Endoscopically Guided Aerobic Cultures in Postsurgical Patients with Chronic Rhinosinusitis

Coffey, Charles S.; Sonnenburg, Robert E.; Melroy, Christopher T.; Dubin, Marc G.; Senior, Brent A.

doi:10.1177/194589240602000113

Cited by 32 publications

(34 citation statements)

References 16 publications

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“…This may be because CoNS is not only the most common bacterial isolate in CRS in general, but also in subgroups of CRS, such as patients with a history of FESS. 12-15 Thus, the associations between the clinical factors and CoNS groups did not differ depending on the presence of nasal polyps or history of prior FESS. Therefore, it is appropriate to report combined results in Tables 2 and 3.…”

Section: Discussionmentioning

confidence: 81%

“…Several published studies looked at the presence of bacteria in postoperative sinus using endoscopically directed cultures, 12-15 and found that CoNS was one of the most common bacterial isolates in postoperative CRS patients. 12-15 In our study, 106 patients had CoNS as the sole positive culture result and 111 patients had CoNS as part of polymicrobial isolation, and thus, CoNS was also the most common bacterial isolate. The novelty of our study is that we analyzed the group of CRS patients with CoNS as the sole positive culture result separately.…”

Section: Discussionmentioning

confidence: 99%

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Coagulase‐negative Staphylococcus culture in chronic rhinosinusitis

Zhang

Adappa

Lautenbach

et al. 2014

Int Forum Allergy Rhinol

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Objective Coagulase-negative staphylococcus (CoNS) is commonly isolated from patients with chronic rhinosinusitis (CRS). However, the role of CoNS in CRS remains controversial. We aimed to determine the associations between positive CoNS culture at functional endoscopic sinus surgery (FESS) and CRS severity. Methods Adult CRS patients who underwent FESS between 10/1/2007 to 12/31/2011 were recruited. Patient demographics, disease characteristics, medication use, Lund-Mackay CT scores, and SNOT-22 scores were collected at baseline before FESS. Intraoperative cultures were obtained in a standard manner. Patients were placed into two groups based on culture findings: patients with CoNS as the sole positive culture result and patients with all other positive culture results, including CoNS, as part of a polymicrobial culture. Results 376 CRS patients met the criteria. 106 patients (28%) had CoNS as their only isolate, 260 (69%) had other positive cultures, and 10 (3%) had no bacterial growth. Compared to patients with other positive cultures, patients with the sole result of CoNS were significantly less likely to have a history of FESS (52% versus 65%, p=0.019), nasal polyps (50% versus 65%, p=0.006), and had a better Lund-Mackay CT score (11.95 versus 14.18, p=0.020). After adjusting for all factors in the multiple logistic regression model, CoNS as the sole positive culture result was independently associated with having no history of FESS (OR=0.45, 95%CI, 0.22-0.94, p=0.034). Conclusion Positive intraoperative CoNS cultures alone do not result in increased CRS disease burden by objective or subjective measures as compared to patients with other bacterial or polymicrobial culture isolates.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Coagulase‐negative Staphylococcus culture in chronic rhinosinusitis

Zhang

Adappa

Lautenbach

et al. 2014

Int Forum Allergy Rhinol

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“…A few studies have looked at the presence of bacteria in postoperative sinus descriptively, and S. aureus and P. aeruginosa were the most common isolates. 9,31 However, the effects of positive culture of S. aureus and P. aeruginosa in CRS remain unclear, because 20% of healthy subjects have persistent nasal carriage of S. aureus, and 60% have intermittent carriage. 32 Our study suggests that S. aureus and P. aeruginosa in CRS may be associated with different comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Different clinical factors associated with Staphylococcus aureus and Pseudomonas aeruginosa in chronic rhinosinusitis

Zhang

Adappa

Doghramji

et al. 2015

Int Forum Allergy Rhinol

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“…Finally, bacterial and fungal cultures of nasal mucous secretions did reveal the presence of bacteria ( Pseudomonas and Acinetobacter ) as well as fungi ( Penicillium and Aspergillus ). Thus both patients had severe chronic rhinosinusitis most likely related to microbes (bacteria and fungi) detected in their water-damaged home [1–3, 5, 6, 23–25]. …”

Section: Ent Evaluationmentioning

confidence: 99%

A Water-Damaged Home and Health of Occupants: A Case Study

Thrasher¹,

Gray²,

Kilburn

et al. 2012

Journal of Environmental and Public Health

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A family of five and pet dog who rented a water-damaged home and developed multiple health problems. The home was analyzed for species of mold and bacteria. The diagnostics included MRI for chronic sinusitis with ENT and sinus surgery, and neurological testing for neurocognitive deficits. Bulk samples from the home, tissue from the sinuses, urine, nasal secretions, placenta, umbilical cord, and breast milk were tested for the presence of trichothecenes, aflatoxins, and Ochratoxin A. The family had the following diagnosed conditions: chronic sinusitis, neurological deficits, coughing with wheeze, nose bleeds, and fatigue among other symptoms. An infant was born with a total body flare, developed multiple Cafe-au-Lait pigmented skin spots and diagnoses with NF1 at age 2. The mycotoxins were detected in bulk samples, urine and nasal secretions, breast milk, placenta, and umbilical cord. Pseudomonas aueroginosa, Acinetobacter, Penicillium, and Aspergillus fumigatus were cultured from nasal secretions (father and daughter). RT-PCR revealed A. fumigatus DNA in sinus tissues of the daughter. The dog had 72 skin lesions (sebaceous glands and lipomas) from which trichothecenes and ochratoxin A. were detected. The health of the family is discussed in relation to the most recent published literature regarding microbial contamination and toxic by-products present in water-damaged buildings.

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Endoscopically Guided Aerobic Cultures in Postsurgical Patients with Chronic Rhinosinusitis

Cited by 32 publications

References 16 publications

Coagulase‐negative Staphylococcus culture in chronic rhinosinusitis

Coagulase‐negative Staphylococcus culture in chronic rhinosinusitis

Different clinical factors associated with Staphylococcus aureus and Pseudomonas aeruginosa in chronic rhinosinusitis

A Water-Damaged Home and Health of Occupants: A Case Study

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