Endoscopic Subureteral Collagen Injection

Abstract

In 3 of the 10 children treated with subureteral collagen injection for vesicoureteral reflux serum antibodies to bovine collagen developed. The volume of collagen injected was small, suggesting that volume is not a major determinant of immunogenicity. In 1 patient with seroconversion a local reaction may have been immunogenic. No patient had systemic symptoms of autoimmune disease and there was no seroconversion to antibodies cross-reacting with human collagen.

Is Bone–Wax^® an Injectable Urologic Material?

“…Biodegradable glutaraldehyde cross–linked bovine collagen is another injectable bulking agent [8]. Despite its initial success, collagen has some drawbacks in the long–term, its major flaw being its inability to conserve volume with time [3, 4, 18, 19]. Use of silicone microimplants has been limited due to reports of its migration to the lung, kidneys, brain and lymph nodes in experimental animals [20, 21].…”