Endoscopic ultrasonography and computed tomography scanning for preoperative staging of colonic cancer

Malmstrøm, Marie Louise; Gögenur, Ismail; Lb, Riis; Hassan, Hazem; Klausen, TW; Perner, Trine; Săftoiu, Adrian; Vilmann, Peter

doi:10.1007/s00384-017-2820-x

Cited by 9 publications

(6 citation statements)

References 29 publications

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“…The current study describes the EUS T stage accuracy by using two different judgment methods and paying attention to distinguish T3 from T4a T stage. The key findings of this paper are the following: (1) The relationship between the lesions and the seminal vesicles or cervix visualized by EUS might be a predictive factor for distinguishing T3 fromT4a stage; (2) When the lesions are located above the seminal vesicles or cervix, there is a difference between the anterior (T4a) and posterior (T3) walls of the rectum; (3) Rectal wall outer edge irregularity, the tumor location, and histological type were associated with accuracy; (4) The EUS image features of each tumor T stage could guide judgment for EUS gastroenterologist.…”

Section: Discussionmentioning

confidence: 90%

“…For this prospective study, patients were included if the distal margin of the tumor was within 15 cm from the anal verge (14). In order to assess EUS accuracy: (1) We first used previously published method (15,16), dividing tumor site into low, middle, or upper based on the distance of the tumor margin to the anus: upper third from 12 to 15 cm, middle third from 8 to 12 cm, and lower third from 7 cm to the anus; (2) Then, we used the new evaluation criterion. With special attention to the location of seminal vesicles and tumor during EUS: for T1 and T2 stage, the method is the same as published.…”

Section: Methods For Evaluation Of Colorectal Cancer T Staging By Eusmentioning

confidence: 99%

“…In many studies involving colorectal cancer, the accuracy of EUS for T staging ranged from 70 to 93%, compared with 65 to 75% for computed tomography, and 75 to 85% for magnetic resonance imaging. EUS is indeed considered as the first-choice imaging modality for regional staging of colorectal cancer compared to other methods (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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How Useful Is Endoscopic Ultrasound in Differentiating T3/T4a T Stage of Colorectal Cancer: A Prospective Study

et al. 2022

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ObjectiveEndoscopic ultrasound (EUS) is an established method for staging of colorectal cancer. Nevertheless, prior assessments of its T stage accuracy have been limited, particularly ambiguity in assessed T3 and T4a stage. This study was to characterize the EUS image features and pay attention to distinguish T3 from T4a T stage.MethodsA total of 638 patients who prospectively underwent colorectal EUS were recorded. The final diagnoses were compared with the concurrent or follow-up histopathology. Univariate and multivariate logistic regressions were used to assess variation in diagnostic performance with case attributes.ResultsThe accuracies of EUS in classifying colorectal cancer for overall, T1, T2, T3, and T4a stages are 73.04, 62.32, 67.46, 71.26, and 83.52%, respectively. With attention to EUS image features, the lesion penetrates the entire wall and locates below the seminal vesicles or cervix is T3 stage. If the lesion locates above clearly-defined space between the anterior rectal wall and the posterior surface of the seminal vesicles or cervix, we identify as T4a stage; However, when located above seminal vesicles or cervix but on the posterior wall of the rectum, the lesion still considers as T3 stage. The tumor location and histological type are associated with inaccuracy T stage.ConclusionsEUS provides reliable diagnostic accuracy in the colorectal cancer stage. The seminal vesicles and cervix are the important markers to predict infiltration depth for T3/T4a stage. Furthermore, the tumor location, histological type, and EUS image features for each tumor T stage should warrant attention.

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Section: Discussionmentioning

confidence: 90%

Section: Methods For Evaluation Of Colorectal Cancer T Staging By Eusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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How Useful Is Endoscopic Ultrasound in Differentiating T3/T4a T Stage of Colorectal Cancer: A Prospective Study

et al. 2022

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“…With the advantages of non-invasive nature, simple operation, clear images and high resolutions, CT scan is effective in the diagnosis of colon cancer. CT scan can be completed in one breath; Thus, this technique has been widely used in clinical practices ( 17 ). Diagnostic value of CT is mainly reflected by its morphological information.…”

Section: Discussionmentioning

confidence: 99%

Relationship between CT signs and the expression of miR‑146a in colon cancer

Liu

Luo

2018

Oncol Lett

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Our study investigated the relationship between CT signs of colon cancer and the expression of miR-146a, to evaluate their predictive value in early diagnosis and of colon cancer. A total of 216 patients with colon cancer who were admitted to the Department of Hematology and Oncology in Yingcheng Hospital, the Second Hospital of Shandong University in Zhaoyuan City from January 2013 to March 2017 were selected as the study group. At the same time, 150 patients with benign colitis were also included to serve as the control group. CT scan was performed for patients in both the study and control groups. The expression of miR-146a in serum of patients in the study and control groups was detected by RT-qPCR, and of CT signs and miR-146a expression were analyzed. The relative expression level of miR-146a in peripheral blood of study group was significantly lower than that of the control group (t=12.180, p=0.001). Sensitivity and specificity of combined detection of CT and miR-146a in the study and control groups were 91.4 and 93.6%, respectively, which were higher than those of the single test (p<0.05). Among CT signs of study group, luminal wall, cavity and diameter changes, as well as size of tumor and surrounding tissues showed no significant correlation with the expression of miR-146a (p>0.05). The expression level of miR-146a in patients with high-risk of invasion was significantly higher than that in patients with low-risk of invasion (t=4.791, p=0.001). The expression level of miR-146a in lymph node metastasis was significantly lower than that in non-lymph node metastasis (t=3.104, p=0.002). miR-146a may be involved in the development and progression of colon cancer. Combined detection of CT and miR-146a may enhance the sensitivity and specificity of the diagnosis of colon cancer, and may provide a good predictive value for invasion and metastasis of colon cancer.

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“…Применение данного метода в стадировании РОК исследуется. При сравнении EUS и КТ специфичность по отношению к опухолям высокого риска была выше в группе EUS [15].…”

Section: стадирование и возможности диагностикиunclassified

Perioperative chemotherapy in the treatment of locally advanced forms of colon cancer: literature review

Шабунин

Греков

Bagateliya

et al. 2022

Onkol. koloproktol.

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Неоадъювантная химиотерапия является стандартом лечения многих опухолей, в особенности желудочно-кишечного тракта. Данный подход имеет много потенциальных преимуществ, включая регресс опухоли, раннее начало лечения микрометастазов, а также возможность оценивать биологию опухоли, тем самым персонализируя подход к лечению. В настоящее время неоадъювантная химиотерапия не является стандартом лечения местно-распространенного рака ободочной кишки, что связано с неточностью предоперационного стадирования, возможностью прогрессирования опухоли, а также отсутствием достаточного количества рандомизированных клинических исследований.

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Endoscopic ultrasonography and computed tomography scanning for preoperative staging of colonic cancer

Abstract: NCT02324023.

Cited by 9 publications

References 29 publications

How Useful Is Endoscopic Ultrasound in Differentiating T3/T4a T Stage of Colorectal Cancer: A Prospective Study

How Useful Is Endoscopic Ultrasound in Differentiating T3/T4a T Stage of Colorectal Cancer: A Prospective Study

Relationship between CT signs and the expression of miR‑146a in colon cancer

Perioperative chemotherapy in the treatment of locally advanced forms of colon cancer: literature review

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