Endoscopic submucosal dissection for early gastric cancer with undifferentiated histology: could we extend the criteria beyond?

Abstract

ESD may be a feasible treatment for selected patients with undifferentiated EGC; this should be validated by development of new criteria for ESD for treatment of EGC.

Endoscopic submucosal dissection for early gastric cancer with undifferentiated-type histology: A meta-analysis

“…Among the 14 studies [23][24][25][26][27][28][29][30][31][32][33][34][35][36] , we identified a total of 972 patients with EGC with undifferentiated-type histology. The clinical characteristics of the enrolled studies are shown in Tables 1-2 and Table 3.…”

“…All of the studies were conducted in Asia (10 studies in South Korea and 4 studies in Japan). Two studies were conducted in a multicenter setting [28,33] , whereas the remaining studies were conducted in a single center setting. Twelve English and 2 Korean studies were selected.…”

“…As for complete resection, the onestudy-removed meta-analysis also showed consistent results. For the analysis of curative resection, the one-study-removed meta-analysis highlighted 2 influential studies [28,33] . These studies reported relatively lower curative resection rates; however, the methodological quality of these studies was not low (Table 4).…”

“…Moreover, these 2 studies were performed in a multicenter setting. In the evaluation of recurrence, the one-study-removed analysis identified 3 influential studies [27,33,35] . Two studies [27,35] reported relatively higher recurrence rates, and 1 study [33] reported a relatively lower recurrence rate ( Table 1).…”

“…In the evaluation of recurrence, the one-study-removed analysis identified 3 influential studies [27,33,35] . Two studies [27,35] reported relatively higher recurrence rates, and 1 study [33] reported a relatively lower recurrence rate ( Table 1). The followup duration was relatively short in the Goh et al [27] ' s study (mean 19.39 ± 11.2 mo), and this study had the lowest methodological quality among the included studies (Tables 1 and 4).…”