Endoscopic submucosal dissection for early esophageal cancer in elderly patients with relative indications for endoscopic treatment

Zhang, Qi; Chen, Tao; Li, Bing; Zhong, Ren; Yao, Ling; Shi, Qiang; Cai, Shi‐Lun; Zhong, Yun‐Shi; Zhou, Ping‐Hong

doi:10.1055/a-0577-2560

Cited by 34 publications

(37 citation statements)

References 31 publications

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“…For this reason, we concluded that additional treatment is necessary for cases with lymphovascular involvement and/or positive margin in the histopathology specimen to decrease risk of recurrence and improve survival. That has already been described previously by other authors for curability criteria [9,15]. In our cases, the first line for additional therapy was surgery (3FLD), and chemotherapy for patients who were not eligible for surgical treatment, to avoid recurrence and complications as described in past studies of post-recurrence cases [16].…”

Section: Discussionsupporting

confidence: 70%

Untitled

2019

Endosc Int Open

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Section: Discussionsupporting

confidence: 70%

Untitled

2019

Endosc Int Open

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“…Pre-operative EUS and CT were routinely performed. The study excluded 10 cases of ESD with additional treatment [ 30 ]. The rate of complete resection was 99.4%.…”

Section: Long-term Outcomes Of Esd For Superficial Esophageal Squamentioning

confidence: 99%

Long-Term Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Carcinoma

Nishizawa

Suzuki

2020

Cancers

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In this review, we summarize up-to-date reports with 5-year survival after endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell carcinoma. In ESD for the depth of the epithelium (m1) or lamina propria (m2), the 5-year cause-specific survival and 5-year overall survival rates were reported to be 98–100%, and 85–95%, respectively. In cases with submucosal invasion or vascular involvement, additional prophylactic treatment such as chemoradiotherapy or surgery was recommended, and the 5-year cause-specific survival and 5-year overall survival rates were reported to be 85–100%, and 56–84%, respectively. Additional treatment might be too invasive for the elderly or patients with severe comorbidities. The risk of additional therapy should be balanced against the risk of lymph node metastasis, considering the life expectancy of such patients.

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“…In our study, we investigated additional treatment options and long‐term outcomes of patients who were confirmed to have SMI or LVI after endoscopic resection. We speculated that elderly patients tend to refuse additional treatment such as surgery or CCRT because of their physical status and the psychological burden of additional treatment . However, in this study, the proportion of patients who did not undergo additional treatment was similar between the two groups.…”

Section: Discussionmentioning

confidence: 61%

Endoscopic submucosal dissection for superficial esophageal neoplasms in elderly patients: A single‐center, large‐scale, retrospective study

Noh

Gong

Kim

et al. 2020

Geriatrics Gerontology Int

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Aim: The number of elderly patients with superficial esophageal neoplasms has steadily increased, but few studies have focused on the clinical outcomes of esophageal endoscopic submucosal dissection in these patients. Therefore, the aim of our study was to investigate the feasibility and safety of endoscopic submucosal dissection among elderly patients with superficial esophageal neoplasms.Methods: Patients who underwent endoscopic submucosal dissection for superficial esophageal neoplasms between December 2005 and December 2017 were eligible. The patients were divided into two groups according to age: Not-old (<75 years, n = 369) and Old (≥75 years, n = 44). Clinical features and treatment outcomes were retrospectively investigated by reviewing medical records.Results: In total, 413 patients with 459 lesions were enrolled in to this study. Comorbidities, except for a previous history of malignancy, were not significantly different between the two groups. Procedure-related characteristics and the rate of adverse events were similar in the two groups. During a median follow-up period of 33.4 months, the overall survival rate was lower in the Old group (P = 0.046), and the cumulative recurrence rate did not differ significantly between the two groups (P = 0.334).Conclusion: Based on these favorable outcomes, endoscopic submucosal dissection is as feasible and effective for the treatment of superficial esophageal neoplasms among elderly patients as it is among non-elderly patients. Geriatr Gerontol Int 2020; 20: 430-435.

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Endoscopic submucosal dissection for early esophageal cancer in elderly patients with relative indications for endoscopic treatment

Abstract: Based on this study, regular follow-up without additional treatment may be considered as another choice for elderly patients with early esophageal SCC and relative indications after ESD.

Cited by 34 publications

References 31 publications

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Long-Term Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Carcinoma

Endoscopic submucosal dissection for superficial esophageal neoplasms in elderly patients: A single‐center, large‐scale, retrospective study

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