Endoscopic Diagnostic System Using Autofluorescence

Takehana, Sakae; Kaneko, Mamoru; Mizuno, Hitoshi

doi:10.1155/dte.5.59

Cited by 39 publications

(29 citation statements)

References 14 publications

(18 reference statements)

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“…The captured signals are respectively transformed into red or blue colors, and are displayed on the monitor in real-time as a color image [9,11]. While the normal colorectal mucosa appears green, a lesion that attenuates the excitation light or the endogenous fluorophores, including thickened mucosa due to neoplasm and inflammation, will appear in magenta (Fig.…”

Section: Autofluorescence Imaging Technologymentioning

confidence: 99%

“…In this aspect, the diagnostic ability of NBI is closely associated with the ability to recognize vascular patterns, thus the diagnostic accuracy of NBI appears to be dependent on the experience of individual endoscopists. AFI is another novel IEE technology that can capture fluorescence (500-630 nm) emitted from the fluorophores in human tissue [9,10]. AFI can assess lesions without any morphological assessments based on the fluorescence intensity.…”

Section: Introductionmentioning

confidence: 99%

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The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

Moriichi

Fujiya

Okumura

2016

Clin J Gastroenterol

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Image-enhanced endoscopy (IEE) has been developed and is applied in the clinical setting throughout the world. Most reports regarding IEE have evaluated the efficacy of narrow-band imaging (NBI) in the diagnosis of gastrointestinal disorders. Although autofluorescence imaging (AFI) is a form of IEE, its usefulness remains unclear. The present review focused on the efficacy of AFI in the diagnosis of colorectal disease, particularly neoplasia and ulcerative colitis (UC). AFI-based diagnoses are made via the subjective judgment of the color on the monitor. The efficacy of AFI in detection and differentiation in patients with colorectal neoplastic lesions remains controversial, which may be dependent on the study design and the diagnostic procedures. Although the number of the reports related to UC is very small, most suggest that AFI is effective in UC patients. AFI is distinct from other modalities in that it can quantitatively assess the lesion based on the fluorescence intensity without any morphological assessments. AFI could be useful for patients with colorectal disease.Keywords Autofluorescence imaging (AFI) Á Colorectal neoplasia Á Ulcerative colitis (UC) Á Colitis-associated cancer Á Narrow-band imaging (NBI) Á Image-enhanced endoscopy (IEE) Á White light endoscopy (WLE)

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Section: Autofluorescence Imaging Technologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

Moriichi

Fujiya

Okumura

2016

Clin J Gastroenterol

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“…The signal density of either red or green in the traced area was measured and converted to a reverse gamma value which corresponded to the strength of the output from each CCD signal. The ratio of the reverse gamma value of green (fluorescence) divided by that of red (reflex) was defined as the fluorescence index (F index; FI=green (fluorescence)/red (reflex)) [18][19][20][21]. This quantification was performed 1 month after the endoscopic examination by endoscopists who were not aware of the endoscopic or histological information of the patient.…”

Section: Endoscopymentioning

confidence: 99%

Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis

Moriichi

Fujiya

Ijiri

et al. 2015

Int J Colorectal Dis

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“…Autofluorescence (AF) endoscopy is a novel imaging technology in which endogenous fluorophores in the tissues are stimulated when the mucosa is illuminated by a shortwavelength light and a fluorescent light of a longer wavelength (6)(7)(8)(9)(10). Recently, several groups have reported on the usefulness of AF endoscopy in the differential diagnosis of colorectal mucosal lesions, suggesting that AF endoscopy is useful for distinguishing adenomas from hyperplastic polyps (11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of colorectal mucosal lesions by autofluorescence endoscopy: Discrimination of carcinomas from other lesions

Arita

Mitsuyama

Kawano³

et al. 2011

Oncol Rep

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Abstract.A newly developed autofluorescence (AF) imaging technique was applied during colonoscopy in a clinical setting. This pilot study was conducted to evaluate the clinical feasibility of applying AF endoscopy for distinguishing colorectal lesions. A total of 54 colorectal mucosal lesions obtained from 43 patients who underwent both white-light and AF endoscopy and were treated by endoscopy or surgery were assessed. Of the lesions, 11 were hyperplastic polyps, 30 were adenomas and 13 were carcinomas. To quantify the AF intensity, a color-contrast index (CCI) was determined and evaluated in relation to the histology, size and shape of each lesion. CCI was significantly associated with the histology and size of the lesions, but not their shape. CCI increased as the malignant potential increased (in the order of hyperplastic polyps → adenomas → carcinomas), irrespective of the lesion size (r=0.797, p<0.0001 for size >8 mm; r=0.622, p=0.0045 for size >8 mm but >15 mm; r=0.644, p=0.0071 for size >15 mm). In each size group, CCI tended to be higher for carcinomas than for adenomas, and also higher for adenomas than for hyperplastic polyps. CCI allowed discrimination of adenomas/carcinomas from hyperplastic polyps with 95.3% sensitivity and 63.6% specificity (cut-off value, 14.5), and of colorectal carcinomas from adenomas with 84.6% sensitivity and 80.0% specificity (cut-off value, 28.0). These results suggest that the quantitative analysis of AF intensity using CCI is helpful to discriminate among different types of colorectal mucosal lesions, including carcinomas.

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Endoscopic Diagnostic System Using Autofluorescence

Cited by 39 publications

References 14 publications

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis

Quantitative analysis of colorectal mucosal lesions by autofluorescence endoscopy: Discrimination of carcinomas from other lesions

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