“…[1][2][3][4][5][6][7][8] Numerous modifications have been developed to promote ostial patency, ranging from various methods of producing the nasal mucosal and/or lacrimal sac flaps, 2,4,[9][10][11][12] varying the size of the bony ostium, 4,[12][13][14] lacrimal sac incision, 15 to stenting. 16,17 Nevertheless, ostial closure or obstruction still occurs, mostly due to excessive scars/synechia or granulation formation at the ostium. 3,5,6,8,9,[18][19][20] Some authors advocate the use of mitomycin C (MMC) intraoperatively to reduce fibrosis formation, [21][22][23][24][25][26] although granulation tissue has been reported to form around the ostia following MMC application during EES-DCR.…”