Endoscopic Ultrasonography for Preoperative Diagnosis and Localization of Insulinomas

Nesje, L. B.; Varhaug, Jan Erik; Husebye, E. S.; Ødegaard, Svein

doi:10.1080/00365520212501

Cited by 19 publications

(9 citation statements)

References 26 publications

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“…In a study performed on 30 patients by Fendrich et al, the overall sensitivity reported for EUS, was 86.6%, compared to 33.0% for CT and 40.0% for MRI [8]. In another study, sensitivity of the localization procedure was as follows: US: 9.6%, CT: 39.0%, EUS: 92.3% [9]. In our study, spiral CT and US only detected one patient with insulinoma.…”

Section: Discussioncontrasting

confidence: 58%

Endoscopic ultrasonography (EUS) in the localization of insulinoma

Sotoudehmanesh

Abbastabar

Shirazian

et al. 2007

Endocr

130

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Section: Discussioncontrasting

confidence: 58%

Endoscopic ultrasonography (EUS) in the localization of insulinoma

Sotoudehmanesh

Abbastabar

Shirazian

et al. 2007

Endocr

130

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“…Die Verdachtsdiagnose wurde bei allen Patienten durch einen Hungerversuch bestätigt. Ergebnisse: Im Beobachtungszeitraum wurden 40 Patienten (22 Frauen,18 Männer) mit einem mittleren Alter von 52 Jahren (Spannbreite 12-87 Jahre) wegen eines Insulinoms operiert. In der präoperativen Lokalisationsdiagnostik betrugen die Sensitivitäten von Endosonographie (EUS), Sonographie (US), Computertomographie (CT), Kernspintomographie (MRT) und Somatostatin-Rezeptor-Szintigraphie (SRS) 65%, 33%, 33%, 15% und 0%.…”

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Diagnostik und operative Therapie beim Insulinom - Erfahrungen bei 40 Patienten

Fendrich

Bartsch²,

Langer³

et al. 2004

Dtsch med Wochenschr

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“…However, only low sensitivities have been shown in different studies (4)(5)(6)(7)(8)14). EUS imaging has been shown to be very effective for the preoperative localization of insulinomas and has been suggested as first-line investigation (4,(15)(16)(17). The largest cohort published (7) refers to 40 patients and comes to the worst results available in the literature, with correct localization in 65%.…”

Section: Discussionmentioning

confidence: 99%

Preoperative diagnosis of insulinoma: low body mass index, young age, and female gender are associated with negative imaging by endoscopic ultrasound

Kann¹,

Ivan²,

Pfützner³

et al. 2007

eur j endocrinol

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Objective: Endoscopic ultrasound (EUS) is a highly reliable procedure to localize insulinomas preoperatively. It has been considered to be important in planning surgical strategy, especially considering a minimal invasive approach. However, even under ideal conditions experienced examiners miss about 10-20% of insulinomas by EUS imaging. Design and methods: This retrospective study aimed to identify factors associated with negative EUS imaging. Twenty-nine consecutive patients (24 benign and 5 malignant) with sporadic pancreatic insulinomas confirmed by successful surgery and positive histopathology were included. All EUS examinations were performed by one single experienced examiner over a period of one decade. Results: Three of the tumors were not detected by preoperative EUS as they were isoechoic to the surrounding healthy pancreatic tissue; 25 could be detected as hypoechoic lesions, (including all malignant tumors), and one lesion was hyperechoic. Low body mass index (PZ0.053) and young age (PZ0.037) were associated with negative EUS imaging. All patients with negative imaging were females. The position on the examiner's learning curve, the diameter and location of insulinoma, and endocrine parameters (insulin concentrations and insulin-glucose ratios in the prolonged fasting test) had no influence on the success of EUS imaging. Conclusions: Some insulinomas are missed by preoperative EUS imaging as they are completely isoechoic. A low body mass index, female gender, and young age might be risk factors for negative imaging.

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Endoscopic Ultrasonography for Preoperative Diagnosis and Localization of Insulinomas

Abstract: Our experience with seven insulinomas accords with previous reports claiming EUS to be the method of choice for preoperative imaging and localization of pancreatic islet cell tumors.

Cited by 19 publications

References 26 publications

Endoscopic ultrasonography (EUS) in the localization of insulinoma

Endoscopic ultrasonography (EUS) in the localization of insulinoma

Diagnostik und operative Therapie beim Insulinom - Erfahrungen bei 40 Patienten

Preoperative diagnosis of insulinoma: low body mass index, young age, and female gender are associated with negative imaging by endoscopic ultrasound

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