Long-Term Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Carcinoma

Nishizawa, Toshihiro; Suzuki, Hideji

doi:10.3390/cancers12102849

Cited by 22 publications

(47 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, through the combined therapy of ER and RFA, the background esophageal mucosa was significantly improved postoperatively (70.2%), especially for patients with preoperative background esophageal mucosa assessed as Grade D (80.2%). Besides, compared with that of previous studies (6,7,15,32), the additional RFA for multiple LVLs on the basis of ER of early ESCNs did not increase the incidence of postoperative complications. Thus, this combination treatments for patients with early ESCNs and synchronous multiple LVLs not only can give full play to the advantages of complete resection of the primary lesions and pathological evaluation postoperatively but also can leverage the advantages of RFA in the treatment of dense, scattered, and irregular multiple LVLs.…”

Section: Discussionmentioning

confidence: 46%

“…Keisuke et al (5) found that most of the LVLs with size less than 5 mm were diagnosed as non-neoplastic lesion (42.1%) or low-grade intraepithelial neoplasia (LGIN) (54.0%) according to pathological results of the biopsy or resected specimens. Patients with dysplasia and superficial ESCC (intramucosal or submucosal carcinoma) exhibit an overall 5year survival rate of >90% (6).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions

et al. 2021

View full text Add to dashboard Cite

BackgroundLocal recurrence of esophageal squamous cell neoplasia (ESCN) and metachronous ESCN was associated with severe background esophageal multiple Lugol-voiding lesions (LVLs) even though the primary early ESCNs were treated with endoscopic resection (ER). The aim of this study is to explore the feasibility and effectiveness of combination treatments of ER and radiofrequency ablation (RFA) in patients with early ESCNs with synchronous multiple LVLs.MethodsA total of 329 patients with early ESCNs and synchronous multiple LVLs received ER combined with RFA from September 2010 to September 2020. Clinical and pathological features and treatment outcomes were retrospectively reviewed using medical records. Factors associated with background esophageal multiple LVLs before combined treatment were analyzed.ResultsThe proportion of complete response (CR) was 96.7% after primary RFA, while 90.3% patients achieved CR for the last endoscopic examinations regardless if inside or outside the treatment area (TA). Degeneration of background esophageal multiple LVLs occurred in 70.2% of patients. The grade of background esophageal multiple LVLs before combined treatment was closely related to gender, smoking, and drinking. The incidence of metachronous ESCNs outside the TA of ER and local recurrence in the TA of ER was 3.9% and 1.2%, respectively.ConclusionsProphylactic RFA treatment of multiple LVLs together with ER treatment of the primary ESCNs may be effective in reducing the incidence of metachronous ESCNs and local recurrence through improving the background esophageal mucosa.

show abstract

Section: Discussionmentioning

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions

et al. 2021

View full text Add to dashboard Cite

show abstract

“…As a result, 5-year survival rates are low (5–15%) but significantly improve when diagnosis is made at early stages [ 5 ]. Notably, a 95% 5-year survival rate has been reported given early diagnosis [ 6 ]. Despite several ongoing efforts for early detection of ESCC in endemic areas [ 7 ], a minimally invasive and feasible approach has yet to be developed.…”

Section: Introductionmentioning

confidence: 99%

TP53 Targeted Deep Sequencing of Cell-Free DNA in Esophageal Squamous Cell Carcinoma Using Low-Quality Serum: Concordance with Tumor Mutation

Nasrollahzadeh

Roshandel

Delhomme

et al. 2021

IJMS

View full text Add to dashboard Cite

Circulating cell-free DNA (cfDNA) is emerging as a potential tumor biomarker. CfDNA-based biomarkers may be applicable in tumors without an available non-invasive screening method among at-risk populations. Esophageal squamous cell carcinoma (ESCC) and residents of the Asian cancer belt are examples of those malignancies and populations. Previous epidemiological studies using cfDNA have pointed to the need for high volumes of good quality plasma (i.e., >1 mL plasma with 0 or 1 cycles of freeze-thaw) rather than archival serum, which is often the main available source of cfDNA in retrospective studies. Here, we have investigated the concordance of TP53 mutations in tumor tissue and cfDNA extracted from archival serum left-over from 42 cases and 39 matched controls (age, gender, residence) in a high-risk area of Northern Iran (Golestan). Deep sequencing of TP53 coding regions was complemented with a specialized variant caller (Needlestack). Overall, 23% to 31% of mutations were concordantly detected in tumor and serum cfDNA (based on two false discovery rate thresholds). Concordance was positively correlated with high cfDNA concentration, smoking history (p-value = 0.02) and mutations with a high potential of neoantigen formation (OR; 95%CI = 1.9 (1.11–3.29)), suggesting that tumor DNA release in the bloodstream might reflect the effects of immune and inflammatory context on tumor cell turnover. We identified TP53 mutations in five controls, one of whom was subsequently diagnosed with ESCC. Overall, the results showed that cfDNA mutations can be reliably identified by deep sequencing of archival serum, with a rate of success comparable to plasma. Nonetheless, 70% non-identifiable mutations among cancer patients and 12% mutation detection in controls are the main challenges in applying cfDNA to detect tumor-related variants when blindly targeting whole coding regions of the TP53 gene in ESCC.

show abstract

“…[11][12][13] The 5-year cause-specific survival and 5-year overall survival rates were reported to be 98-100% and 85-95% in endoscopic submucosal dissection (ESD) of the depth of the epithelium (EP) or lamina propria mucosae (LPM), respectively. 14 White-light endoscopy (WLE) is the standard modality for detecting esophageal neoplastic lesions. However, the endoscopic features of early esophageal neoplastic lesions under WLE are subtle and isochromatic.…”

Section: Introductionmentioning

confidence: 99%

Current Status of Image-Enhanced Endoscopy for Early Identification of Esophageal Neoplasms

Kim

Hong

2021

Clin Endosc

View full text Add to dashboard Cite

The early detection of esophageal neoplasms, including esophageal dysplasia and early esophageal cancer, is highly important for the accurate treatment of the disease. However, esophageal dysplasia and early esophageal cancer are usually subtle and can be easily missed. In addition to the early detection, proper pretreatment evaluation of the depth of invasion of esophageal cancer is very important for curative treatment. The progression of non-invasive diagnosis via image-enhanced endoscopy techniques has been shown to aid the early detection and estimate the depth of invasion of early esophageal cancer and, as a result, may provide additional opportunities for curative treatment. Here, we review the advancement of image-enhanced endoscopy-related technologies and their role in the early identification of esophageal neoplasms.

show abstract

Long-Term Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Carcinoma

Cited by 22 publications

References 45 publications

Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions

Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions

TP53 Targeted Deep Sequencing of Cell-Free DNA in Esophageal Squamous Cell Carcinoma Using Low-Quality Serum: Concordance with Tumor Mutation

Current Status of Image-Enhanced Endoscopy for Early Identification of Esophageal Neoplasms

Contact Info

Product

Resources

About