.4, respectively (p: 0.058). Specular microscopy parameters were not statistically different according to KC stage. K1,K2,SimK, CCT, ACD did not correlate with ECD in patients. Conclusion Our results showed that endothelial cell morphology is significantly affected in middle-aged KC patients who have not been treated.

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