Endoscopic features associated with development of metachronous gastric cancer in patients who underwent endoscopic resection followed by <scp><i>Helicobacter pylori</i></scp> eradication

Moribata, Kosaku; Kato, Jun; Iguchi, Mikitaka; Nakachi, Kenichiro; Maeda, Yoshimasa; Shingaki, Naoki; Niwa, Toshimitsu; Deguchi, Hisanobu; Inoue, Izumi; Maekita, Takao; Tamai, Hideyuki; Ichinose, Masakazu

doi:10.1111/den.12581

Cited by 38 publications

(51 citation statements)

References 27 publications

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“…In our study, about 55% of patients in which erosion was detected were H. pylori negative (Table 2), indicating that erosion is not an accurate indicator of the presence or absence of H. pylori infection. Patch redness has also been suggested as an indicator of H. pylori eradication [24]. In this study we observed patchy redness in only 4 patients, and although all 4 patients were H. pylori negative, we feel that this number of cases is insufficient to draw a reliable conclusion.…”

Section: Discussioncontrasting

confidence: 57%

Association of Endoscopic Features of Gastric Mucosa withHelicobacter pyloriInfection in Chinese Patients

Mao

Wang

Yin

et al. 2016

Gastroenterology Research and Practice

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The aim of this study is to identify and consolidate reliable endoscopic features associated with H. pylori infection in gastric mucosa, which is one of the major causes of gastric cancer. A total of 256 Chinese patients with symptomatic stomach disturbances were enrolled. Pathological examination was conducted using a light microscope and biopsy specimens stained with hematoxylin-eosin. Endoscopic examination was performed using a high resolution video endoscope. The association between endoscopic features and pathological H. pylori diagnosis was compared, and endoscopic features significantly associated with H. pylori infection were identified. A total of 14 endoscopic features were observed. Six of the 14 endoscopic features, including mucus on the gastric mucosa, diffuse redness, spotty redness of fundic mucosa, enlarged fold, mucosal edema, and RAC (type D and type I), were highly associated with H. pylori infection and were significantly sensitive and specific predictors for H. pylori diagnosis. The type R RAC was not significantly associated with H. pylori diagnosis. Our results indicate that conventional endoscopy features can be used to diagnose H. pylori in Chinese patients and can help determine the risk factor for gastric cancer.

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Section: Discussioncontrasting

confidence: 57%

Association of Endoscopic Features of Gastric Mucosa withHelicobacter pyloriInfection in Chinese Patients

Mao

Wang

Yin

et al. 2016

Gastroenterology Research and Practice

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“…LCI enables the detection of not only bluish-whitish patchy areas in NBI as LCS but also GIM as mottled patchy erythema and map-like redness, which typically appear after H. pylori eradication in patients with severe atrophy [25,26]. Actually, if WFE and mottled patchy area in the antrum were defined as GIM in WLI, the sensitivity of detection of GIM in WLI for our subjects was 29.3%.…”

Section: Discussionmentioning

confidence: 91%

Lavender Color in Linked Color Imaging Enables Noninvasive Detection of Gastric Intestinal Metaplasia

et al. 2018

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Background and Aims: Recently, there have been some reports that image-enhanced endoscopy may improve detection of gastric intestinal metaplasia (GIM). Our aim was to determine the usefulness of linked color imaging (LCI) for detection of GIM. Methods: In prospectively recruited patients, the whole antrum was observed by white light imaging (WLI) followed by LCI. When a whitish flat elevation (WFE) in WLI and a lavender color sign (LCS) in LCI were detected, target biopsies were performed after LCI. Random biopsies were performed in patients who had neither WFE nor LCS. The primary endpoint was the diagnostic accuracy of GIM per patient in WLI and LCI and the secondary endpoints were that of GIM per biopsy and interobserver agreement. Results: Data from 128 patients were analyzed and 58 patients (45.3%) had histological GIM in the antrum. The per-patient yields of WLI and LCI to detect GIM were 19.0% (11/58) and 91.4% (53/58) respectively. Diagnostic accuracies of target biopsies for GIM were 23.7% in WLI and 84.2% in LCI. Kappa values among 3 doctors were 0.60 for WFE and 0.78 for LCS respectively. Conclusion: LCI could be a new diagnostic tool for detecting GIM during routine endoscopy.

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“…Moribata et al . revealed that emergence of map‐like redness was identified as the only independent predictors for the development of metachronous EGC after successful H. pylori eradication in patients who underwent endoscopic submucosal dissection for EGC.…”

Section: Endoscopic Findings With Regard To Risk Of Gastric Cancermentioning

confidence: 99%

“…However, the total score of this grading system after H. pylori eradication therapy may not reflect the accurate risk of gastric cancer because of the disappearance of diffuse redness, nodularity, and enlarged folds. Furthermore, map‐like redness and the absence of RAC were identified as independent risks of gastric cancer after H. pylori eradication . Therefore, a new grading system, which includes the findings of mucosal atrophy, intestinal metaplasia, map‐like redness and RAC, will be required to determine a risk of gastric cancer in patients with past H. pylori infection.…”

Section: Evaluation Of Gastric Cancer Risk According To Kyoto Classifmentioning

confidence: 99%

Can image‐enhanced endoscopy improve the diagnosis of Kyoto classification of gastritis in the clinical setting?

Dohi

Majima

Naito

et al. 2019

Digestive Endoscopy

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Endoscopic diagnosis of Helicobacter pylori (H. pylori) infection, the most common cause of gastric cancer, is very important to clarify high-risk patients of gastric cancer for reducing morbidity and mortality of gastric cancer. Recently, the Kyoto classification of gastritis was developed based on the endoscopic characteristics of H. pylori infection-associated gastritis for clarifying H. pylori infection status and evaluating risk factors of gastric cancer. Recently, magnifying endoscopy with narrow-band imaging (NBI) has reported benefits of the accuracy and reproducibility of endoscopic diagnosis for H. pylori-related premalignant lesions. In addition to NBI, various types of image-enhanced endoscopies (IEEs) are available including autofluorescence imaging, blue laser imaging, and linked color imaging. This review focuses on understanding the clinical applications and the corresponding evidences shown to improve the diagnosis of gastritis based on Kyoto classification using currently available advanced technologies of IEEs.

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Endoscopic features associated with development of metachronous gastric cancer in patients who underwent endoscopic resection followed by Helicobacter pylori eradication

Abstract: Absence of IM before ESD and emergence of map-like redness after HP eradication were useful endoscopic findings in the negative and positive prediction of metachronous gastric cancer developing after ESD.

Cited by 38 publications

References 27 publications

Association of Endoscopic Features of Gastric Mucosa withHelicobacter pyloriInfection in Chinese Patients

Association of Endoscopic Features of Gastric Mucosa withHelicobacter pyloriInfection in Chinese Patients

Lavender Color in Linked Color Imaging Enables Noninvasive Detection of Gastric Intestinal Metaplasia

Can image‐enhanced endoscopy improve the diagnosis of Kyoto classification of gastritis in the clinical setting?

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