Endoscopic Techniques in the Diagnosis of Upper Gastrointestinal Tract Malignancies

Malhotra, Vineeta; Puri, Rashmi; Chinna, Rajoo Singh; Chawla, L. S.; Sabharwal, B D

doi:10.1159/000334003

Cited by 8 publications

(14 citation statements)

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“…An early detection of esophageal cancers gives five year survival rate of 83.5% and that of gastric cancer gives more than 90% five year survival rate [4]. Various techniques for the collection of cytological samples have been described [5]. Endoscopic direct vision brush cytology is one among them.…”

Section: Introductionmentioning

confidence: 99%

Cyto Histological Correlation of Brush Cytology with Biopsy in Upper GI Lesions

Devi¹,

Toopalli²,

Kumar³

et al. 2016

SJAMS

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Neoplasms of upper gastrointestinal tract specially malignancy is one of the leading causes of death worldwide. Endoscopy has greatly facilitated the detection and diagnosis of gastrointestinal lesions. Early cancer is highly curable. Unfortunately most early cancers are asymptomatic. Brush cytology and biopsy are complimentary procedures for the detection of upper gastrointestinal neoplasms. 100 cases of non-neoplastic and neoplastic lesions were studied over a period of one year from January 2015 to December 2015 at the Department of Pathology, Gandhi Hospital/Medical College, Hyderabad, Telangana, India. Patients between 21 to 75 years of age presenting to the department of Gastroenterology with complaints of dysphagia, retrosternal pain, vomiting and loss of weight were included in the study. Endoscopy was done using flexible video endoscopy on patients with ulcer or polypoid and ulcerative growths in the upper GIT. Exfoliated cells from the lesion were collected by means of a brush introduced through the endosope. Smears were made by directly smearing the brush on to a slide and fixed with a spray fixative containing 95% ethyl alcohol. Slides were stained by Hematoxylin & Eosin and Papanicoulou stains. After brushing, multiple biopsies were taken from the representative area of the lesions. Cytohistological correlation was done. Brush cytology is a useful, inexpensive procedure that gives rapid diagnosis in cases of endoscopically visible suspicious lesions of upper GIT. It is an accurate diagnostic adjunct to biopsy in the detection of cancers at an early stage.

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Section: Introductionmentioning

confidence: 99%

Cyto Histological Correlation of Brush Cytology with Biopsy in Upper GI Lesions

Devi¹,

Toopalli²,

Kumar³

et al. 2016

SJAMS

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“…The histological sample obtained by endoscopy generally has a limited size; it is used to confirm malignancy but can also be used for molecular purposes and genetic profiling analyses if residual material is available [17]. With regard to cytology, various techniques for the collection of samples that aid diagnosis have been described [18]. Endoscopic brush cytology is one of these.…”

Section: Introductionmentioning

confidence: 99%

Impact of Brush Cytology Analysis for the Diagnosis of Esophageal Squamous Cell Carcinoma: The Quality of Liquid-Based Preparation of Cytological Slides

et al. 2019

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Objectives: The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. Methods: Cytological and biopsy specimens were prospectively taken during esophagogastroduodenoscopy of 123 individuals in 2013 and 2014. Cytology samples were maintained in preservative fluid until processing and biopsies were formalin-fixed and paraffin-embedded. Results: Based on endoscopic biopsy results, 70 cases were positive for ESCC whilst 53 were negative for cancer. In addition, brush cytology showed high sensitivity and specificity (98.57 and 96.23%, respectively) in detecting the disease, and high accuracy (97.5%) comparable to that provided by histopathology which is the accepted gold standard. Conclusion: Brush cytology specimens preserved in liquid medium may be a good alternative for ESCC diagnosis.

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“…The majority of the studies on BC have stressed its role in the diagnosis of malignant lesions, whereas only a few have dealt with non‐neoplastic lesions, most of them being cases of Helicobacter pylori (H. pylori) gastritis . BC is said to be particularly useful in stenosing lesions, the lesions with a bleeding tendency, flat lesions, or when there is a need for selective sampling from a larger area …”

Section: Introductionmentioning

confidence: 99%