Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis

Moriichi, Kentaro; Fujiya, Mikihiro; Ijiri, Masami; Tanaka, Kazuyuki; Sakatani, Aki; Fujibayashi, Shugo; Ando, Koji; Nomura, Yoshiki; Ueno, Nobuhiro; Gotoh, Takuma; Sasajima, Junpei; Inaba, Yohei; Itô, Takahiro; Tanabe, Hiroki; Saitoh, Yusuke; Kohgo, Yutaka

doi:10.1007/s00384-015-2332-5

Cited by 14 publications

(18 citation statements)

References 20 publications

(31 reference statements)

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“…We also reported that the quantification of AFI was useful for assessing the severity of UC and that the intensity of AFI was inversely related to the histological severity. Furthermore, the quantified AFI showed a high level of accuracy and excellent inter-observer consistency [54].…”

Section: The Assessment Of Inflammation In Uc Patientsmentioning

confidence: 86%

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

Moriichi

Fujiya

Okumura

2016

Clin J Gastroenterol

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Image-enhanced endoscopy (IEE) has been developed and is applied in the clinical setting throughout the world. Most reports regarding IEE have evaluated the efficacy of narrow-band imaging (NBI) in the diagnosis of gastrointestinal disorders. Although autofluorescence imaging (AFI) is a form of IEE, its usefulness remains unclear. The present review focused on the efficacy of AFI in the diagnosis of colorectal disease, particularly neoplasia and ulcerative colitis (UC). AFI-based diagnoses are made via the subjective judgment of the color on the monitor. The efficacy of AFI in detection and differentiation in patients with colorectal neoplastic lesions remains controversial, which may be dependent on the study design and the diagnostic procedures. Although the number of the reports related to UC is very small, most suggest that AFI is effective in UC patients. AFI is distinct from other modalities in that it can quantitatively assess the lesion based on the fluorescence intensity without any morphological assessments. AFI could be useful for patients with colorectal disease.Keywords Autofluorescence imaging (AFI) Á Colorectal neoplasia Á Ulcerative colitis (UC) Á Colitis-associated cancer Á Narrow-band imaging (NBI) Á Image-enhanced endoscopy (IEE) Á White light endoscopy (WLE)

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Section: The Assessment Of Inflammation In Uc Patientsmentioning

confidence: 86%

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

Moriichi

Fujiya

Okumura

2016

Clin J Gastroenterol

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“…By adding an RGB (red, green, and blue) additive color model in silico, a strong inverse correlation between the green color component of AFI images and the severity of the mucosal inflammation was found [10]. In a similar prospective study by Moriichi et al, 135 WLE and AFI images from the same lesion in 43 patients with UC were evaluated by eleven endoscopists [11]. The AFI intensity significantly inversely correlated with the histologically graded severity of inflammation, and AFI was superior to standard white-light video endoscopy (SVE) regarding detection of inflammation (85% vs. 79%).…”

Section: Afi In Intestinal Inflammationmentioning

confidence: 99%

Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues

et al. 2020

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The autofluorescence (AF) characteristics of endogenous fluorophores allow the label-free assessment and visualization of cells and tissues of the human body. While AF imaging (AFI) is well-established in ophthalmology, its clinical applications are steadily expanding to other disciplines. This review summarizes clinical advances of AF techniques published during the past decade. A systematic search of the MEDLINE database and Cochrane Library databases was performed to identify clinical AF studies in extra-ophthalmic tissues. In total, 1097 articles were identified, of which 113 from internal medicine, surgery, oral medicine, and dermatology were reviewed. While comparable technological standards exist in diabetology and cardiology, in all other disciplines, comparability between studies is limited due to the number of differing AF techniques and non-standardized imaging and data analysis. Clear evidence was found for skin AF as a surrogate for blood glucose homeostasis or cardiovascular risk grading. In thyroid surgery, foremost, less experienced surgeons may benefit from the AF-guided intraoperative separation of parathyroid from thyroid tissue. There is a growing interest in AF techniques in clinical disciplines, and promising advances have been made during the past decade. However, further research and development are mandatory to overcome the existing limitations and to maximize the clinical benefits.

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“…Both fluorescence and autofluorescence endoscopy are emerging imaging techniques that rely on visualization of fluorescence light (wavelength: 500–630 nm) emitted by either administered or endogenous fluorophores. In a prospective study of 43 patients with UC, the yield of autofluorescence imaging was superior to WLE in inflammation detection (85% versus 79%) [ 52 ]. Fluorescence endoscopy with 5-aminolevulinic acid (5-ALA) in comparison with WLE showed no significant difference in the dysplasia detection rate in IBD [ 53 ].…”

Section: Advanced Endoscopic Imaging Techniquesmentioning

confidence: 99%

Modern Endoscopic Imaging in Diagnosis and Surveillance of Inflammatory Bowel Disease Patients

Hundorfean

Pereira

Karstensen

et al. 2018

Gastroenterology Research and Practice

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Endoscopy remains the most important diagnostic and monitoring modality in the management of inflammatory bowel disease. Advances in imaging have progressively added new tools into the armamentarium of endoscopists with the goal of more accurate, sensitive, and accessible visual diagnoses for the benefit of patients with gastrointestinal diseases. Here, we review the relevant literature regarding commonly used endoscopic techniques (dye-based and digital chromoendoscopy, high-definition endoscopy, capsule endoscopy, and endosonography), as well as advanced and experimental technologies (full-spectrum endoscopy, endocytoscopy, autofluorescence, laser endoscopy, and endomicroscopy, including molecular imaging), applicable to inflammatory bowel diseases and emerging for implementation into everyday practice. Additionally, we discuss future directions and techniques as candidates for a superior inflammation imaging in the diagnosis and prediction of therapeutic response.

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Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis

Abstract: The quantified AFI is considered to be an accurate and objective indicator that can be used to assess the activity of ulcerative colitis, particularly for less-experienced endoscopists.

Cited by 14 publications

References 20 publications

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues

Modern Endoscopic Imaging in Diagnosis and Surveillance of Inflammatory Bowel Disease Patients

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